Sensitive Determination of Fluoroquinolone Antibiotics in Milk Samples Using Time‐Resolved Methodology

Rodríguez-Díaz, Rafael Carlos; Aguilar-Caballos, M.P.; Gómez‐Hens, A.

doi:10.1081/al-120034061

Cited by 13 publications

(6 citation statements)

References 18 publications

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“…The Tb(III) ion is of particular interest as a luminescent probe for detection of organic analytes in batch solutions and for fluorescence labelling in clinical chemistry and molecular biology [10][11][12]. Terbium(III) ions can form stable complexes or chelates with various organic ligands and undergo intramolecular energy transfer through the triplet state of the ligand to the emitting level of the lanthanide ion [13].…”

Section: Introductionmentioning

confidence: 99%

“…Terbium(III) ions can form stable complexes or chelates with various organic ligands and undergo intramolecular energy transfer through the triplet state of the ligand to the emitting level of the lanthanide ion [13]. It has been also reported that the fluorescence intensity of Tb(III) is enhanced in the presence of cationic (e.g., cetyltrimethylammonium bromide) [14] or anionic (e.g., sodium dodecyl sulfate and sodium dodecylbenzene sulfonate) [10,15] surfactants. It is therefore of interest to obtain more detailed information on the interaction of this cation with surfactants.…”

Section: Introductionmentioning

confidence: 99%

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Effect of terbium(III) chloride on the micellization properties of sodium decyl- and dodecyl-sulfate solutions

Neves

Valente

Burrows

et al. 2007

Journal of Colloid and Interface Science

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The effect of TbCl 3 on the aggregation processes of the anionic surfactants sodium decyl sulfate (SDeS) and sodium dodecyl sulfate (SDS) has been investigated. Electrical conductivity data, combined with Tb(III) luminescence measurements suggest that the formation of micelles involving TbCl 3 and SDS occurs at concentrations below the critical micelle concentration (cmc) of the pure surfactants; the formation of these mixed aggregates was also monitored by light scattering, which indicates that the addition of TbCl 3 to surfactant concentration at values below the pure surfactant cmc results in a much greater light scattering than that found with pure sodium alkylsulfate surfactant micelles. This phenomenon is dependent upon the alkyl chain length of the surfactant. With Tb(III)/DS − , complexes are formed with a cation/anion binding ratio varying from 3 to 6, which depends upon the initial concentration of Tb(III). This suggests that the majority of the cation hydration water molecules can be exchanged by the anionic surfactant. When the carbon chain length decreases, interactions between surfactant and Tb(III) also decrease, alterations in conductivity and fluorescence data are not so significant and, consequently, no binding ratio can be detected even if existing. The surfactant micellization is dependent on the presence of electrolyte in solution with apparent cmc being lower than the corresponding cmc value of pure SDS.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of terbium(III) chloride on the micellization properties of sodium decyl- and dodecyl-sulfate solutions

Neves

Valente

Burrows

et al. 2007

Journal of Colloid and Interface Science

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“…In addition, some potential interferences from sample matrix, which usually emit at shorter wavelengths, can be avoided. With regard to the determination of quinolone antibiotics, TSL has been proposed for the individual determination ( − ) or for the resolution of binary mixtures of quinolones (), the latter performed by using kinetic methodology. Most of these methods have been applied to the analysis of biological fluids ( 17 , − , their application to food analysis ( 18 , 23 , 24 ) being more limited to date.…”

Section: Introductionmentioning

confidence: 99%

Determination of Fluoroquinolones in Milk Samples by Postcolumn Derivatization Liquid Chromatography with Luminescence Detection

