Sensitivity and Specificity of the AdenoPlus Test for Diagnosing Adenoviral Conjunctivitis

Sambursky, Robert; Trattler, William; Tauber, Shachar; Starr, Chauncey; Friedberg, Murray; Boland, Thomas; McDonald, Marguerite B.; DellaVecchia, Michael A.; Luchs, Jodi

doi:10.1001/2013.jamaophthalmol.513

Cited by 56 publications

(34 citation statements)

References 36 publications

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“…2 We are aware of 3 diagnostic accuracy studies of the AdenoPlus point-of-care test. The study we cited in our editorial 3 found a sensitivity of 39.5% in a hospital eye emergency department, Sambursky et al 4 found a much higher sensitivity of 85% to 90% (depending on the reference standard used) in ophthalmology private practices and academic centers, whereas Holtz et al 5 found a sensitivity of 50% in acute eye care clinics. There are several reasons why diagnostic accuracy studies find differences in accuracy, including the population studied, prevalence of disease, as well as issues that may affect internal validity of a diagnostic accuracy estimate such as study design.…”

mentioning

confidence: 87%

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Keen

Thompson

2018

Ophthalmology

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mentioning

confidence: 87%

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Keen

Thompson

2018

Ophthalmology

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“…1,2 HSV can also cause EKC, which is difficult to distinguish clinically from adenoviral conjunctivitis. 28 Active chicken pox and prior exposure to chicken pox or shingles are predisposing factors for VZV conjunctivitis. 1 This condition is commonly unilateral in presentation.…”

Section: Viral Conjunctivitismentioning

confidence: 99%

<p>A Review of the Differential Diagnosis of Acute Infectious Conjunctivitis: Implications for Treatment and Management</p>

Yeu¹,

Hauswirth²

2020

OPTH

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The diagnosis of acute infectious conjunctivitis can be difficult. Clinical ambiguity exists between the acute viral and bacterial as well as the allergic forms, which can confound diagnosis. Also, discrimination between viral or bacterial origins of infectious conjunctivitis based on historical, nonspecific, clinical signs and symptoms contributes to a high rate of misdiagnosis and overuse of antibiotic treatment. Therefore, in order to effectively treat acute infectious conjunctivitis, physicians must be aware of the clinical signs and symptoms and available diagnostic tests that can provide a more accurate differential diagnosis.

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“…Shell vial culture (taking a few days) and Adenoclone are far less common diagnostic methods. A second-generation point-of-care diagnostic immunoassay that can detect the virus hexon antigen is available [44]. The result of the AdenoPlus (Quidel, San Diego, CA) returns quickly; though specificity is high, sensitivity can range widely [45,46].…”

Section: Types Of Adenoviral Ocular Infections Diagnosis and Antibimentioning

confidence: 99%

Adenoviral Keratoconjunctivitis: Diagnosis, Management, and Prevention

Kuo

2019

Curr Ophthalmol Rep

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Purpose of Review This review will provide an updated overview of the diagnosis, management, and prevention of adenoviral keratoconjunctivitis. Recent Findings Human adenovirus (HAdV) is undergoing nomenclature changes because of whole genome sequencing. Recombination has led to newly identified ocular pathogens like HAdV-D53, HAdV-D54, and HAdV-D56. No quick, highly sensitive and specific diagnostic test is available for ocular adenoviral infections. PCR takes a few hours but is not widely available. Results of using PCR in employees at one medical center support the view of endemic HAdV in the community. Summary Infection control is highly important as no treatment for ocular HAdV infections exists, ocular sequelae can be significant, and HAdV is endemic. Diagnosis of HAdVocular infections can be challenging; ophthalmologists are best positioned to diagnose the condition and provide antibiotic stewardship. Development of an accurate diagnostic test with quick turnaround would lead to major benefits in terms of less antibiotic use and fewer work furloughs. Outbreaks occur when infection control becomes lax.

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Sensitivity and Specificity of the AdenoPlus Test for Diagnosing Adenoviral Conjunctivitis

Cited by 56 publications

References 36 publications

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<p>A Review of the Differential Diagnosis of Acute Infectious Conjunctivitis: Implications for Treatment and Management</p>

Adenoviral Keratoconjunctivitis: Diagnosis, Management, and Prevention

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