Sensitive determination of kaempferol in rat plasma by high-performance liquid chromatography with chemiluminescence detection and application to a pharmacokinetic study

Zhang, Qunlin; Zhang, Yunjing; Zhang, Z.; Lu, Zi-Dong

doi:10.1016/j.jchromb.2009.08.046

Cited by 38 publications

(19 citation statements)

References 33 publications

(47 reference statements)

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“…This indicates that the fluorescence intensity of C-dos is dependent on pH. Such observations are similar to those of C-dots modified with hydroxyl and carboxylic moieties [56,57]. Fig.…”

Section: Effect Of Ph and Reaction Timesupporting

confidence: 76%

Sensitive determination of kaempferol using carbon dots as a fluorescence probe

Liu

Feng

Paau

et al. 2015

Talanta

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“…This indicates that the fluorescence intensity of C-dos is dependent on pH. Such observations are similar to those of C-dots modified with hydroxyl and carboxylic moieties [56,57]. Fig.…”

Section: Effect Of Ph and Reaction Timesupporting

confidence: 76%

Sensitive determination of kaempferol using carbon dots as a fluorescence probe

Liu

Feng

Paau

et al. 2015

Talanta

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“…The variation coefficients are less than 2.0% indicating that the method is precise and confidence. Table 3 B compares the detection limit of the proposed method with the other reported methods [25,28,29,31]. It is obvious that the sensitivity of the method is superior to all previously reported methods.…”

Section: Accuracy Precision and Reproducibilitymentioning

confidence: 91%

“…1) contains flavonoid ring which contains electrochemically oxidisible groups in the flavone moiety which prompted us to study its electrochemical behavior at multi-walled carbon nanotube modified carbon paste electrode using cyclic voltammetry (CV) and square wave voltammetry (SWV) for developing a fast and sensitive square wave voltammetric (SWV) procedure for their determination. Various voltammetric [23][24][25] and chromatographic methods [26][27][28][29][30][31] for the determination of kaempferol in different biological samples have been reported in the literature. However, there is no report for its determination at MWCNTmodified CPE, particularly in presence of quercetin.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Electrochemical behavior of kaempferol and its determination in presence of quercetin employing multi-walled carbon nanotube modified carbon paste electrode

Dar

Naikoo

Hassan

et al. 2015

Analytical Chemistry Research

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Electrochemical behavior of kaempferol and its determination in presence of quercetin employing multiwalled carbon nanotube modified carbon paste electrode, Analytical Chemistry Research (2015), Abstract Electrocatalytic oxidation of kaempferol in presence of quercetin using multiwalled carbon nanotubes modified carbon paste electrode (MWCNTs/CPE) in phosphate buffer of pH 7.73. AbstractThe electrochemical behavior of kaempferol was investigated by cyclic voltammetry (CV) and square wave voltammetry (SWV) at plane and multiwalled carbon nanotubes modified carbon paste electrode (MWCNTs/CPE). Kaempferol produces an anodic peak at MWCNTs modified CPE with a quasi-reversible nature in phosphate buffer of pH 7.73. The oxidized species of kaempferol was found to be stable (Ip a /Ip c ≈1) over scan rates of 100~600 mVs -1 . The same electrode was also found to catalyze the electrode oxidation of quercetin in presence of kaempferol under similar conditions which enabled the simultaneous determination of kaempferol and quercetin. Linearity of peak currents (Ip) vs. concentrations of kaempferol and quercetin was found in the range of 6.72 x 10 -9 M to 40.34 x 10 -9 M with a detection limit of 2.90 x 10 -9 M for kaempferol and 13.0 x 10 -9 M to 50.9 x 10 -9 M with a detection limit of 3.5 x 10 -9 M for quercetin using fast and sensitive SWV. The developed method has been applied for the quantitative analysis of kaempferol in corms and petals of Indian traditional medicine saffron (Crocus sativus) using a phosphate buffer of pH 7.73 and the average percent recoveries obtained are 99.84 and 99.26, respectively.

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“…The strategies aimed at improving the drug absorption can be realized mainly through regulating the physiology conditions of gastrointestinal tract, especially by altering the expression of intestinal drug transporters as well as by inhibiting or inducing cytochrome P450 enzymes (CYPs), which expressed in the human hepatic and intestinal. For example, bacteria in the intestine may play a signi¿cant role in the metabolism of flavonoids (Lu et al, 2013;Yang et al, 2012;Zhang et al, 2009).…”

Section: Double Peak Phenomenonmentioning

confidence: 99%