Sensitivity Analysis of a HIV Superinfection Model

Abstract

In this work, a HIV superinfection model with two unique viral strains was presented. The next generation method was adopted to compute the reproduction number of the model. The model was analyzed for the parameters responsible for the spread of the strains in the population of CD4 T-cells. This is to help us find the most sensitive parameters out of all. Using the normalized sensitivity index, the most sensitive parameter of the model is the rate of infection of the primary strain (β). Hence β should be minimized so that the population of the primary strains in the CD4 T cells population does not lead to an endemic state.