Sensitive sensing of biomarkers in interstitial fluid

Kim, Youngeun; Prausnitz, Mark R.

doi:10.1038/s41551-020-00679-5

Cited by 34 publications

(24 citation statements)

References 15 publications

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“…[ 140 ] It also provides new clinically valuable biomarkers. [ 87,128 ] Placing the biosensor inside the human body represents a powerful platform for continuous monitoring of biomarkers reducing environmental interferences. [ 9 ] Using optical biosensors avoid the necessity of electrical power nor recharging.…”

Section: Discussionmentioning

confidence: 99%

“…[ 127 ] It can be reduced by modifying the sensor surface to prevent non‐specific interactions or by antibiofouling membranes. [ 17 ] Physiological components can also produce optical signals that can interfere with the measurement of the biomarker of interest, [ 72,128 ] is extremely important to achieve high signal‐to‐background ratios by using high‐precision devices. [ 62,71 ] The influence of the anatomical location of the tattoo, the tattoo implantation depth and the skin differences between ethnicity, age, sexual hormonal impact, climate, and diet should be studied.…”

Section: Future Perspectives and Challengesmentioning

confidence: 99%

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Tattoo Inks for Optical Biosensing in Interstitial Fluid

Pazos

Elani

et al. 2021

Adv Healthcare Materials

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The persistence of traditional tattoo inks presents an advantage for continuous and long‐term health monitoring in point of care devices. The replacement of tattoo pigments with optical biosensors aims a promising alternative for monitoring blood biomarkers. Tattoo inks functionalization enables the control of interstitial biomarkers with correlated concentrations in plasma, to diagnose diseases, evaluate progression, and prevent complications associated with physio pathological disorders or medication mismatches. The specific biomarkers in interstitial fluid provide a new source of information, especially for skin diseases. The study of tattoo inks displays insufficient regulation in their composition, a lack of reports of the related complications, and a need for further studies on their degradation kinetics. This review focuses on tattoo optical biosensors for monitoring dermal interstitial biomarkers and discusses the clinical advantages and main challenges for in vivo implantation. Tattoo functionalization provides a minimally invasive, reversible, biocompatible, real‐time sensing with long‐term permanence and multiplexing capabilities for the control, diagnosis, and prevention of illness; it enables self‐controlling management by the patient, but also the possibility of sending the records to the doctor.

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Section: Discussionmentioning

confidence: 99%

Section: Future Perspectives and Challengesmentioning

confidence: 99%

Tattoo Inks for Optical Biosensing in Interstitial Fluid

Pazos

Elani

et al. 2021

Adv Healthcare Materials

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“…We should also emphasize that the applications of our HMN technology can be expanded to achieve on‐needle multiplexed detection of many other clinically relevant biomarkers such as cortisol, glucose, and lactate. [ 9,49 ] This can be achieved by combining recognition agents such as enzymes, aptamers, and antibodies into our HMN‐WE for use in electrochemical‐based assay detections.…”

Section: Discussionmentioning

confidence: 99%

A Conductive Hydrogel‐Based Microneedle Platform for Real‐Time pH Measurement in Live Animals

Odinotski

Dhingra

GhavamiNejad

et al. 2022

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Conventional microneedles (MNs) have been extensively reported and applied toward a variety of biosensing and drug delivery applications. Hydrogel forming MNs with the added ability to electrically track health conditions in real‐time is an area yet to be explored. The first conductive hydrogel microneedle (HMN) electrode that is capable of on‐needle pH detection with no postprocessing required is presented here. The HMN array is fabricated using a swellable dopamine (DA) conjugated hyaluronic acid (HA) hydrogel, and is embedded with poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) to increase conductivity. The catechol‐quinone chemistry intrinsic to DA is used to measure pH in interstitial fluid (ISF). The effect of PEDOT:PSS on the characteristics of the HMN array such as swelling capability and mechanical strength is fully studied. The HMN's capability for pH measurement is first demonstrated using porcine skin equilibrated with different pH solutions ranging from 3.5 to 9. Furthermore, the HMN‐pH meter is capable of in vivo measurements with a 93% accuracy compared to a conventional pH probe meter. This HMN technology bridges the gap between traditional metallic electrochemical biosensors and the direct extraction of ISF, and introduces a platform for the development of polymeric wearable sensors capable of on‐needle detection.

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“…Hollow microneedles sample ISF by extraction, whereas microneedles constructed of a porous material absorb the surrounding fluid. Alternatively, the microneedles can serve as solid penetration structures, with the analysis occurring on the surface of the needles by optical or electrochemical means 73 . Depending on the application, microneedle devices can be designed for continual ISF sampling, although the total time of use is typically hours to a day.…”

Section: Assembling Wearable Devicesmentioning

confidence: 99%

End-to-end design of wearable sensors

et al. 2022

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Wearable devices provide an alternative pathway to clinical diagnostics by exploiting various physical, chemical and biological sensors to mine physiological (biophysical and/or biochemical) information in real time (preferably, continuously) and in a non-invasive or minimally invasive manner. These sensors can be worn in the form of glasses, jewellery, face masks, wristwatches, fitness bands, tattoo-like devices, bandages or other patches, and textiles. Wearables such as smartwatches have already proved their capability for the early detection and monitoring of the progression and treatment of various diseases, such as COVID-19 and Parkinson disease, through biophysical signals. Next-generation wearable sensors that enable the multimodal and/or multiplexed measurement of physical parameters and biochemical markers in real time and continuously could be a transformative technology for diagnostics, allowing for high-resolution and time-resolved historical recording of the health status of an individual. In this Review, we examine the building blocks of such wearable sensors, including the substrate materials, sensing mechanisms, power modules and decision-making units, by reflecting on the recent developments in the materials, engineering and data science of these components. Finally, we synthesize current trends in the field to provide predictions for the future trajectory of wearable sensors.

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Sensitive sensing of biomarkers in interstitial fluid

Abstract: POINT-OF-CARE DIAGNOSTICS Sensitive sensing of biomarkers in interstitial fluidA minimally invasive microneedle patch detects specific protein biomarkers in dermal interstitial fluid at high sensitivity via a needle-integrated immunoassay coupled with an ultrabright fluorescent label.

Cited by 34 publications

References 15 publications

Tattoo Inks for Optical Biosensing in Interstitial Fluid

Tattoo Inks for Optical Biosensing in Interstitial Fluid

A Conductive Hydrogel‐Based Microneedle Platform for Real‐Time pH Measurement in Live Animals

End-to-end design of wearable sensors

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