Sensitivity and reliability of language laterality assessment with a free reversed association task—a fMRI study

Fesl, Gunther; Bruhns, P.; Rau, S.; Wiesmann, Martin; Ilmberger, J.; Kegel, Gerd; Brueckmann, Hartmut

doi:10.1007/s00330-009-1602-4

Cited by 22 publications

(33 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The test‐retest reproducibility of the adaptive semantic matching paradigm was good, with a mean Dice coefficient of similarity of 0.66 with our a priori analysis parameter set, and even higher Dice coefficients with other parameter sets. This compares favorably to all other reliability coefficients that have been reported for language mapping paradigms (Billingsley‐Marshall, Simos, & Papanicolaou, ; Brannen et al, ; Fernández et al, ; Fesl et al, ; Gross & Binder, ; Harrington et al, ; Maldjian et al, ; Rau et al, ; Rutten et al, ; see Wilson et al, for review); to our knowledge, the highest Dice coefficient previously reported for a paradigm with reasonable validity is 0.61 (Fesl et al, ), and participants in that study were neurologically normal. Other investigations of language mapping reliability in aphasia have used metrics such as the voxelwise intraclass correlation coefficients that do not provide an overall assessment of reliability (Eaton et al, ; Meltzer et al, ).…”

Section: Discussionsupporting

confidence: 83%

“…V overlap /(V 1 + V 2 ) where V overlap is the number of overlapping voxels, V 1 is the number of voxels activated in the first scan, and V 2 is the number of voxels activated in the second scan (Figure c). The advantages of the Dice coefficient are that it is easy to interpret (Bennett & Miller, ), is widely used (e.g., Fernández et al, ; Fesl et al, ; Gross & Binder, ; Harrington et al, ; Rutten et al, ), can be calculated in any individual without reference to a group (Bennett & Miller, ); and yields a single metric of overall activation similarity encompassing all brain regions under consideration (Wilson et al, ). In these last two respects, the Dice coefficient is more useful than the intraclass correlation coefficient, another metric sometimes used in research on language mapping paradigms (Fernández et al, ; Eaton et al, ; Meltzer et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…In the control condition, participants make perceptual decisions about sequences of high and low tones (deciding whether exactly two high tones occurred). Semantic decision paradigms show good test‐retest reproducibility (Fernández et al, ; Fesl et al, ), probably due to the highly constrained processing involved in both the language and control tasks. Moreover, the deep, active, challenging language processing engendered by semantic tasks reliably activates strongly lateralized frontal and temporal language regions in people without language deficits, providing evidence for validity (Binder et al, ; Fesl et al, ; Janecek et al, ; Springer et al, ; Szaflarski et al, ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An adaptive semantic matching paradigm for reliable and valid language mapping in individuals with aphasia

Wilson

Yen

Eriksson

2018

Human Brain Mapping

View full text Add to dashboard Cite

Research on neuroplasticity in recovery from aphasia depends on the ability to identify language areas of the brain in individuals with aphasia. However, tasks commonly used to engage language processing in people with aphasia, such as narrative comprehension and picture naming, are limited in terms of reliability (test-retest reproducibility) and validity (identification of language regions, and not other regions). On the other hand, paradigms such as semantic decision that are effective in identifying language regions in people without aphasia can be prohibitively challenging for people with aphasia. This paper describes a new semantic matching paradigm that uses an adaptive staircase procedure to present individuals with stimuli that are challenging yet within their competence, so that language processing can be fully engaged in people with and without language impairments. The feasibility, reliability and validity of the adaptive semantic matching paradigm were investigated in sixteen individuals with chronic post-stroke aphasia and fourteen neurologically normal participants, in comparison to narrative comprehension and picture naming paradigms. All participants succeeded in learning and performing the semantic paradigm. Test-retest reproducibility of the semantic paradigm in people with aphasia was good (Dice coefficient = 0.66), and was superior to the other two paradigms. The semantic paradigm revealed known features of typical language organization (lateralization; frontal and temporal regions) more consistently in neurologically normal individuals than the other two paradigms, constituting evidence for validity. In sum, the adaptive semantic matching paradigm is a feasible, reliable and valid method for mapping language regions in people with aphasia.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An adaptive semantic matching paradigm for reliable and valid language mapping in individuals with aphasia

