Sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignancies

Alam, Shahid; Tongbram, Andrea; Krishnakumar, Subramanian; Biswas, Jyotirmay; Mukherjee, Bipasha

doi:10.4103/ijo.ijo_2096_18

Cited by 11 publications

(3 citation statements)

References 29 publications

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“…A recent study shows that while the frozen section closely approximates the results of the permanent section, the sensitivity of the permanent section is better than that of the frozen section in SGC. [ 22 ] There is also data to show that delayed reconstruction after paraffin section margin clearance gives good results. [ 23 ] However, wherever the facility is available, a single-stage procedure with on-table frozen section margin clearance and reconstruction would be preferable.…”

Section: Discussionmentioning

confidence: 99%

Malignant tumors of the eyelid in India: A multicenter, multizone study on clinicopathologic features and outcomes

Gupta

Bhaduri

Desai

et al. 2020

Indian J Ophthalmol

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Section: Discussionmentioning

confidence: 99%

Malignant tumors of the eyelid in India: A multicenter, multizone study on clinicopathologic features and outcomes

Gupta

Bhaduri

Desai

et al. 2020

Indian J Ophthalmol

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“…evaluated the value of frozen section in diagnosing orbital and adnexal malignancies. [ 29 ] Frozen section was found to be 100% specific and sensitive in cases of basal cell carcinoma with equal specificity (100%) but less sensitivity to SGC (83.3%). They stressed on the fact that it should not be used as a complete alternative for permanent sections.…”

Section: Introductionmentioning

confidence: 99%

“…They stressed on the fact that it should not be used as a complete alternative for permanent sections. [ 29 ]…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review of biopsy techniques for oculoplastic and orbital surgeons from ophthalmic pathologists’ perspective

Alkatan

Alyousef

Alshabib

et al. 2021

Saudi Journal of Ophthalmology

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This narrative review aims to discuss different modalities for obtaining diagnostic orbital biopsies, compares the available updated methods, and provides recommendations on the choice of technique. It also highlights special precautions in the handling of orbital specimens from various pathologies. A search was performed in PubMed and Google Scholar with no language or study type restriction. The keywords orbital biopsy, core biopsy, fine-needle aspiration biopsy, and orbit were used, and titles and abstracts were screened for relevance.

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Neoplasms of the Eye and Orbit

Alvarez¹,

Ponce²,

Chevez‐Barrios³

et al. 2022

Holland‐Frei Cancer Medicine

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Overview Cancers of the eye and orbit are associated with diverse pathological conditions, disease prognosis, and significant mortality. The survival rates vary among patients from different countries and have been reported to be significantly lower in those from developing countries compared to those noted in the United States owing mainly to delay in diagnosis associated with advanced‐stage disease and unavailability of treatments. In this article, we provide an overview of the most common and rare ophthalmic malignancies that include ocular surface, external and adnexal diseases, and orbital and intraocular malignancies. We summarize the incidence, histopathology, risk factors, molecular alterations, clinical presentation, diagnostic evaluation, and therapeutic approaches for these diseases. We also describe the first‐line and salvage treatments and their complications. These treatments depend on disease stage at presentation and include pathology‐guided excision, Mohs microsurgery, chemo‐reduction, chemoprophylaxis, adjuvant chemotherapy after enucleation, and/or neoadjuvant chemotherapy. Complications include symblepharon, scarring, and limbal stem cell deficiency while incomplete excision of eyelid tumors may result in recurrence of larger and more aggressive tumors. Currently, identification of genetic abnormalities identified in genomic profiling of patient tumors improves treatment selection. Early diagnosis and involvement of an ocular oncologist at the time of diagnosis will optimize the therapeutic management of patients with these diseases.

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Sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignancies

Cited by 11 publications

References 29 publications

Malignant tumors of the eyelid in India: A multicenter, multizone study on clinicopathologic features and outcomes

Malignant tumors of the eyelid in India: A multicenter, multizone study on clinicopathologic features and outcomes

A comprehensive review of biopsy techniques for oculoplastic and orbital surgeons from ophthalmic pathologists’ perspective

Neoplasms of the Eye and Orbit

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