Sensitive electrochemical determination of epinephrine at poly(L-aspartic acid)/electro-chemically reduced graphene oxide modified electrode by square wave voltammetry in pharmaceutics

Mekassa, Birhanu; Tessema, Merid; Chandravanshi, Bhagwan Singh; Baker, Priscilla; Muya, Francis Ntumba

doi:10.1016/j.jelechem.2017.11.045

Cited by 53 publications

(29 citation statements)

References 46 publications

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“…The detection (LOD) and quantification limits (LOQ) values for the DPV detection of EPI, obtained as the ratio between three and ten times the standard deviation of the blank signal and the sensitivity, were found to be 2.1 µM and 6.4 µM, respectively. In Supplementary Table S2, the LOD and linearity range of several electrochemical methods found in the literature for EPI determination are compared with our method [54][55][56][57][58][59][60][61][62][63][64][65][66][67] . As it can be observed, the developed sensor shows good analytical properties similar to those obtained for others also based on nanomaterials.…”

Section: Influence Of Epi Concentration In the Peak Currents: Analytimentioning

confidence: 99%

Chemically synthesized chevron-like graphene nanoribbons for electrochemical sensors development: determination of epinephrine

Sainz

Pozo

Vilas‐Varela

et al. 2020

Sci Rep

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We employ chevron-like graphene nanoribbons (GnRs) synthesized by a solution-based chemical route to develop a novel electrochemical sensor for determination of the neurotransmitter epinephrine (EPI). The sensor surface, a glassy carbon electrode modified with GNRs, is characterized by atomic force microscopy, scanning electron microscopy and Raman spectroscopy, which show that the electrode surface modification comprises of bi-dimensional multilayer-stacked GNRs that retain their molecular structure. the charge transfer process occurring at the electrode interface is

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Section: Influence Of Epi Concentration In the Peak Currents: Analytimentioning

confidence: 99%

Chemically synthesized chevron-like graphene nanoribbons for electrochemical sensors development: determination of epinephrine

Sainz

Pozo

Vilas‐Varela

et al. 2020

Sci Rep

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“…Similarly, catecholamine neurotransmitters (CNs) such as dopamine (DA), adrenaline (AD), and noradrenaline (NAD) play roles as messengers of neurological information [28]. Abnormal levels of CNs are related to various diseases including Parkinson's, Alzheimer's, schizophrenia, Huntington's chorea, severe head trauma, neuroblastoma, pituitary adenoma, adrenocortical carcinoma, pheochromocytoma, various cancerous tumors, and depression [29,30]. Therefore, the growth of a selective and sensitive technique for detecting CN is crucial.…”

Section: Introductionmentioning

confidence: 99%

Detection of Ferric Ions and Catecholamine Neurotransmitters via Highly Fluorescent Heteroatom Co-Doped Carbon Dots

Lee

Kim

et al. 2020

Sensors

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Carbon dots (CDs) demonstrate very poor fluorescence quantum yield (QY). In this study, with the help of a hydrothermal method, we combined CDs with nitrogen and phosphorus elements belonging to the VA group (in the periodic table) to form heteroatom co-doped CDs, i.e., nitrogen and phosphorus co-doped carbon dots (NPCDs). These displayed a significant improvement in the QY (up to 84%), which was as much as four times than that of CDs synthesized by the same method. The as-prepared NPCDs could be used as an “off-on” fluorescence detector for the rapid and effective sensing of ferric ions (Fe3+) and catecholamine neurotransmitters (CNs) such as dopamine (DA), adrenaline (AD), and noradrenaline (NAD). The fluorescence of NPCDs was “turned off” and the emission wavelength was slightly red-shifted upon increasing the Fe3+ concentration. However, when CNs were incorporated, the fluorescence of NPCDs was recovered in a short response time; this indicated that CN concentration could be monitored, relying on enhancing the fluorescence signal of NPCDs. As a result, NPCDs are considered as a potential fluorescent bi-sensor for Fe3+ and CN detection. Particularly, in this research, we selected DA as the representative neurotransmitter of the CN group along with Fe3+ to study the sensing system based on NPCDs. The results exhibited good linear ranges with a limit of detection (LOD) of 0.2 and 0.1 µM for Fe3+ and DA, respectively.

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“…Nevertheless, with the exception of PMaIG/MWCNT/GCE, the sensitivities reported here are higher, which represents an advantageous feature. The lowest limits of detection displayed in Table were achieved for sensors constructed with either nanocomposites or other compounds with less appealing characteristics, both in practical and economic terms. Furthermore, they do not fulfill the main requirements for modified electrode sensors, which are high performance, robustness, low cost and easy preparation.…”

Section: Resultsmentioning

confidence: 99%

Polymer/Iron Oxide Nanoparticle Modified Glassy Carbon Electrodes for the Enhanced Detection of Epinephrine

Tomé

Brett

2019

Electroanalysis

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Novel electrochemical sensors for epinephrine (EP) based on a glassy carbon electrode (GCE) modified with a redox polymer film and iron (III) oxide nanoparticles (Fe2O3NP) have been developed. Two redox polymers‐poly(brilliant cresyl blue) (PBCB) and poly(Nile blue) (PNB), and two different architectures‐polymer/Fe2O3/GCE and Fe2O3/polymer/GCE were investigated. The electrochemical oxidation of epinephrine at the modified electrodes was performed by differential pulse voltammetry (DPV), in pH 7 electrolyte, and the analytical parameters were determined. The results show enhanced performance, more sensitive responses and lower detection limits at the modified electrodes, compared to other electrochemical epinephrine sensors reported in the literature. The best voltammetric response with the lowest detection limit was obtained for the determination of epinephrine at PBCB/Fe2O3/GCE. The novel sensors are reusable, with good reproducibility and stability, and were successfully applied to the determination of epinephrine in commercial injectable adrenaline samples.

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Sensitive electrochemical determination of epinephrine at poly(L-aspartic acid)/electro-chemically reduced graphene oxide modified electrode by square wave voltammetry in pharmaceutics

Cited by 53 publications

References 46 publications

Chemically synthesized chevron-like graphene nanoribbons for electrochemical sensors development: determination of epinephrine

Chemically synthesized chevron-like graphene nanoribbons for electrochemical sensors development: determination of epinephrine

Detection of Ferric Ions and Catecholamine Neurotransmitters via Highly Fluorescent Heteroatom Co-Doped Carbon Dots

Polymer/Iron Oxide Nanoparticle Modified Glassy Carbon Electrodes for the Enhanced Detection of Epinephrine

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