Wilson

Yen

Eriksson

2018

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…They advocated plotting the LI as a function of the number of active voxels, similar to threshold dependent curves; these curves are however tighter and more stable. Furthermore, Fesl et al (2010) reported improved reliability of LI measurement when using this variable threshold method as opposed to a single fixed threshold. However, this approach does not remove the need for arbitrary decisions, since a ‘reasonable’ fixed number of active voxels must be decided on.…”

Section: Resultsmentioning

confidence: 97%

“…One such method involves choosing that threshold which yields a fixed number of active voxels for each individual participant (Knecht et al, 2003; Jansen et al, 2006; Abbott et al, 2010; Fesl et al, 2010). Using simulated data, Abbott et al (2010) demonstrated that thresholding at a fixed number of voxels was more robust against variability in signal strength than the standard thresholding method.…”

Section: Resultsmentioning

confidence: 99%

Methodological considerations in assessment of language lateralisation with fMRI: a systematic review

Bradshaw

Bishop

Woodhead

2017

PeerJ

View full text Add to dashboard Cite

The involvement of the right and left hemispheres in mediating language functions has been measured in a variety of ways over the centuries since the relative dominance of the left hemisphere was first known. Functional magnetic resonance imaging (fMRI) presents a useful non-invasive method of assessing lateralisation that is being increasingly used in clinical practice and research. However, the methods used in the fMRI laterality literature currently are highly variable, making systematic comparisons across studies difficult. Here we consider the different methods of quantifying and classifying laterality that have been used in fMRI studies since 2000, with the aim of determining which give the most robust and reliable measurement. Recommendations are made with a view to informing future research to increase standardisation in fMRI laterality protocols. In particular, the findings reinforce the importance of threshold-independent methods for calculating laterality indices, and the benefits of assessing heterogeneity of language laterality across multiple regions of interest and tasks. This systematic review was registered as a protocol on Open Science Framework: https://osf.io/hyvc4/.

show abstract

Repeatability of language fMRI lateralization and localization metrics in brain tumor patients

Agarwal

Hua

Sair

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

To assess the within-subject intra-scan session repeatability of language functional MRI (fMRI) activation maps in patients with brain tumors who were undergoing presurgical fMRI as part of their preoperative clinical workup. Sentence completion (SC) and silent word generation (SWG) tasks were used for language localization and hemispheric lateralization for identifying the primary language cortex. Within-subject repeatability for each of these paradigms was assessed in right-handed patients—37 for SC and 78 for SWG. Repeatability of activation maps between consecutive runs of the same task within the same scan session was evaluated by comparing lateralization indexes in holohemispheric and regional language areas. Displacement of center of activation between consecutive runs was also used to assess the repeatability of activation maps. Holohemispheric and regional language lateralization results demonstrated high intrasubject intra-scan repeatability when lateralization indices were calculated using thresholddependent and threshold-independent approaches. The high repeatability is demonstrated both when centers of mass of activation are considered within key eloquent regions of the brain, such as Broca’s area and Wernicke’s area, as well as in larger more inclusive expressive and receptive language regions. We examined two well-known and widely accepted language tasks that are known to activate eloquent language cortex. We have demonstrated very high degree of repeatability at a single-subject level within single scan sessions of language mapping in a large cohort of brain tumor patients undergoing presurgical fMRI across several years at our institution.

show abstract

Sensitivity and reliability of language laterality assessment with a free reversed association task—a fMRI study

Abstract: 'Free reversed association' is a sensitive and reliable task for the determination of individual language lateralization. This suggests that the task may be used in a clinical setting.

Cited by 22 publications

References 53 publications

An adaptive semantic matching paradigm for reliable and valid language mapping in individuals with aphasia

An adaptive semantic matching paradigm for reliable and valid language mapping in individuals with aphasia

Methodological considerations in assessment of language lateralisation with fMRI: a systematic review

Repeatability of language fMRI lateralization and localization metrics in brain tumor patients

Contact Info

Product

Resources

About