Sensitive time-windows for susceptibility in neurodevelopmental disorders

FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry

“…Transient developmental delays of neuronal and synaptic phenotypes in the Fmr1 −/− model have been observed in postnatal developmental stages in neocortex 40,41 . Our data reveal a previously undescribed prenatal cortical phenotype.…”

Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model

“…Despite extensive knowledge of critical periods for the development of sensorimotor networks, much less is known about the critical periods for complex behaviors in neurodevelopmental disorders (9,10). An inducible mouse model for Rett syndrome showed that adult activation of the Mecp2 gene could rescue behavioral alterations and synaptic plasticity deficits, suggesting a broad window of therapeutic opportunity (11).…”

Bilirubin-induced neural impairment: A special focus on myelination, age-related windows of susceptibility and associated co-morbidities

“…In addition, since exposure to early adverse lifeevents and their timing during neural circuit formation may exert powerful and potentially long-term effects that depend on whether they occur during the embryonic period or during the first postnatal week, it is suggested that distinct therapeutic interventions are required [16]. Studies developed in mice have shown that the window of high bilirubin toxicity is between P0 and P8 [17], which corresponds to the human preterm period between 20 and 32 weeks of gestation [18].…”