This study extracted 16 climatic data variables including annual temperature, freeze thaw, precipitation, and snow fall conditions from the Long-term Pavement Performance (LTPP) program database to evaluate the climatic regionalization for pavement infrastructure. The effect and significance of climate change were firstly evaluated using time as the only predictor and t-test. It was found that both the temperature and humidity increased in most States. Three unsupervised machine learning including Principle Component Analysis (PCA), factor analysis and cluster analysis were conducted to identify the main component and common factors for climatic variables, and then to classify datasets into different groups. Then, two supervised machine learning methods including Fisher’s discriminant analysis and Artificial Neural Networks (ANN) were adopted to predict the climatic regions based on climatic data. Results of PCA and factor analysis show that temperature and humidity are the first two principle components and common factors, accounting for 71.6% of the variance. The 4-means clusters include wet no freeze, dry no freeze, dry freeze and snow freeze. The best k-mean clustering suggested 9 clusters with more temperature clusters. Both the Fisher’s linear discriminant analysis and ANN can effectively predict climatic regions with multiple climatic variables. ANN performs better with higher R square and low misclassification rate, especially for those with more layers and nodes.