Abstract:Perovskite-modified electrodes have received increasing attention in the last decade, due to their electrocatalytic properties to undergo the sensitive and selective detection of bioactive molecules, such as hydrogen peroxide, glucose, and dopamine. In this review paper, different types of perovskites involved for their electrocatalytic properties are described, and the proposed mechanism of detection is presented. The analytical performances obtained for different electroactive molecules are listed and compar… Show more
“…A schematic representation of the diffusion, adsorption, and electrochemical reaction processes between the sensing material and the analyte is shown in Fig. 11 91 , 92 . Figure 11 Schematic representation of the diffusion, adsorption, and electrochemical reaction processes between the sensing material and analyte.…”
Section: Resultsmentioning
confidence: 99%
“…A schematic representation of the diffusion, adsorption, and electrochemical reaction processes between the sensing material and the analyte is shown in Fig. 11 91,92 .…”
Section: Electrochemical Properties and Electrocatalytic Activity Of ...mentioning
Acetylcholine (ACh) plays a pivotal role as a neurotransmitter, influencing nerve cell communication and overall nervous system health. Imbalances in ACh levels are linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. This study focused on developing electrochemical sensors for ACh detection, utilizing graphene oxide (GO) and a composite of reduced graphene oxide and zinc oxide (rGO/ZnO). The synthesis involved modified Hummers' and hydrothermal methods, unveiling the formation of rGO through deoxygenation and the integration of nano-sized ZnO particles onto rGO, as demonstrated by XPS and TEM. EIS analysis also revealed the enhancement of electron transfer efficiency in rGO/ZnO. Cyclic voltammograms of the electrode, comprising the rGO/ZnO composite in ACh solutions, demonstrated prominent oxidation and reduction reactions. Notably, the composite exhibited promise for ACh detection due to its sensitivity, low detection threshold, reusability, and selectivity against interfering compounds, specifically glutamate and gamma-aminobutyric acid. The unique properties of rGO, such as high specific surface area and electron mobility, coupled with ZnO's stability and catalytic efficiency, contributed to the composite's potential in electrochemical sensor applications. This research, emphasizing the synthesis, fabrication, and characterization of the rGO/ZnO composite, established itself as a reliable platform for detecting the acetylcholine neurotransmitter.
“…A schematic representation of the diffusion, adsorption, and electrochemical reaction processes between the sensing material and the analyte is shown in Fig. 11 91 , 92 . Figure 11 Schematic representation of the diffusion, adsorption, and electrochemical reaction processes between the sensing material and analyte.…”
Section: Resultsmentioning
confidence: 99%
“…A schematic representation of the diffusion, adsorption, and electrochemical reaction processes between the sensing material and the analyte is shown in Fig. 11 91,92 .…”
Section: Electrochemical Properties and Electrocatalytic Activity Of ...mentioning
Acetylcholine (ACh) plays a pivotal role as a neurotransmitter, influencing nerve cell communication and overall nervous system health. Imbalances in ACh levels are linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. This study focused on developing electrochemical sensors for ACh detection, utilizing graphene oxide (GO) and a composite of reduced graphene oxide and zinc oxide (rGO/ZnO). The synthesis involved modified Hummers' and hydrothermal methods, unveiling the formation of rGO through deoxygenation and the integration of nano-sized ZnO particles onto rGO, as demonstrated by XPS and TEM. EIS analysis also revealed the enhancement of electron transfer efficiency in rGO/ZnO. Cyclic voltammograms of the electrode, comprising the rGO/ZnO composite in ACh solutions, demonstrated prominent oxidation and reduction reactions. Notably, the composite exhibited promise for ACh detection due to its sensitivity, low detection threshold, reusability, and selectivity against interfering compounds, specifically glutamate and gamma-aminobutyric acid. The unique properties of rGO, such as high specific surface area and electron mobility, coupled with ZnO's stability and catalytic efficiency, contributed to the composite's potential in electrochemical sensor applications. This research, emphasizing the synthesis, fabrication, and characterization of the rGO/ZnO composite, established itself as a reliable platform for detecting the acetylcholine neurotransmitter.
