Sensitivity and Selectivity of Porous Electrodes in Heterogeneous Liquid-Based Catalytic Reactions: 3D Simulation Study

Halhouli, Mohammad; Kieninger, Jochen; Daubinger, Patrick; Yurchenko, Olena; Urban, G.

doi:10.1149/2.0151610jes

Cited by 3 publications

(2 citation statements)

References 73 publications

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“…In this work, it was shown that only 10-15% of the total quantity of adsorbed enzymes contributed to the catalysis. Further, simulation studies have been performed for a rational design of 3D porous electrodes with enhanced selectivity and sensitivity (Halhouli et al, 2016). In this case, not only the size but also the number of pores influence the diffusion within the electrode due to an enhanced diffusion resistance.…”

Section: Unmet Needs and Future Perspectivesmentioning

confidence: 99%

3D biosensors in advanced medical diagnostics of high mortality diseases

Rebelo

Barbosa

Caballero

et al. 2019

Biosensors and Bioelectronics

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Cardiovascular diseases, cancer, and diabetes are high mortality diseases, which account for almost two thirds of all deaths worldwide. Their early detection and continuous evaluation are fundamental for an improved patient prognosis and reduced socioeconomic impact. Current biosensor technologies are typically based on the analysis of whole blood samples from patients for the detection of disease-specific biomarkers. However, these technologies display serious shortcomings, such as reduced sensitivity and dynamic range, limited in vivo applicability, and lack of continuous monitoring. There is the urgent need for new diagnostic and treatment follow-up tools, which allow for the early detection of the pathology as well as for the continuous monitoring of the physiological responses to specific therapies. During the last years, a new generation of biosensor technologies with improved performance has emerged in the biomedical sector. The combination of advanced biomaterial methods, biochemical tools, and micro/nanotechnology approaches has resulted in the development of innovative three-dimensional (3D) biosensor platforms for advanced medical diagnosis. In this review, we report the most recent advances in the field of 3D biosensors for clinical applications, focusing on the diagnosis and monitoring of cardiovascular diseases, cancer, and diabetes. We discuss about their clinical performance compared to standard biosensor technologies, their implantable capability, and their integration into microfluidic devices to develop clinically-relevant models. Overall, we anticipate that 3D biosensors will drive us toward a new paradigm in medical diagnosis, resulting in real-time in vivo biosensors capable to significantly improve patient prognosis.

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Section: Unmet Needs and Future Perspectivesmentioning

confidence: 99%

3D biosensors in advanced medical diagnostics of high mortality diseases

Rebelo

Barbosa

Caballero

et al. 2019

Biosensors and Bioelectronics

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“…Previously, we discussed the morphological characteristics that lead to an increase in the catalytic efficiency, the selectivity, and the sensitivity of nonhierarchical porous layers . The aim of this study is to provide a deep understanding of the role of the surface morphological aspects, such as the roughness factor, porosity, and macropore size, in the catalytic activity of hierarchical porous layers.…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Morphological Characteristics to Determine the Optimal Hierarchical Nanostructures in Heterogeneous Catalysis

et al. 2016

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This work draws attention to the optimal hierarchical nanostructure morphology and the morphological characteristics that lead to a rational design of heterogeneous nanocatalysts, especially for reactions that exhibit sluggish kinetics. A simplified methanol oxidation on two types of hierarchical nanostructures, external and internal, is reported. A complex system of asymmetric geometries was simplified by mapping 3 D geometries into 2 D models by using a mass transport approach. The macropore size was the most comprehensive characteristic to evaluate the specific activity and current density of hierarchical nanostructures. The optimal current densities for both types of nanostructures were achieved in macropore size ranges of 3.2–4.5 and 1.9–3.2 μm, respectively. The optimal mass activity of the internal nanostructures was achieved in the porosity range of 40–50 %, whereas that of the external hierarchical nanostructures was achieved at high porosity values. In comparison to internal hierarchical nanostructures, external hierarchical nanostructures tend to be cost‐effective catalysts that have a high catalytic activity.

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Platinum nanowires anchored on graphene-supported platinum nanoparticles as a highly active electrocatalyst towards glucose oxidation for fuel cell applications

et al. 2017

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The limited performance of platinum-based electrocatalysts for glucose electrooxidation is a major concern for glucose fuel cells, since glucose electrooxidation is characterized by slow reaction kinetics and low diffusion coefficient. Here, the presented graphene-supported platinum-based hierarchical nanostructures attain highly enhanced electrocatalytic activity towards glucose oxidation. Platinum nanoparticles electrodeposited on graphene support retain mechanical stability and act as junctions allowing a reliable, smooth and dense growth of platinum nanowires with extremely small diameters (>10 nm) on graphene. The electrode's surface roughness was increased by factors up to 4000 to the geometrical surface area enabling maximized exploitation of the electrocatalytic activity of platinum and efficient electron transfer between nanowires and the substrate. The unique three-dimensional geometry of these hierarchical nanostructures has a significant impact on their catalytic performance offering short diffusional paths for slow glucose species, thus, mass transport limitations are optimized leading to lower polarization losses. This was examined by galvanostatic measurements of the operation as anodes in glucose half-cells under conditions corresponding to implantable glucose fuel cells. The presented hierarchical nanostructures show remarkably enhanced catalytic performance for glucose electrooxidation, i.e. a negatively shifted open circuit potential of -580 mV vs. Ag/AgCl, hence, representing appropriate electrocatalysts for use as anodes in glucose fuel cells. In combination with a non-metal N-doped graphene cathode, a cell potential of 0.65 V was achieved at a galvanostatic load of 17.5 μA cm which noticeably surpasses the performance of state of the art catalysts for the aforementioned operation conditions.

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Sensitivity and Selectivity of Porous Electrodes in Heterogeneous Liquid-Based Catalytic Reactions: 3D Simulation Study

Cited by 3 publications

References 73 publications

3D biosensors in advanced medical diagnostics of high mortality diseases

3D biosensors in advanced medical diagnostics of high mortality diseases

Rational Design of Morphological Characteristics to Determine the Optimal Hierarchical Nanostructures in Heterogeneous Catalysis

Platinum nanowires anchored on graphene-supported platinum nanoparticles as a highly active electrocatalyst towards glucose oxidation for fuel cell applications

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