Sensitivity and reliability of zinc transporter and metallothionein gene expression in peripheral blood mononuclear cells as indicators of zinc status: responses to<i>ex vivo</i>zinc exposure and habitual zinc intake in humans

Hennigar, Stephen R.; Kelley, Alyssa M.; Anderson, Bradley J.; Armstrong, Nicholes J.; McClung, Holly L.; Berryman, Claire E.; Karl, J Philip; McClung, James P.

doi:10.1017/s0007114520002810

Cited by 19 publications

(10 citation statements)

References 48 publications

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“…It should be noted that in the periods leading up to biopsy collection as part of this study, both groups of children received nutritional supplements, including zinc. Whether this might explain the differential expression of metallothioneins is not clear, as metallothionein expression in blood cells can be modulated by zinc exposure in vivo and in vitro [43] . Further work is required on the impact of zinc on intestinal expression of genes involved in zinc absorption.…”

Section: Discussionmentioning

confidence: 99%

Gene expression profiles compared in environmental and malnutrition enteropathy in Zambian children and adults

et al. 2021

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Background: Environmental enteropathy (EE) contributes to growth failure in millions of children worldwide, but its relationship to clinical malnutrition has not been elucidated. We used RNA sequencing to compare duodenal biopsies from adults and children with EE, and from children with severe acute malnutrition (SAM), to define key features of these malnutrition-related enteropathies. Methods: RNA was extracted and sequenced from biopsies of children with SAM in hospital ( n =27), children with non-responsive stunting in the community ( n =30), and adults living in the same community ( n =37) using an identical sequencing and analysis pipeline. Two biopsies each were profiled and differentially expressed genes (DEGs) were computed from the comparisons of the three groups. DEG lists from these comparisons were then subjected to analysis with CompBio software to assemble a holistic view of the biological landscape and IPA software to interrogate canonical pathways. Findings: Dysregulation was identified in goblet cell/mucin production and xenobiotic metabolism/detoxification for both cohorts of children, versus adults. Within the SAM cohort, substantially greater induction of immune response and barrier function, including NADPH oxidases was noted, concordant with broadly reduced expression of genes associated with the brush border and intestinal structure/transport/absorption. Interestingly, down regulation of genes associated with the hypothalamic-pituitary-adrenal axis was selectively observed within the cohort of children with stunting. Interpretation: Gene expression profiles in environmental enteropathy and severe acute malnutrition have similarities, but SAM has several distinct transcriptional features. The intestinal capacity to metabolise drugs and toxins in malnourished children requires further study. Funding: Bill & Melinda Gates Foundation (OPP1066118)

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Section: Discussionmentioning

confidence: 99%

Gene expression profiles compared in environmental and malnutrition enteropathy in Zambian children and adults

et al. 2021

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“…A pain state is usually associated with inflammation, and zinc is a metallothionein with anti-inflammatory properties. Those properties are suggested to be responsible for the therapeutic benefit of zinc [ 115 ]. The efficacy of zinc in reducing pain has been assessed in a variety of animal models.…”

Section: Nutritional Supplements In Neuropathic Painmentioning

confidence: 99%

The Influence of Dietary Supplementations on Neuropathic Pain

D’Egidio

Lombardozzi

M’Barek

et al. 2022

Life

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Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system and affects 7–10% of the worldwide population. Neuropathic pain can be induced by the use of drugs, including taxanes, thus triggering chemotherapy-induced neuropathic pain or as consequence of metabolic disorders such as diabetes. Neuropathic pain is most often a chronic condition, and can be associated with anxiety and depression; thus, it negatively impacts quality of life. Several pharmacologic approaches exist; however, they can lead numerous adverse effects. From this perspective, the use of nutraceuticals and diet supplements can be helpful in relieve neuropathic pain and related symptoms. In this review, we discuss how diet can radically affect peripheral neuropathy, and we focus on the potential approaches to ameliorate this condition, such as the use of numerous nutritional supplements or probiotics.

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“…The therapeutic benefit of zinc in the treatment of pain is attributed to its antiinflammatory properties as a metallothionein [38,39], which is important because inflammation is a driver of chronic pain states including neuropathic pain [40,41]. Zinc has been demonstrated to reduce pain in a number of preclinical models, first in rats, likely due to these anti-inflammatory properties.…”

Section: Zinc For Neuropathic Painmentioning

confidence: 99%

Nutritional Supplements for the Treatment of Neuropathic Pain

Abdelrahman

Hackshaw

2021

Biomedicines

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Neuropathic pain affects 7–10% of the population and is often ineffectively and incompletely treated. Although the gold standard for treatment of neuropathic pain includes tricyclic antidepressants (TCAs), serotonin-noradrenaline reuptake inhibitors, and anticonvulsants, patients suffering from neuropathic pain are increasingly turning to nonpharmacologic treatments, including nutritional supplements for analgesia. So-called “nutraceuticals” have garnered significant interest among patients seeking to self-treat their neuropathic pain with readily available supplements. The supplements most often used by patients include vitamins such as vitamin B and vitamin D, trace minerals zinc and magnesium, and herbal remedies such as curcumin and St. John’s Wort. However, evidence surrounding the efficacy and mechanisms of these supplements in neuropathic pain is limited, and the scientific literature consists primarily of preclinical animal models, case studies, and small randomized controlled trials (RCTs). Further exploration into large randomized controlled trials is needed to fully inform patients and physicians on the utility of these supplements in neuropathic pain. In this review, we explore the basis behind using several nutritional supplements commonly used by patients with neuropathic pain seen in rheumatology clinics.

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Sensitivity and reliability of zinc transporter and metallothionein gene expression in peripheral blood mononuclear cells as indicators of zinc status: responses toex vivozinc exposure and habitual zinc intake in humans

Cited by 19 publications

References 48 publications

Gene expression profiles compared in environmental and malnutrition enteropathy in Zambian children and adults

Gene expression profiles compared in environmental and malnutrition enteropathy in Zambian children and adults

The Influence of Dietary Supplementations on Neuropathic Pain

Nutritional Supplements for the Treatment of Neuropathic Pain

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