Rodríguez-Díaz

Fernández-Romero

Aguilar-Caballos

et al. 2006

J. Agric. Food Chem.

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A liquid chromatography (LC) method with luminescence detection for the determination of eight quinolone antibiotics is reported. The system encompasses three consecutive steps: (a) chromatographic separation using reverse-phase mode (RP-LC), (b) postcolumn derivatization reaction, and (c) luminescence detection by monitoring fluorescence (FL) and time-resolved (TR) signals. The derivatization step is based on the reaction between quinolones and terbium(III) to form luminescent chelates, which were determined at lambda(ex) 340 and lambda(em) 545 nm (FL mode) or at lambda(ex) 281 and lambda(em) 545 nm (TR mode). Dynamic ranges of the calibration graphs, obtained with standard solutions of analytes and FL and TR modes, respectively, were 190-3500 and 316-2000 ng mL-1 for marbofloxacin, 8-3500 and 8.1-1500 ng mL-1 for ciprofloxacin, 6.2-3500 and 13-1500 ng mL-1 for danofloxacin, 7.4-3500 and 8.4-1500 ng mL-1 for enrofloxacin, 14-3500 and 20-2000 ng mL-1 for sarafloxacin, 12.5-3500 and 13.9-1200 ng mL-1 for difloxacin, 7.6-3500 and 13-3000 ng mL-1 for oxolinic acid, and 9-2000 and 130-3000 ng mL-1 for flumequine. Limit of detection values obtained using FL and TR modes, respectively, were 60 and 95 ng mL-1 for marbofloxacin, 2 and 2.4 ng mL-1 for ciprofloxacin, 1.9 and 3.9 ng mL-1 for danofloxacin, 2.2 and 2.5 ng mL-1 for enrofloxacin, 3.8 and 7 ng mL-1 for sarafloxacin, 4 and 4.2 ng mL-1 for difloxacin, 2.3 and 4 ng mL-1 for oxolinic acid, and 2.7 and 40 ng mL-1 for flumequine. The precision was established at two concentration levels of each analyte and expressed as the percentage of relative standard deviation with values ranging between 1.9 and 7.8%. The validation procedure for the analysis of samples was carried out using European Community recommendations, and the decision limit and detection capability were calculated for bovine whole milk. The method was applied to whole, semiskimmed, and skimmed milk samples spiked with the target analytes, and the recoveries ranged between 93.3 and 106.0%.

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“…This strategy proved to be necessary in order to avoid filling the coordination sphere with solvent molecules, represented in most cases by water, which will result in non-radiative deactivations. These ligands create a sheath around the complex, assuring desolvation [85], or can fill in the coordination sphere of the lanthanide ion [86]. Moreover, the removal of oxygen atoms from the coordination sphere enhances luminescence [87][88][89].…”

Section: Quantitative Determination Of Quinolonesmentioning

confidence: 99%

Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

2020

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Quinolones comprise a series of synthetic bactericidal agents with a broad spectrum of activity and good bioavailability. An important feature of these molecules is their capacity to bind metal ions in complexes with relevant biological and analytical applications. Interestingly, lanthanide ions possess extremely attractive properties that result from the behavior of the internal 4f electrons, behavior which is not lost upon ionization, nor after coordination. Subsequently, a more detailed discussion about metal complexes of quinolones with lanthanide ions in terms of chemical and biological properties is made. These complexes present a series of characteristics, such as narrow and highly structured emission bands; large gaps between absorption and emission wavelengths (Stokes shifts); and long excited-state lifetimes, which render them suitable for highly sensitive and selective analytical methods of quantitation. Moreover, quinolones have been widely prescribed in both human and animal treatments, which has led to an increase in their impact on the environment, and therefore to a growing interest in the development of new methods for their quantitative determination. Therefore, analytical applications for the quantitative determination of quinolones, lanthanide and miscellaneous ions and nucleic acids, along with other applications, are reviewed here.

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Sensitive Determination of Fluoroquinolone Antibiotics in Milk Samples Using Time‐Resolved Methodology

Cited by 13 publications

References 18 publications

Effect of terbium(III) chloride on the micellization properties of sodium decyl- and dodecyl-sulfate solutions

Effect of terbium(III) chloride on the micellization properties of sodium decyl- and dodecyl-sulfate solutions

Determination of Fluoroquinolones in Milk Samples by Postcolumn Derivatization Liquid Chromatography with Luminescence Detection

Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

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