Sensitive skin at menopause; dew point and electrometric properties of the stratum corneum

Paquet, F.; Piérard-Franchimont, C; Fumal, I.; Goffin, Veroniqué; Paye, Marc; Pierard, Gérald

doi:10.1016/s0378-5122(97)00079-0

Cited by 65 publications

(64 citation statements)

References 9 publications

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“…Some electrometric devices are available to measure the water flux and retention inside the SC [28, 32]. The passive sustainable hydration test during occlusion by the sensor probe allows the objective evaluation of such physiological variables [30,31,32,33,34,35]. However, as yet there are no studies using this method to obtain an index of water barrier maturation in atopic dermatitis.…”

Section: Discussionmentioning

confidence: 99%

“…The volunteers rested in the test room for 30 min before measurements. A Nova Dermal Phase Meter (DPM) 9003 equipped with a sensor probe DPM 9103 (Nova, Gloucester, Mass., USA) was used to measure the electrical impedance-based capacitance of the skin [28,29,30,31,32,33]. Values were expressed as DPM units (DU).…”

Section: Methodsmentioning

confidence: 99%

“…Any alteration in the skin barrier function results in increased values of RWA 30 and/or delayed RWA [28,29,30,31,32,33]. …”

Section: Methodsmentioning

confidence: 99%

“…The resulting changes in hydration alter the electrical properties of the SC by increasing the capacitance, conductance and impedance values. The dynamics of this physiological response may be studied by measuring, in continuous mode, the variations in electrometric properties of the skin surface occluded by a specially designed meter probe [30,31,32,33,34,35]. …”

Section: Introductionmentioning

confidence: 99%

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Comparative Effect of Tacrolimus and Betamethasone Valerate on the Passive Sustainable Hydration of the Stratum Corneum in Atopic Dermatitis

et al. 2007

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Background: There is ample evidence that the skin barrier function is altered in atopic dermatitis. Little information is available about the effect of topical corticosteroids and calcineurin inhibitors on this function. Purpose: To assess the water content and its rate of accumulation in the stratum corneum of atopic patients using an indirect electrometric method while on tacrolimus or betamethasone valerate treatment. Method: Twenty-one patients with moderate atopic dermatitis affecting both forearms completed this double-blind randomized study. One forearm was treated twice daily for 3 weeks with 0.1% tacrolimus ointment. The other forearm was similarly treated with 0.12% betamethasone valerate ointment. Electrometric measurements were made under continuous occlusion secured by a Nova Dermal Phase Meter sensor probe. Assessments were performed at inclusion, after the 3-week treatment and after a further 3-week follow-up out of treatment. Results: During treatment, both compounds yielded a similar improvement in skin barrier function. Indeed, under probe occlusion, the rate of water accumulation was significantly decreased. This improvement was sustained after stopping the tacrolimus treatment. By contrast, the benefit was in part lost at the site that had been treated by betamethasone valerate. Conclusion: The difference in the effect of the 2 compounds may be due to the negative influence of betamethasone valerate on the epidermal metabolism leading to progressive atrophy of the tissue. The better preservation of the skin barrier function after stopping tacrolimus treatment may help retarding relapses of atopic dermatitis.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Any alteration in the skin barrier function results in increased values of RWA 30 and/or delayed RWA [28,29,30,31,32,33]. …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative Effect of Tacrolimus and Betamethasone Valerate on the Passive Sustainable Hydration of the Stratum Corneum in Atopic Dermatitis

et al. 2007

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“…This condition results from an altered desquamation process that is often associated with decreased hydration of the upper layers of the stratum corneum and with weakening of the barrier function of the skin. Both the skin water-holding capacity and the barrier function of the stratum corneum appear to increase following HRT [20,21].…”

Section: Hrt and Skin Epitheliamentioning

confidence: 99%

Downgrading skin climacteric aging by hormone replacement therapy

Quatresooz

Pierard

2007

Expert Review of Dermatology

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For years, hormone replacement therapy (HRT) for menopausal women appeared straightforward for the believers. It markedly improved climacteric changes in many organs, including the skin. However, emerging information suggested that combined HRT increased the risks of cardiovascular diseases and invasive breast cancer [1,2]. Many healthcare providers and women were soon impressed by the alarmist lay press regarding the use of these hormones. These pessimistic views were more recently challenged. Indeed, it was demonstrated that the administration of estrogens alone in hysterectomized women did not significantly increase the incidence of coronaropathies and breast cancer [3]. The bulk of recent studies also confirmed that estrogens or estroprogestins effectively suppress the climacteric syndrome and genital atrophy, while significantly decreasing the risk of osteoporotic fractures. The cardiovascular risk appears more prominent in late menopausal HRT users than in early menopause, and the risk of venous thromboembolism can be reduced strongly by using transdermal instead of oral estrogens [4]. Regarding the risk of breast cancer, the additional absolute risk of postmenopausal women using estroprogestins is only 0.08 per 100 women per year, whereas estrogens alone do not increase the risk [3,5].

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Skin barrier repair after contact burns. electrometric evaluation using the passive sustainable hydration test

Cromphaut

Fumal

Jacquemin³

et al. 1999

J. Environ. Med.

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Sensitive skin at menopause; dew point and electrometric properties of the stratum corneum

Cited by 65 publications

References 9 publications

Comparative Effect of Tacrolimus and Betamethasone Valerate on the Passive Sustainable Hydration of the Stratum Corneum in Atopic Dermatitis

Comparative Effect of Tacrolimus and Betamethasone Valerate on the Passive Sustainable Hydration of the Stratum Corneum in Atopic Dermatitis

Downgrading skin climacteric aging by hormone replacement therapy

Skin barrier repair after contact burns. electrometric evaluation using the passive sustainable hydration test

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