Sensitive Determination of Imatinib Mesylate in Human Plasma Using DABCO-Based Ionic Liquid-Modified Magnetic Nanoparticles

Sahebi, Hamed; Konoz, Elaheh; Ezabadi, Ali; Ниази, Али; Ahmadi, Seyyed Hamid

doi:10.1007/s10337-020-03923-x

Cited by 13 publications

(7 citation statements)

References 43 publications

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“…The properties of DABCO ILs and its derivatives make them a very promising class of materials for a wide range of applications such as, catalysis included a complexing ligand in the Suzu-ki-Miyaura reaction and the Sonogashira coupling, metal absorbents from aqueous solutions, potent antimicrobial and antibacterial agents, gas sorption and separation, optical, building units of excellent molecular ferroelectrics, electronic devices field and in the synthesis of metal-organic frameworks (MOFs) [3][4][5][6][7]. These DABCO materials are facile to prepare from commercially available and relatively inexpensive eco-friendly, high reactive, easy to handle and non-toxic base catalyst for various organic transformations [8]. The chemical reaction of these DABCO with alkyl halides yields transfer of the alkyl group to the DABCO and results in an alkylated DABCO halide -based ionic liquids [9][10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, molecular structure, and properties of DABCO bromide based ionic liquid combining spectroscopic studies with DFT calculations

Fetouhi

Haddad

Brandán

et al. 2021

Journal of Molecular Structure

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A new DABCO-based ionic liquid, namely 1-octyl-1,4-diazabicyclo [2.2.2] octan-1-ium Bromide ([C 8 DABCO + ][Br -]) has been synthesized through N-alkylation of 1,4-diazabicyclo [2.2.2] octane with 1-bromooctane using a simple procedure in one step. This [C 8 DABCO + ] [Br -] IL was characterized by FT-IR, FT-Raman and by 1 H and 13 C-NMR spectroscopies. The structure of [C 8 DABCO + ][Br -] IL was confirmed combining 1 H and 13 C-NMR spectroscopies with B3LYP/6-31G* calculations. Three ionic C-H•••Br bonds were predicted by natural bond orbital (NBO), atoms in molecules (AIM) calculations and bond orders but a monodentate coordination between cation and anion is suggested because only one of them has higher energy and lower distance. The effect of Br on properties of IL is clearly observed by the change in orientation and direction of dipole moment vector in the IL, as compared with the cation. NBO studies reveal that the Br anion strongly stabilizes to cation to form the IL. The complete vibrational assignments of 129 and 132 vibration modes expected for the cation and its IL were performed by using two harmonic force fields with the SQMFF methodology and transferable scaling factors. The scaled harmonic force constants were also reported for both species. The Br confers a higher reactivity to [C 8 DABCO + ][Br -], as suggested by analyses of frontier orbitals. The effect of Br is also observed in the different assignments observed for the IL and its cation. Reasonable correlations were found between the experimental IR, Raman and NMR spectra and the corresponding theoretical ones.

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Section: Introductionmentioning

confidence: 99%

Synthesis, molecular structure, and properties of DABCO bromide based ionic liquid combining spectroscopic studies with DFT calculations

Fetouhi

Haddad

Brandán

et al. 2021

Journal of Molecular Structure

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“…The models with a lack-of-fit (LOF) higher than 0.05 and a correlation coefficient greater than 0.98 proved that they had acceptable precision and reliability. 19 No significant LOF values existed for any of the experiments ( p > 0.05). Across all predictions, the adjusted R 2 and predicted R 2 values were not significantly different (differences less than 0.2%).…”

Section: Resultsmentioning

confidence: 85%

“…Additionally, DABCO-based ILs have excellent yields and are nontoxic, inexpensive, and environmentally friendly. 19 In this report, magnetite NP-modied DABCOnium-based Brønsted acidic ILs were synthesized and characterized by different techniques. As new adsorbents, the synthesized magnetic NPs were investigated for their ability to simultaneously extract and enrich trace metals (cadmium, chromium, nickel, and lead) from sunblock cream samples.…”

Section: Introductionmentioning

confidence: 99%

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Risk assessment of trace metals in sunblock creams using DABCOnium-based ionic liquid–functionalized magnetic nanoparticles

