Sensitivity and Specificity of Two Investigational Point of Care Tests for Syphilis and HIV (PoSH Study) for the Diagnosis and Treatment of Infectious Syphilis in Canada: A Cross Sectional Study

Singh, Ameeta E.; Ives, Noel; Gratrix, Jennifer; Vetland, Carla; Ferron, Leslie; Crawford, Megan; Hale-Balla, Lisa; Dong, Kathryn; Meyer, Garret; Smyczek, Petra; Galli, Rick; Rourke, Sean B.; Fonseca, Kevin; Team, PoSH Study

doi:10.2139/ssrn.4289474

Cited by 2 publications

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“…Recent trials of one such test have shown good sensitivity for cases with RPR ≥8 dilutions, which would have included all our cases. 16,17 One must also keep in mind the motto "Treatment is prevention." Improved diagnosis and treatment of syphilis before pregnancy and of sexual partners will decrease the incidence of syphilis in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…A further innovative practice would be to incorporate a syphilis point-of-care test in conjunction with outreach services, allowing persons to be diagnosed and treated at the same visit, while reducing barriers to accessing care. Recent trials of one such test have shown good sensitivity for cases with RPR ≥8 dilutions, which would have included all our cases 16,17 . One must also keep in mind the motto “Treatment is prevention.” Improved diagnosis and treatment of syphilis before pregnancy and of sexual partners will decrease the incidence of syphilis in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

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Case series of stillbirths due to syphilis in Edmonton, Alberta, Canada

et al. 2023

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Background Data on the incidence and characteristics of stillbirths attributed to congenital syphilis were collected. Methods We extracted data on stillbirths in the Edmonton Zone on January 1, 2015, through June 30, 2021, born to persons diagnosed with infectious syphilis (primary, secondary, early latent, or early neurosyphilis) during pregnancy or at the time of delivery. Results Of 314 infants documented to be exposed to infectious syphilis during gestation, 16 (5.1%) were stillborn. Three of the 16 females with stillbirths were diagnosed with syphilis during pregnancy but not treated, 12 were diagnosed only at the time of stillbirth (1 of whom was treated early in pregnancy and presumably reinfected), and 1 had a stillbirth in the week after one dose of benzathine penicillin G. Conclusions Stillbirths due to congenital syphilis were all due to failure to treat syphilis in pregnancy. Innovative strategies to prevent syphilis in the community and to reach those experiencing barriers to care are urgently required to not miss opportunities to diagnose and treat syphilis as early as possible during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%