Sensitivity advantage of swept source and Fourier domain optical coherence tomography

Choma, Michael A.; Sarunic, Marinko V.; Yang, Changhuei; Izatt, Joseph A.

doi:10.1364/oe.11.002183

Cited by 1,659 publications

(976 citation statements)

References 15 publications

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“…The instrument is a high-speed UHR OCT system using spectral/Fourier domain detection. [34][35][36] Spectral/Fourier domain detection operates by first measuring the interference spectrum between backscattered or backreflected light from the tissue and light from a stationary reference arm. The magnitude and echo time delay of the light signal from the tissue is measured by taking the Fourier transform of this interference spectrum.…”

Section: Methodsmentioning

confidence: 99%

“…Broad-bandwidth superluminescent diode light sources, similar to the one used in this study, recently have been shown to enable UHR OCT image resolution performance approaching that of femtosecond lasers. [27][28][29][30][31][32][33][34][35][36][37][38] Our research prototype high-speed UHR OCT system has been described in detail in previous publications. [29][30][31][32][33] This system can acquire up to 25 000 axial scans per second, corresponding to ~49 images (512 axial scans per image) per second.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

et al. 2006

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Objective-To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies. Design-Retrospective cross-sectional study.Participants-Five hundred eighty-eight eyes of 327 patients with various macular pathologies.Methods-High-speed ultrahigh-resolution OCT images were obtained in 588 eyes of 327 patients with selected macular diseases. Ultrahigh-resolution OCT using Fourier/spectral domain detection achieves ~3-μm axial image resolutions, acquisition speeds of ~25 000 axial scans per second, and >3 times finer resolution and >50 times higher speed than standard OCT. Three scan protocols were investigated. The first acquires a small number of high-definition images through the fovea. The second acquires a raster series of high-transverse pixel density images. The third acquires 3-dimensional OCT data using a dense raster pattern. Three-dimensional OCT can generate OCT fundus images that enable precise registration of OCT images with the fundus. Using the OCT fundus images, OCT results were correlated with standard ophthalmoscopic examination techniques. Main Outcome Measures-High-definition macular pathologies.Results-Macular holes, age-related macular degeneration, epiretinal membranes, diabetic retinopathy, retinal dystrophies, central serous chorioretinopathy, and other pathologies were imaged and correlated with ophthalmic examination, standard OCT, fundus photography, and fluorescein angiography, where applicable. High-speed ultrahigh-resolution OCT generates images of retinal pathologies with improved quality, more comprehensive retinal coverage, and more precise registration than standard OCT. The speed preserves retinal topography, thus enabling the visualization of subtle changes associated with disease. High-definition high-transverse pixel density Conclusions-High-definition 3-dimensional imaging using high-speed ultrahigh-resolution OCT improves image quality, retinal coverage, and registration. This new technology has the potential to become a useful tool for elucidating disease pathogenesis and improving disease diagnosis and management.Optical coherence tomography (OCT) is a medical imaging technology that can perform highresolution cross-sectional imaging of tissue morphology in situ and in real time. Optical coherence tomography imaging is analogous to ultrasound, except that it uses light rather than sound and measures the echo time delay and magnitude of reflected or backscattered light using low-coherence interferometry. Cross-sectional images are generated by directing an optical beam onto tissue and scanning it in the transverse direction, thus yielding a data set that can be displayed as false-color or grayscale images. Despite the successful clinical application of OCT technology, there are several limitations. Without using techniques such as eye tracking, the total permissible image acquisition time is limited by subject eye motion, which can cause imag...

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

et al. 2006

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“…Since we are using a swept source setup, in addition to this analysis the sensitivity advantage of swept source setup must be added. Choma et al [20] have demonstrated that for a Gaussian source an increase is expected in sensitivity compared to δk are bandwidth and linewidth respectively of the light source in k-space. For our SS-OCT system this correspond to an increase of about 22 dB over the corresponding time domain OCT.…”

Section: Experimental Measurements and Discussionmentioning

confidence: 99%

“…The pioneering work in setting the stage for comparison between time domain OCT setups was reported by Rollins and Izatt [5] and Podoleanu [6]. As the interest in Fourier domain and swept source OCT has grown several groups independently proposed method to compare and translate the signal-to-noise results between time domain and Fourier domain systems [18][19][20].In this report we present an SNR analysis of our quadrature interferometric platform as integrated into a time domain system [5] followed by the correction proposed by Choma et al [20] to translate the SNR results for a SS-OCT.…”

Section: Signal To Noise Ratio Analysismentioning

confidence: 99%

Performance analysis of a swept-source optical coherence tomography system with a quadrature interferometer and optical amplification

Mao

Flueraru

Chang

et al. 2011

Optics Communications

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“…It is faster than the original optical coherence tomography technique (OCT), i.e. time domain optical coherence tomography (TDOCT), and has a sensitivity advantage [3][4][5]. Achieving ultrahigh resolution in OCT has been difficult to implement due to dispersion mismatch between sample and reference arm [6].…”

Section: Introductionmentioning

confidence: 99%

Common path Fourier domain optical coherence tomography based on multiple reflections within the sample arm

Krstajić

Hogg

Matcher

2011

Optics Communications

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We present a common path Fourier domain optical coherence tomography (FDOCT) setup where the reference signal arises from multiple reflections within the sample arm. Two configurations are demonstrated. The first is based on a reflective microscope objective while the second is based on a normal (refractive) microscope objective. The second configuration is effectively a Mireau interferometer. We present sensitivity analysis of these setups and images of in vivo skin. Advantages of both common path arrangements include: 1) the reference surface is not close to the sample surface while keeping the optical path lengths matched (so the additional interferometer is not needed) and 2) the user can independently control reference and sample arm power. Additionally, the configuration using the refractive objective ensures that the coherence gate and focus gate always match. A disadvantage is that the reference arm power in certain circumstances is not optimal (i.e. close to saturating the CCD). However, this issue can be removed by a light source of sufficient output power. We believe the idea is scalable and therefore of interest to endoscopy applications. 3 RESEARCH HIGHLIGHTS• Multiple reflections within the sample arm can be beneficial.• We demonstrate a novel common-path Fourier domain OCT based on Mireau interferometer.

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Sensitivity advantage of swept source and Fourier domain optical coherence tomography

Cited by 1,659 publications

References 15 publications

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

Performance analysis of a swept-source optical coherence tomography system with a quadrature interferometer and optical amplification

Common path Fourier domain optical coherence tomography based on multiple reflections within the sample arm

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