Hedayatafza,

Aberoomand Azar,

Sahebi

2023

Anal. Methods

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“…They obtained incrementing attention in analytical chemistry since they possess a high capacity to interact with other molecules via various interactions [29,30]. They are extensively utilized in samples pre-treating methods [31][32][33]. Therefore, modifying magnetic NPs with ILs can integrate the advantages of magnetic NPs to ILs and increase the extraction efficiency for some analytes [34].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Solid-Phase Extraction using Ionic Liquid-Modified Magnetic Nanoparticles for The Simultaneous Extraction of Cadmium and Lead in Milk Samples; Evaluation of Measurement Uncertainty

et al. 2021

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Abstract. In the present study, a new, sensitive, and rapid method was developed for extraction and determination of the trace amounts of Pb (II) and Cd (II) ions in milk samples through magnetic solid-phase extraction using DABCO based-ionic liquid-modified magnetic nanoparticles (Fe3O4/[DABCO-PDO]Cl NPs). Herein, Pb (II) and Cd (II) contents were quantified with flame atomic absorption spectroscopy (FAAS). The effect of different empirical parameters (such as sample pH, adsorbent amount, type and amount of the elution, extraction and desorption times, and the ligand concentration) was evaluated and optimized for simultaneous extraction and pre-concentration Pb (II) and Cd (II) ions. The calibration curve was linear under the optimum condition in the concentration range of 0.4-200 µgL-1 for Cd, and 0.5-120 µgL-1 for Pb, respectively. The pre-concentration factor was 67, with the detection limit of 0.09 and 0.07 µgL-1 for Pb and Cd, respectively. The relative standard deviation values (RSD %) of the proposed method were lower than 2.6 %. The developed method was successfully used to determine lead and cadmium content in milk samples. The information obtained from the method validation has been used to estimate the expanded uncertainty for the determination of Pb (II) and Cd (II) at trace levels in commercial milks. Resumen. En este trabajo, se ha desarrollado un nuevo, sensible y rápido procedimiento para la extracción y determinación de iones Pb(II) y Cd(II) a nivel de trazas en leche, mediante extracción en fase sólida utilizando nanopartículas magnéticas modificadas con líquido iónico basado en DABCO (Fe3O4/[DABCO-PDO]Cl NPs). La determinación de ambos metales se llevó a cabo por espectrometría de absorción atómica con atomización en llama. Se ha evaluado el efecto de diferentes parámetros empíricos (tales como pH, cantidad de adsorbente, tipo y cantidad de solvente de elución, tiempo de extracción y desorción, y concentración del ligando); estos parametros fueron optimizados enfocándose en la extracción y preconcentración simultanea de ambos iones. Empleando las condiciones establecidas, se obtuvo buena linealidad de las curvas de calibración en el intervalo de concentraciones 0.4-200 µgL-1 para Cd, y 0.5-120 µgL-1 para Pb, respectivamente. Se logró el factor de preconcentración 67, con los límites de detección 0.09 y 0.07 µgL-1 para Pb y Cd, respectivamente. Los valores de desviación estandar relativa (RSD %) en el procedimiento propuesto no sobrepasaron 2.6 %. En el análisis de leche, se obtuvieron resultados satisfactorios. Los datos obtenidos en etapa de validación se utilizaron para estimar la incertidumbre expandida en la determinación de Pb y Cd a nivel de trazas en leche.

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Sensitive Determination of Imatinib Mesylate in Human Plasma Using DABCO-Based Ionic Liquid-Modified Magnetic Nanoparticles

Cited by 13 publications

References 43 publications

Synthesis, molecular structure, and properties of DABCO bromide based ionic liquid combining spectroscopic studies with DFT calculations

Synthesis, molecular structure, and properties of DABCO bromide based ionic liquid combining spectroscopic studies with DFT calculations

Risk assessment of trace metals in sunblock creams using DABCOnium-based ionic liquid–functionalized magnetic nanoparticles

Magnetic Solid-Phase Extraction using Ionic Liquid-Modified Magnetic Nanoparticles for The Simultaneous Extraction of Cadmium and Lead in Milk Samples; Evaluation of Measurement Uncertainty

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