Sensitivity and reliability of cerebral oxygenation responses to postural changes measured with near-infrared spectroscopy

Mol, Arjen; Woltering, Jeffrey H. H.; Colier, Willy N.J.M.; Maier, Andrea B.; Meskers, Carel G.M.; Wezel, R.J.A. van

doi:10.1007/s00421-019-04101-0

Cited by 31 publications

(28 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…continuous monitoring of posture-related BP, BRS and CAR in patients with OH. Results on sensitivity and reliability of NIRS parameters in a subpopulation of this study (n = 15) were published before (Mol et al, 2019). Other previous research focused on specific aspects, such as PPG-based BP estimation (Chen et al, 2012;Sun et al, 2016), cerebral oxygenation changes during standing up (Mehagnoul-Schipper et al, 2000van Lieshout et al, 2001) and posture related PWV changes (Foo and Lim, 2006), but never assessed a combined ambulatory technique for BRS and CAR monitoring.…”

Section: Discussionmentioning

confidence: 99%

“…When combined with ECG, PPG can be used to compute pulse wave velocity (PWV), a parameter reflecting both BP, arterial stiffness and arterial vasoconstriction (Salvi, 2017). To assess CAR, cerebral oxygenation measured using NIRS may be used as a proxy for cerebral blood flow (Steiner et al, 2009;Kainerstorfer et al, 2015;Mol et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…The experimental protocol for both subgroups (adapted fromMol et al, 2019). The symbols on the y-axis indicate (from top to bottom): active standing, head-up tilt, sitting, supine, and squat position.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Multimodal Monitoring of Cardiovascular Responses to Postural Changes

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: In the poorly understood relationship between orthostatic hypotension and falls, next to blood pressure (BP), baroreflex sensitivity (BRS) and cerebral autoregulation (CAR) may be key measures. The posture-and movement dependency of orthostatic hypotension requires continuous and unobtrusive monitoring. This may be possible using simultaneous photoplethysmography (PPG), electrocardiography (ECG), and near-infrared spectroscopy (NIRS) signal recordings, from which pulse wave velocity (PWV; potentially useful for BP estimation), BRS and CAR can be derived. The PPG, NIRS and PWV signal correlation with BP and BRS/CAR reliability and validity need to be addressed. Methods: In 34 healthy adults (mean age 25 years, inter quartile range 22-45; 10 female), wrist and finger PPG, ECG, bifrontal NIRS (oxygenated and deoxygenated hemoglobin) and continuous BP were recorded during sit to stand and supine to stand movements. Sixteen participants performed slow and rapid supine to stand movements; eighteen other participants performed a 1-min squat movement. Pulse wave velocity (PWV) was defined as the inverse of the ECG R-peak to PPG pulse delay; PPG, NIRS and PWV signal correlation with BP as their Pearson correlations with mean arterial pressure (MAP) within 30 s after the postural changes; BRS as inter beat interval drop divided by systolic BP (SBP) drop during the postural changes; CAR as oxygenated hemoglobin drop divided by MAP drop. BRS and CAR were separately computed using measured and estimated (linear regression) BP. BRS/CAR reliability was defined by the intra class correlation between repeats of the same postural change; validity as the Pearson correlation between BRS/CAR values based on measured and estimated BP. Results: The highest correlation with MAP was found for finger PPG and oxygenated hemoglobin, ranging from 0.75-0.79 (sit to stand), 0.66-0.88 (supine to stand), and 0.82-0.94 (1-min squat). BRS and CAR reliability was highest during the different supine

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multimodal Monitoring of Cardiovascular Responses to Postural Changes

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…The study of the orthostatic response to standing from supine is of interest in older adults given its relationship with falls, depression and mortality (McCrory et al, 2016 ; Finucane et al, 2017 ; Briggs et al, 2019 ). Given the range in older adult mobility, the speed at which the transition is completed is an important source of variation that is associated with both timing and magnitude of hemeodynamic parameters (de Bruïne et al, 2017 ; Mol et al, 2019 ; O’Connor et al, 2020 ). The musculoskeletal effort of standing causes vasodilation in the lower limbs (as evidenced by larger changes during active vs. passive stand; van Wijnen et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…Whereas TCD measures the CBF in the basal arteries of the brain, near-infrared spectroscopy (NIRS) may be used to measure cerebral oxygenation levels (Colier et al, 1997 ; Mehagnoul-Schipper et al, 2000 ; Kawaguchi et al, 2001 ; Kim et al, 2018 ; Mol et al, 2019 ). Although sit-to-stand or supine-to-stand tests are suitable for older adults, the speed of postural transition is heterogeneous and the hemeodynamic response is influenced by standing speed (de Bruïne et al, 2017 ; Mol et al, 2019 ; O’Connor et al, 2020 ). This is not unexpected given that much of the physiological response to standing is driven by muscle activation in the lower limbs (van Wijnen et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Functional Analysis of Continuous, High-Resolution Measures in Aging Research: A Demonstration Using Cerebral Oxygenation Data From the Irish Longitudinal Study on Aging