“…In this sense, perovskites are materials able to retain a three-dimensional network microstructure while keeping large amounts of oxygen vacancies and accommodating different metallic elements within the lattice structure [55]. A recent review established that the mechanism for glucose electro-oxidation in perovskites is complex and similar to the mechanism of H 2 O 2 electrooxidation [56]. This mechanism is known as the lattice-oxygen-mediated oxygen evolution reaction (LOM-OER), which involves the partial substitution of the cations of the A sites by divalent cations from group IIA of the periodic table, which can oxidize the cations of the B sites.…”
Section: Sensing Of Glucosementioning
confidence: 99%
“…They found that La 0.6 Ca 0.4 Ni 0.7 Fe 0.3 O 3 perovskite presented a relatively high specific surface area and good response in the sensing of H 2 O 2 in the range of 0.01-1 mM. In the A 2 BO 4+δ type perovskite containing Pr 1.92 Ba 0.08 Ni 0.95 Zn 0.05 O 4+δ , the presence of Pr 2 O 3 promotes the formation of defects in the crystal lattice of the A sites, as the partial substitution of Pr by Ba causes the disproportionation (oxidation-reduction reaction) of the B sites from Ni III to Ni II and Ni IV [56]. The perovskite material was deposited on a gold electrode employed as a working electrode, and the performance of the glucose sensor showed a dynamic range of 1.5-7000 µM, detection limit of 0.5 µM, and no interference for glucose detection in human serum.…”
The importance of biomarker quantification in technology cannot be overstated. It has numerous applications in medical diagnostics, drug delivery, and the timely implementation of prevention and control strategies for highly prevalent diseases worldwide. However, the discovery of new tools for detection has become increasingly necessary. One promising avenue is the use of perovskite-based materials, which exhibit excellent catalytic activity and redox properties. These make them ideal candidates for the development of electrochemical sensors. In this review, the advances of purely non-enzymatic electrochemical detection of bio-analytes, with ABO3 perovskite form, are presented. The work allows the visualization of some of the modifications in the composition and crystal lattice of the perovskites and some variations in the assembly of the electrodes, which can result in systems with a better response to the detection of analytes of interest. These findings have significant implications for improving the accuracy and speed of biomarker detection, ultimately benefiting patients and healthcare professionals alike.
“…As a result, enzyme-free glucose sensors have attracted substantial attention in the nanotechnology field, thanks to their several advantages such as long-term stability, ease of operation, cost-effectiveness, and portability [10,11]. For instance, the perovskite-based electrochemical biosensors for glucose detection have been currently presented in literature [12]. The perovskites formulated as ABO 3 (A, alkali metal or a lanthanide; B, transition metal; and O, oxygen ion) demonstrate good electrocatalytic effect against bioactive molecules such as glucose and dopamine [13][14][15].…”
A novel molecularly imprinted electrochemical biosensor for glucose detection is reported based on a hierarchical N-rich carbon conductive-coated TNO structure (TNO@NC). Firstly, TNO@NC was fabricated by a novel polypyrrole-chemical vapor deposition (PPy-CVD) method with minimal waste generation. Afterward, the electrode modification with TNO@ NC was performed by dropping TNO@NC particles on glassy carbon electrode surfaces by infrared heat lamp. Finally, the glucose-imprinted electrochemical biosensor was developed in presence of 75.0 mM pyrrole and 25.0 mM glucose in a potential range from + 0.20 to + 1.20 V versus Ag/AgCl via cyclic voltammetry (CV). The physicochemical and electrochemical characterizations of the fabricated molecularly imprinted biosensor was conducted by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD) method, X-ray photoelectron spectroscopy (XPS), electrochemical impedance spectroscopy (EIS), and CV techniques. The findings demonstrated that selective, sensitive, and stable electrochemical signals were proportional to different glucose concentrations, and the sensitivity of molecularly imprinted electrochemical biosensor for glucose detection was estimated to be 18.93 μA μM −1 cm −2 (R 2 = 0.99) at + 0.30 V with the limit of detection (LOD) of 1.0 × 10 −6 M. Hence, it can be speculated that the fabricated glucose-imprinted biosensor may be used in a multitude of areas, including public health and food quality.
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