Sensitive voltammetric determination of epinephrine in the presence of acetaminophen at a novel ionic liquid modified carbon nanotubes paste electrode

Tavana, Toktam; Khalilzadeh, Mohammad A.; Karimi-Maleh, Hassan; Ensafi, Ali A.; Beitollahi, Hadi; Zareyee, Daryoush

doi:10.1016/j.molliq.2012.01.009

Cited by 201 publications

(80 citation statements)

References 68 publications

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“…The linear range of response and limit of detection were analyzed in comparison to electrochemical sensors to adrenaline reported in the literature (Table 1). [39][40][41][42][43][44][45][46][47][48][49][50][51] As can be seen, the BEDT-TTF/DNA/TiO 2 /ITO photoelectroanalytical sensor shows a linear range of response of four orders of magnitude and a limit of detection of 1 nmol L -1 , which were as good as the best electrochemical sensors to adrenaline. The precision of measurements using the BEDT-TTF/DNA/TiO 2 /ITO photoelectroanalytical sensor was investigated from intra-day and inter-day repeatability studies.…”

Section: Optimization Of the Bedt-ttf/dna/tio 2 Photoelectroanalyticamentioning

confidence: 84%

“…1 The level of adrenaline in the body affects a series of actions of the nervous system including the regulation of blood pressure, heart rate, lipolysis, immune response and glycogen metabolism. 2 In addition, adrenaline has been advocated during early cardiopulmonary resuscitation, early defibrillation and early advanced care in cardiac arrest for decades. 3 Therefore, the quantification of adrenaline in biological samples is of high interest nowadays.…”

Section: Introductionmentioning

confidence: 99%

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Photoelectroanalytical Detection of Adrenaline Based on DNA and TiO2 Nanoparticles Sensitized with Bis(ethylenedithio)tetrathiafulvalene Exploiting LED Light

Santos¹,

Neto²,

Macena³

et al. 2017

J. Braz. Chem. Soc.

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In this study, a photoelectroanalytical sensor for determination of adrenaline based on deoxyribonucleic acid (DNA) and anatase titanium dioxide (TiO 2 ) nanoparticles sensitized with bis(ethylenedithio)tetrathiafulvalene (BEDT-TTF) was developed, which we henceforward call BEDT-TTF/DNA/TiO 2 /ITO. The photoelectroanalytical sensor showed high photocurrent to adrenaline under visible light emitting diode (LED) light irradiation in comparison to each component of the composite material. Under optimized conditions, the BEDT-TTF/DNA/TiO 2 /ITO sensor shows a linear response range from 10 nmol L -1 up to 100 µmol L -1 with a sensitivity of 8.1 nA L µmol -1 and limit of detection of 1 nmol L -1 for the detection of adrenaline. The photoelectrochemical sensor showed high photocurrent to adrenaline in comparison to photocurrent response to ascorbic acid and uric acid. The BEDT-TTF/DNA/TiO 2 /ITO photoelectrochemical sensor was successfully applied to urine samples, with recovery values between 96 and 106%. Keywords: adrenaline, photoelectrochemical sensor, visible LED light, deoxyribonucleic acid IntroductionAdrenaline, also known as epinephrine, is one of the most important message transfer compound in the mammalian central nervous system, which exist as an organic cation in the nervous tissue and the biological body fluid. 1 The level of adrenaline in the body affects a series of actions of the nervous system including the regulation of blood pressure, heart rate, lipolysis, immune response and glycogen metabolism. 2 In addition, adrenaline has been advocated during early cardiopulmonary resuscitation, early defibrillation and early advanced care in cardiac arrest for decades. 3 Therefore, the quantification of adrenaline in biological samples is of high interest nowadays. Urine represents one of the most easily attainable and, consequently, very common samples in adrenaline clinical analysis and diagnostics. The levels of adrenaline in biological fluids such as urine depends on the age and condition of the patient. 4 For healthy people, for example, the physiological concentration of adrenaline found in urine samples are in nanomolar level (22-109 nmol L -1 ). 5A number of analytical methodologies have been proposed for determination of adrenaline such as fluorimetric, 6 spectrophotometric, 7 enzymatic radioimmunoassay, 8 gas chromatography, 9 high performance liquid chromatography, 10 capillary electrophoresis 11 and electrochemical methods. [12][13][14][15] Despite the high number of analytical methods for adrenaline determination, most of them suffer from some disadvantages such as high cost, long analysis time, extensive sample pretreatment based on derivatization, extraction and purification as well as demands for highly trained users. The fluorometric and radioenzymatic assays are presently the most widely used techniques for the estimation of plasma, urine and tissue adrenaline. The fluorometric assay lacks specificity and sensitivity. The radioenzymatic assay is significantly more sensitive and specific...

