Sensitivity Enhancement and Probiotic Detection of Microfluidic Chips Based on Terahertz Radiation Combined with Metamaterial Technology

Abstract

Terahertz (THz) radiation has attracted wide attention in recent years due to its non-destructive properties and ability to sense molecular structures. In applications combining terahertz radiation with metamaterial technology, the interaction between the terahertz radiation and the metamaterials causes resonance reactions; different analytes have different resonance performances in the frequency domain. In addition, a microfluidic system is able to provide low volume reagents for detection, reduce noise from the environment, and concentrate the sample on the detection area. Through simulation, a cruciform metamaterial pattern was designed; the proportion, periodicity, and width of the metamaterial were adjusted to improve the sensing capability of the chip. In the experiments, the sensing capabilities of Type A, B, and C chips were compared. The Type C chip had the most significant resonant effect; its maximum shift could be increased to 89 GHz. In the probiotic experiment, the cruciform chip could have a 0.72 GHz shift at a concentration of 0.025 mg/50 μL, confirming that terahertz radiation combined with a metamaterial microfluidic chip can perform low-concentration detection.

Microfluidic Distillation System for Separation of Propionic Acid in Foods

“…Microfluidics devices have many advantages, such as a lower sample and reagent consumption, cheaper cost, simpler operation, faster detection time, and improved sensitivity [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. As a result, they have found widespread uses in many fields nowadays, including biomedical analysis, food safety screening, drug development, and environmental monitoring [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Many micro-distillation systems have been proposed in recent years [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ].…”