Numerous terms, including repetitive-stress injuries and cumulative-trauma disorders, have been used to describe what is now commonly termed work-related musculoskeletal disorders. The etiology of work-related musculoskeletal disorders is multifactorial and includes physical, individual, and psychosocial factors that contribute to the presenting symptoms. Prolonged positioning away from the ideal posture will affect neural and other soft tissues in the upper extremity. Abnormal postures and positions may result in chronic nerve compression or may shorten muscles and, if the muscle crosses over a nerve, compression may occur. These postures may also contribute to muscle imbalance. A thorough clinical evaluation is necessary to identify all sites of nerve compression, muscle imbalance, and factors affecting patient symptoms so that appropriate intervention can be instituted. Management must include patient education, postural correction, and a specific physical therapy program to address the multiple levels of nerve compression and cervicoscapular muscle imbalance. In addition to physical therapy intervention, behavioral modification at home and at work may be necessary for successful management. J Orthop Sports Phys Ther 2004;34:628-637.