Sensitivity and Specificity of the Pap Smear for Glandular Lesions of the Cervix and Endometrium

Geldenhuys, Laurette; Murray, Michelle L.

doi:10.1159/000325682

Cited by 26 publications

(18 citation statements)

References 28 publications

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“…The Pap smear is the most effective cancer prevention (Geldenhuys et al, 2007). In the countries where it is performed, the morbidity and mortality rates of the cervical cancer showed a substantial decrease.…”

Section: Introductionmentioning

confidence: 99%

Knowledge about Cervical Cancer Risk Factors and Pap Smear Testing Behavior among Female Primary Health Care Workers: A Study from South Turkey

Coskun¹,

Can²,

Turan³

2013

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 99%

Knowledge about Cervical Cancer Risk Factors and Pap Smear Testing Behavior among Female Primary Health Care Workers: A Study from South Turkey

Coskun¹,

Can²,

Turan³

2013

Asian Pacific Journal of Cancer Prevention

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“…This situation is more dangerous and feared, since follow-up methods are unreliable for endocervical glandular lesions; colposcopy is a blind method for these lesions and data on the reliability of the HPV test in the followup of invasive glandular disease [16] are not enough. Pap smear is not considered to be a reliable method for the followup of glandular lesions, even if data show a good sensitivity of cervical cytology even for MIAC [17]. Another concern may be the difficulty to exactly stage the microinvasive glandular lesions.…”

Section: Discussionmentioning

confidence: 99%

Conservative Treatment of Stage IA1 Adenocarcinoma of the Uterine Cervix during Pregnancy: Case Report and Review of the Literature

Sopracordevole

Rossi

Giuseppe

et al. 2014

Case Reports in Obstetrics and Gynecology

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Microinvasive adenocarcinoma (MIAC) of the uterine cervix is rare in pregnancy. Published data on conservative treatment of MIAC both in pregnant and nonpregnant women are scarce. A conservatively treated case of MIAC in a 13-week-pregnant woman after a diagnosis of atypical glandular cells (AGC) on pap smear at the 6th week of pregnancy is presented. The problems of suspected adenocarcinoma in situ (AIS) on biopsy and MIAC on cone biopsy in pregnancy, as well as the risks and benefits of a conservative treatment are discussed. After colposcopic guide laser cervical conization and expression of informed consent the patient underwent followup and vaginal delivery at 40 weeks plus 3 days of gestation. In this case, no obstetric complication has been recorded after the cervical conization, and after a followup of 18 months the patient was alive and free of disease, with negative results as far as pap smear, colposcopy, HPV status, and cervical curettage are concerned. In a stage Ia1 disease of endocervical type, with clear margins and without lymph-vascular space invasion, cervical conization performed during the second trimester may be considered a definitive and safe treatment, at least up to delivery, after expression of informed consent by the woman.

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“…The Papanicolaou (Pap) test is currently the main screening method for cervical precancerous changes and CC (13,14). However, the sensitivity of the Pap test varies greatly, ranging between 30-87%, and sometimes being as low as 20% (14,15).…”

Section: Introductionmentioning

confidence: 99%

“…However, the sensitivity of the Pap test varies greatly, ranging between 30-87%, and sometimes being as low as 20% (14,15). In addition, the infrastructure used for Pap screening is expensive and is difficult to implement in developing countries (16).…”

Section: Introductionmentioning

confidence: 99%

Quantitative DNA methylation analysis of paired box gene 1 and LIM homeobox transcription factor 1 α genes in cervical cancer

et al. 2018

Oncol Lett

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Abstract. DNA methylation is associated with tumorigenesis and may act as a potential biomarker for detecting cervical cancer. The aim of the present study was to explore the methylation status of the paired box gene 1 (PAX1) and the LIM homeobox transcription factor 1 α (LMX1A) gene in a spectrum of cervical lesions in an Eastern Chinese population. This single-center study involved 121 patients who were divided into normal cervix (NC; n=28), low-grade squamous intraepithelial lesion (LSIL; n=32), high-grade squamous intraepithelial lesion (HSIL; n=34) and cervical squamous cell carcinoma (CSCC; n=27) groups, according to biopsy results. Following extraction and modification of the DNA, quantitative assessment of the PAX1 and LMX1A genes in exfoliated cells was performed using pyrosequencing analysis. Receiver operating characteristic (ROC) curves were generated to calculate the sensitivity and specificity of each parameter and cut-off values of the percentage of methylation reference (PMR) for differentiation diagnosis. Analysis of variance was used to identify differences among groups. The PMR of the two genes was significantly higher in the HSIL and CSCC groups compared with that in the NC and LSIL groups (P<0.001). ROC curve analysis demonstrated that the sensitivity, specificity and accuracy for detection of CSCC were 0.790, 0.837 and 0.809, respectively, using PAX1; and 0.633, 0.357 and 0.893, respectively, using LMX1A. These results indicated that quantitative PAX1 methylation demonstrates potential for cervical cancer screening, while further investigation is required to determine the potential of LMX1A methylation.

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Sensitivity and Specificity of the Pap Smear for Glandular Lesions of the Cervix and Endometrium

Cited by 26 publications

References 28 publications

Knowledge about Cervical Cancer Risk Factors and Pap Smear Testing Behavior among Female Primary Health Care Workers: A Study from South Turkey

Knowledge about Cervical Cancer Risk Factors and Pap Smear Testing Behavior among Female Primary Health Care Workers: A Study from South Turkey

Conservative Treatment of Stage IA1 Adenocarcinoma of the Uterine Cervix during Pregnancy: Case Report and Review of the Literature

Quantitative DNA methylation analysis of paired box gene 1 and LIM homeobox transcription factor 1 α genes in cervical cancer

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