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Section: Optimization Of the Bedt-ttf/dna/tio 2 Photoelectroanalyticamentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Photoelectroanalytical Detection of Adrenaline Based on DNA and TiO2 Nanoparticles Sensitized with Bis(ethylenedithio)tetrathiafulvalene Exploiting LED Light

Santos¹,

Neto²,

Macena³

et al. 2017

J. Braz. Chem. Soc.

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“…In the past, the voltammetric sensor was developed based on nanomaterials in the presence of RTILs for drug and other important biological compound analysis [37][38][39][40][41][42][43][44][45][46][47]. TiC is representative transition metal carbide.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical determination of tryptophan at room-temperature ionic liquid-titanium carbide nanoparticle gel modified electrode

Zhang

Pan

et al. 2014

Ionics

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The novel gel composite, based on the ground o f i o n i c l i q u i d ( 1 -b u t y l -3 -m e t h y l i m i d a z o l i u m hexafluorophosphate, BMIMPF 6 ) and titanium carbide (TiC) nanoparticles, was used to modify glassy carbon electrode and applied to the electrochemical determination of tryptophan (trp). The physical and electrochemical characterizations of the BMIMPF 6 -TiC gel modified electrode were studied in detail by scanning electron microscopy, energy dispersive X-ray spectroscopy, cyclic voltammetry, and differential pulse voltammetry methods. Due to the large specific surface area and strong adsorption property of TiC nanoparticles, as well as the good ionic conductivity and strong electrocatalytic property of BMIMPF 6 , the oxidation peak current of trp at BMIMPF 6 -TiC gel modified electrode showed good linear relation with its concentrations ranging from 0.50 to 30 μmol/L and 30 to 500 μmol/L, respectively. The detection limit was 0.053 μmol/L. More importantly, the BMIMPF 6 -TiC gel modified electrode had good antiinterference ability and can be successfully applied in the electrochemical determination of trp in real food samples.

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“…The intense interest in nanotechnology is being driven by various interesting fields and is creating a new industrial revolution [18]. Nano-materials such as nanoparticles, carbon nanotubes or nanocomposite connected with biomolecules are being used for several bioanalytical applications [19][20][21]. Electroanalysis is taking advantage of all the possibilities offered by nanomaterials that are easy to detect using conventional electrochemical methods.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric determination of hydroxylamine in water and waste water samples using a NiO nanoparticle/new catechol derivative modified carbon paste electrode

Moazampour

Tahernejad-Javazmi

Salimi-Amiri

et al. 2014

J. Electrochem. Sci. Eng.

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Sensitive voltammetric determination of epinephrine in the presence of acetaminophen at a novel ionic liquid modified carbon nanotubes paste electrode

Cited by 201 publications

References 68 publications

Photoelectroanalytical Detection of Adrenaline Based on DNA and TiO2 Nanoparticles Sensitized with Bis(ethylenedithio)tetrathiafulvalene Exploiting LED Light

Photoelectroanalytical Detection of Adrenaline Based on DNA and TiO2 Nanoparticles Sensitized with Bis(ethylenedithio)tetrathiafulvalene Exploiting LED Light

Electrochemical determination of tryptophan at room-temperature ionic liquid-titanium carbide nanoparticle gel modified electrode

Voltammetric determination of hydroxylamine in water and waste water samples using a NiO nanoparticle/new catechol derivative modified carbon paste electrode

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