Sensitive Quantitative Predictions of MHC Binding Peptide from Entamoeba Histolytica

Gomase, Virendra; Kapoor, Rinki; Ladak, S. S.; Khartode, Ravikiran

doi:10.1115/1.859797.paper9

Cited by 3 publications

(3 citation statements)

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“…The methods were used to analyze the antigenic peptide region of Cytochrome c oxidase subunit 2 (mitochondrion) are Hopp and Woods, Welling, Parker, Bepipred ,Kolaskar and Tongaonkar antigenicity methods [16][17][18][19][20][21][22][23][24][25][26][27][28].…”

Section: Protein Antigenicity Predictionmentioning

confidence: 99%

Prediction of MHC Binding Peptides and Antigenic Peptides from Ascaris lumbricoides

Mishra¹,

Gomase²

2016

J Autoimmune Disord

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The parasitic disease Ascariasis is the major concern because of its morbidity and mortality issue. In this investigation, we predicted the binding peptides of the MHC class I and MHC class II by Position Specific Scoring Matrices (PSSM) and Support Vector Machine (SVM) algorithms. We predicted the binding affinity of Cytochrome c oxidase subunit 2 (mitochondrion) having a 232 amino acids long residue sequence, which shows 224 nonamers. We predicted the peptide binding affinity to MHC I moles are as 8mer_H2_Db (The binding We also study integrates prediction of peptide MHC class I binding; proteasomal C terminal cleavage and TAP transport efficiency by using sequence and properties of the amino acids. We also found the binding of peptides to different alleles by using Position Specific Scoring Matrix. PSSM based server will predict the peptide binders of Cytochrome c oxidase subunit 2 from Ascaris lumbricoides sequence to, which are found antigenic epitopes region in protein.

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Section: Protein Antigenicity Predictionmentioning

confidence: 99%

Prediction of MHC Binding Peptides and Antigenic Peptides from Ascaris lumbricoides

Mishra¹,

Gomase²

2016

J Autoimmune Disord

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“…Where T helper cells trigger an immune response by inflammation and swelling due to phagocytes or may lead to an antibody-mediated immune response via B-cell activation. Since MHCs have a key role in immune system by stimulating cellular and humoral immunity against NADH dehydrogenase subunit 6 (mitochondrion) from D. medinensis and are used for controlling specific immunological processes by creating peptides to bind to specific MHC alleles and this binding affinity to specific peptides are used for designing synthetic peptide vaccines [37][38][39][40].…”

Section: Mhc Class II Antigenmentioning

confidence: 99%

SVM based Prediction of Major Histocompatibility Complex Binders: Identification and Analysis of Dracunculus medinensis Peptide

Mishra¹

2016

OMCIJ

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The largest human infecting parasite causes guinea worm disease, known as the disease and cause of poverty due to unavailability of the sanitized water. This is not lethal but causes the long term morbidity and motility in the infected human. In this research work, we predict the peptide binders of antigenic protein from D. medinensis sequence to MHC-I molecules are as 11mer_H2_Db, 10mer_H2_Db, 9mer_H2_Db, 8mer_H2_Db.Also study integrates prediction of peptide MHC class I binding; proteasomal C terminal cleavage and TAP transport efficiency by using sequence and properties of the amino acids. We also found the binding of peptides to different alleles by using Position Specific Scoring Matrix. NADH dehydrogenase subunit 6 (mitochondrion) from D. medinensis is 145 residues long with 137 nonamers having antigenic MHC binding peptides. PSSM based server will predict the peptide binders from D.medinensis of NADH dehydrogenase subunit 6 sequence to MHC-II molecules are as I_Ab.p, I_Ad.p, I_Ag7.p,I_Ak.p which are found antigenic epitopes region in NADH dehydrogenase subunit 6 (mitochondrion) from D. medinensis.

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“…MHC peptide complexes will be translocated on the surface of antigen presenting cells (APCs). This theme is implemented in developing subunit and synthetic peptide vaccines [4][5][6][7]. One of the important problems in subunit vaccine design is to search for antigenic regions in an antigen protein [8] that can stimulate T-cells called T-cell epitopes.…”

Section: Mhc Class Binding Peptidesmentioning

confidence: 99%

Prediction of Wuchereria Bancrofti Troponin Antigenic Peptides: Application in Synthetic Vaccine Design to Counter Lymphatic Filariasis

AS¹

2013

J Vaccines Vaccin

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Sensitive Quantitative Predictions of MHC Binding Peptide from Entamoeba Histolytica

Cited by 3 publications

References 0 publications

Prediction of MHC Binding Peptides and Antigenic Peptides from Ascaris lumbricoides

Prediction of MHC Binding Peptides and Antigenic Peptides from Ascaris lumbricoides

SVM based Prediction of Major Histocompatibility Complex Binders: Identification and Analysis of Dracunculus medinensis Peptide

Prediction of Wuchereria Bancrofti Troponin Antigenic Peptides: Application in Synthetic Vaccine Design to Counter Lymphatic Filariasis

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