2021
DOI: 10.1371/journal.pone.0257395
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Sensitive timing of undifferentiation in oligodendrocyte progenitor cells and their enhanced maturation in primary visual cortex of binocularly enucleated mice

Abstract: Sensory experience modulates proliferation, differentiation, and migration of oligodendrocyte progenitor cells (OPCs). In the mouse primary visual cortex (V1), visual deprivation-dependent modulation of OPCs has not been demonstrated. Here, we demonstrate that undifferentiated OPCs developmentally peaked around postnatal day (P) 25, and binocular enucleation (BE) from the time of eye opening (P14-15) elevated symmetrically-divided undifferentiated OPCs in a reversible G0/G1 state even more at the bottom lamina… Show more

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“…During nervous system development, there is a stage where Olig2 and nestin are coexpressed in certain neural precursor cells, representing a transitional state during their differentiation into oligodendrocytes . Furthermore, nestin is known to be expressed in early stages of neural development, including oligodendrocyte precursor cells (OPCs), and is gradually downregulated as OPCs differentiate into mature oligodendrocytes. , Therefore, the increased level of nestin expression in the single stimulus group suggests a transitional state of differentiation, indicating the presence of progenitor cells that have not fully differentiated into oligodendrocytes or glial cells. Hence, our results suggest that the combined application of NF and ES stimulation exerts a robust effect, facilitating the generation of functional neurons and promoting neurodevelopmental processes in human iPSCs.…”
Section: Resultsmentioning
confidence: 99%
“…During nervous system development, there is a stage where Olig2 and nestin are coexpressed in certain neural precursor cells, representing a transitional state during their differentiation into oligodendrocytes . Furthermore, nestin is known to be expressed in early stages of neural development, including oligodendrocyte precursor cells (OPCs), and is gradually downregulated as OPCs differentiate into mature oligodendrocytes. , Therefore, the increased level of nestin expression in the single stimulus group suggests a transitional state of differentiation, indicating the presence of progenitor cells that have not fully differentiated into oligodendrocytes or glial cells. Hence, our results suggest that the combined application of NF and ES stimulation exerts a robust effect, facilitating the generation of functional neurons and promoting neurodevelopmental processes in human iPSCs.…”
Section: Resultsmentioning
confidence: 99%