O’Connor

O’Connell

Romero-Ortuño

et al. 2020

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Background: A shift towards the dynamic measurement of physiologic resilience and improved technology incorporated into experimental paradigms in aging research is producing high-resolution data. Identifying the most appropriate analysis method for this type of data is a challenge. In this work, the functional principal component analysis (fPCA) was employed to demonstrate a data-driven approach to the analysis of high-resolution data in aging research. Methods: Cerebral oxygenation during standing was measured in a large cohort [The Irish Longitudinal Study on Aging (TILDA)]. FPCA was performed on tissue saturation index (TSI) data. A regression analysis was then conducted with the functional principal component (fPC) scores as the explanatory variables and transition time as the response. Results: The mean ± SD age of the analysis sample was 64 ± 8 years. Females made up 54% of the sample and overall, 43% had tertiary education. The first PC explained 96% of the variance in cerebral oxygenation upon standing and was related to a baseline shift. Subsequent components described the recovery to before-stand levels (fPC2), drop magnitude and initial recovery (fPC3 and fPC4) as well as a temporal shift in the location of the minimum TSI value (fPC5). Transition time was associated with components describing the magnitude and timing of the nadir. Conclusions: Application of fPCA showed utility in reducing a large amount of data to a small number of parameters which summarize the inter-participant variation in TSI upon standing. A demonstration of principal component regression was provided to allow for continued use and development of data-driven approaches to high-resolution data analysis in aging research.

show abstract

Cerebral autoregulation assessed by near-infrared spectroscopy: validation using transcranial Doppler in patients with controlled hypertension, cognitive impairment and controls

et al. 2021

Self Cite

View full text Add to dashboard Cite

Purpose Cerebral autoregulation (CA) aims to attenuate the effects of blood pressure variation on cerebral blood flow. This study assessed the criterion validity of CA derived from near-infrared spectroscopy (NIRS) as an alternative for Transcranial Doppler (TCD). Methods Measurements of continuous blood pressure (BP), oxygenated hemoglobin (O2Hb) using NIRS and cerebral blood flow velocity (CBFV) using TCD (gold standard) were performed in 82 controls, 27 patients with hypertension and 94 cognitively impaired patients during supine rest (all individuals) and repeated sit to stand transitions (cognitively impaired patients). The BP-CBFV and BP-O2Hb transfer function phase shifts (TFφ) were computed as CA measures. Spearman correlations (ρ) and Bland Altman limits of agreement (BAloa) between NIRS- and TCD-derived CA measures were computed. BAloa separation < 50° was considered a high absolute agreement. Results NIRS- and TCD-derived CA estimates were significantly correlated during supine rest (ρ = 0.22–0.30, N = 111–120) and repeated sit-to-stand transitions (ρ = 0.46–0.61, N = 19–32). BAloa separation ranged between 87° and 112° (supine rest) and 65°–77° (repeated sit to stand transitions). Conclusion Criterion validity of NIRS-derived CA measures allows for comparison between groups but was insufficient for clinical application in individuals.

show abstract

Sensitivity and reliability of cerebral oxygenation responses to postural changes measured with near-infrared spectroscopy

Cited by 31 publications

References 39 publications

Multimodal Monitoring of Cardiovascular Responses to Postural Changes

Multimodal Monitoring of Cardiovascular Responses to Postural Changes

Functional Analysis of Continuous, High-Resolution Measures in Aging Research: A Demonstration Using Cerebral Oxygenation Data From the Irish Longitudinal Study on Aging

Cerebral autoregulation assessed by near-infrared spectroscopy: validation using transcranial Doppler in patients with controlled hypertension, cognitive impairment and controls

Contact Info

Product

Resources

About