Sensitive Non-Enzymatic Glucose Electrochemical Sensor Based on Electrochemically Synthesized PANI/Bimetallic Oxide Composite

Abstract

The development of a sensitive glucose monitoring system is highly important to protect human lives as high blood-glucose level-related diseases continue to rise globally. In this study, a glucose sensor based on polyaniline-bimetallic oxide (PANI-MnBaO2) was reported. PANI-MnBaO2 was electrochemically synthesized on the glassy carbon electrode (GCE) surface. The as-prepared PANI-MnBaO2 was characterized by field emission scanning electron microscopy, Fourier transform infrared spectroscopy, energy dispersive X-ray spectroscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. Glucose sensing on PANI-MnBaO2 is based on the electrocatalytic oxidation of glucose to the glucolactone, which gives oxidation current. The oxidation potential for glucose was 0.83 V, with a limit of detection of 0.06 µM in the linear and in the concentration range of 0.05 µM–1.6 mM. The generated current densities displayed excellent stability in terms of repeatability and reproducibility with fast response. The development of a sensitive glucose sensor as obtained in the current study would ensure human health safety and protection through timely and accurate glucose detection and monitoring.

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“…For example, a glucose biosensor based on MnO2/MWNTs composite was fabricated [21], which showed a linear dependence (R = 0.995) in the glucose concentration range up to 28 mM, having a sensitivity of 33.19 µA /mM and a significantly lower overvoltage. In another research work, a glucose sensor based on polyanilinebimetallic oxide (PANI-MnBaO2) was reported, which had a limit of detection of 0.06 µM in the concentration range of 0.05 µM-1.6 mM [22].…”

Recent Advances in Conductive Polymers-Based Electrochemical Sensors for Biomedical and Environmental Applications

“…Therefore, accurate and timely glucose detection is of paramount importance in safeguarding human lives. Electrochemical techniques have garnered significant attention for their cost-effectiveness, direct quantification capabilities, ease of miniaturization, and suitability for wearable devices compared to alternative methods such as colorimetry, optical coherence tomography, and near-infrared reflectance spectroscopy [ 81 , 82 , 83 , 84 , 85 ].…”

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“…Sousa et al [20] presented different microencapsulation strategies for general and essential oils, some extraction methods for essential oils, and their applications. Khan et al [21] highlight an essential issue for the safety and protection of human health, namely, timely and accurate glucose detection and monitoring. The authors developed sensitive and reliable electrochemical sensors for glucose determination to solve this problem using affordable and readily available materials.…”