Due to geological processes such as sedimentation, tectonic movement, and backfilling, natural soil often exhibits characteristics of rotated anisotropy. Recent studies have shown the significant impact of rotated anisotropy on slope stability. However, little research has explored how this rotated anisotropy affects the large deformations occurring after slope failure. Therefore, this study integrates rotated random field theory with smoothed particle hydrodynamics (SPH) to investigate its influence on post‐failure slope behavior. Focusing on a typical slope scenario, this research utilizes graphics processing unit (GPU)–accelerated covariance matrix decomposition (CMD) method to create rotated anisotropy random fields and applies the SPH framework for analysis. It examines the influence of rotated anisotropy angles and the cross‐correlation between cohesion and internal friction angle on landslides. The results indicate that the rotational anisotropy of the slope significantly influences post‐failure behavior. When the rotation angle is close to the slope surface, it tends to amplify both the magnitude and variability of slope failure. Furthermore, the study evaluates the efficiency of generating these random fields and emphasizes the substantial computational speed improvements achieved with GPU acceleration. These findings offer a robust approach for probabilistic analysis of slope large deformations considering rotated anisotropy. They provide a theoretical foundation for accurately assessing the risk of slope collapse, holding significant practical implications for geotechnical engineering.