Sensitive and reliable identification of fentanyl citrate in urine and serum using chloride ion-treated paper-based SERS substrate

Han, Siqingaowa; Zhang, Chen; Lin, Shuang; Sha, Xuanyu; Hasi, Wuliji

doi:10.1016/j.saa.2021.119463

Cited by 21 publications

(12 citation statements)

References 43 publications

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“…A SERS-chemometric method was established for the detection of urinary adenosine [267]. Some applications in biological [268][269][270][271][272] in 2021 were shown in Table 2.…”

Section: Biological Applicationsmentioning

confidence: 99%

Recent Advances and Applications in Paper-Based Devices for Point-of-Care Testing

Hou

Guo

et al. 2022

J. Anal. Test.

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Point-of-care testing (POCT), as a portable and user-friendly technology, can obtain accurate test results immediately at the sampling point. Nowadays, microfluidic paper-based analysis devices (μPads) have attracted the eye of the public and accelerated the development of POCT. A variety of detection methods are combined with μPads to realize precise, rapid and sensitive POCT. This article mainly introduced the development of electrochemistry and optical detection methods on μPads for POCT and their applications on disease analysis, environmental monitoring and food control in the past 5 years. Finally, the challenges and future development prospects of μPads for POCT were discussed.

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“…A SERS-chemometric method was established for the detection of urinary adenosine [267]. Some applications in biological [268][269][270][271][272] in 2021 were shown in Table 2.…”

Section: Biological Applicationsmentioning

confidence: 99%

Recent Advances and Applications in Paper-Based Devices for Point-of-Care Testing

Hou

Guo

et al. 2022

J. Anal. Test.

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“…Han et al presented a paper-based SERS substrate decorated with uniform gold nanospheres for detecting fentanyl citrate in urine and serum [ 77 ]. The substrate was prepared by a liquid/liquid self-assembly technique, and chloride ions were applied to clean and modify the substrate surface.…”

Section: Applications Of Sers In Drug Detectionmentioning

confidence: 99%

“…( B ) Illustration of a portable kit for rapid SERS detection of drugs in real human urine [ 74 ]. ( C ) Steps involved in the fabrication of gold nanoparticle cluster arrays using polystyrene-block-poly(2-vinylpyridine) (PSb-P2VP) templates on a silicon or glass surface [ 77 ].…”

Section: Figurementioning

confidence: 99%

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection

Azimi¹,

Docoslis²

2022

Sensors

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The rapid increase in illicit drug use and its adverse health effects and socio-economic consequences have reached alarming proportions in recent years. Surface-enhanced Raman scattering (SERS) has emerged as a highly sensitive analytical tool for the detection of low dosages of drugs in liquid and solid samples. In the present article, we review the state-of-the-art use of SERS for chemical analysis of illicit drugs in aqueous and complex biological samples, including saliva, urine, and blood. We also include a review of the types of SERS substrates used for this purpose, pointing out recent advancements in substrate fabrication towards quantitative and qualitative detection of illicit drugs. Finally, we conclude by providing our perspective on the field of SERS-based drug detection, including presently faced challenges. Overall, our review provides evidence of the strong potential of SERS to establish itself as both a laboratory and in situ analytical method for fast and sensitive drug detection and identification.

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“…In fact, the investigation of many drugs of abuse has been explored with SERS including amphetamines, MDMA, and amphetamine-like substances (Bell et al, 2000;Sägmüller et al, 2001;Faulds et al, 2002); barbiturates (Farquharson and Lee, 2000); mephedrone (Mabbott et al, 2013); and other types of drugs including cocaine, morphine, hydrocodone, fentanyl, codeine, diazepam, and fentanyl analogs (Farquharson et al, 2011;Rana et al, 2011;Leonard et al, 2017;Haddad et al, 2018;Shende et al, 2019b;Wang et al, 2019, Smith et al, 2021Wang H. et al, 2021;Wang L. et al, 2021;Wilson et al, 2021;Zhang et al, 2021). The use of SERS has also enabled the analysis of these drug analytes in toxicological specimens such as urine, saliva, and blood (Inscore et al, 2011;Andreou et al, 2013;D'Elia et al, 2018;Shende et al, 2019a;Sivashanmugan et al, 2019;Han et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Forensic Identification of Fentanyl and its Analogs by Electrochemical-Surface Enhanced Raman Spectroscopy (EC-SERS) for the Screening of Seized Drugs of Abuse

et al. 2022

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Reliable identification of fentanyl and fentanyl analogs present in seized drug samples is imperative to the safety of first responders and laboratory personnel and informs the future analysis process and handling procedures. The electrochemical-surface enhanced Raman spectroscopy (EC-SERS) method developed in this work allows the in-situ preparation of the SERS substrate providing a rapid, efficient, and accurate approach to detect fentanyl, even at low percent by weight concentrations common in seized drugs. Optimization of the electrochemical potentials suitable for the SERS substrate preparation and adsorption of the analyte was achieved using multi-pulse amperometric detection. This method demonstrated large enhancement of the SERS response. This method was applied to six fentanyl analogs with substitutions to the amide group, representing small changes in the fentanyl core structure. Identification of these analogs through differences in the EC-SERS spectra was evident. Interference studies incorporating analytes frequently encountered with fentanyl including heroin, cocaine, methamphetamine, naltrexone, and naloxone were assessed and found to offer limited to no interference. The limits of detection of the fentanyl compounds were in the low to mid nanograms per milliliter range, with the most sensitive compound detected at 10 ng/ml. Application of the method to simulated drug mixtures was performed to determine fit-for-purpose. In all mixtures with fentanyl as the minor contributor, fentanyl was correctly identified, including mixture samples comprised of 5 and 1% fentanyl. This approach represents the first in-situ EC-SERS analysis of fentanyl and its analogs and provides accurate and efficient screening for fentanyl in seized drug samples.

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Sensitive and reliable identification of fentanyl citrate in urine and serum using chloride ion-treated paper-based SERS substrate

Cited by 21 publications

References 43 publications

Recent Advances and Applications in Paper-Based Devices for Point-of-Care Testing

Recent Advances and Applications in Paper-Based Devices for Point-of-Care Testing

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection

Forensic Identification of Fentanyl and its Analogs by Electrochemical-Surface Enhanced Raman Spectroscopy (EC-SERS) for the Screening of Seized Drugs of Abuse

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