Sensitivity enhancement of an open-cavity-based optoacoustic sensor

Peterson, Ralph; Solis, Steven; Zhang, Bailin; Huang, He; Ye, Jing Yong

doi:10.1364/ol.38.002739

Cited by 4 publications

References 12 publications

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Liver‐on‐a‐Chip Integrated with Label‐Free Optical Biosensors for Rapid and Continuous Monitoring of Drug‐Induced Toxicity

Yang,

Khorsandi,

Trabucco

et al. 2024

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Drug toxicity assays using conventional 2D static cultures and animal studies have limitations preventing the translation of potential drugs to the clinic. The recent development of organs‐on‐a‐chip platforms provides promising alternatives for drug toxicity/screening assays. However, most studies conducted with these platforms only utilize single endpoint results, which do not provide real‐time/ near real‐time information. Here, a versatile technology is presented that integrates a 3D liver‐on‐a‐chip with a label‐free photonic crystal‐total internal reflection (PC‐TIR) biosensor for rapid and continuous monitoring of the status of cells. This technology can detect drug‐induced liver toxicity by continuously monitoring the secretion rates and levels of albumin and glutathione S‐transferase α (GST‐α) of a 3D liver on‐a‐chip model treated with Doxorubicin. The PC‐TIR biosensor is based on a one‐step antibody functionalization with high specificity and a detection range of 21.7 ng mL−1 to 7.83 x 103 ng mL−1 for albumin and 2.20 ng mL−1 to 7.94 x 102 ng mL−1 for GST‐α. This approach provides critical advantages for the early detection of drug toxicity and improved temporal resolution to capture transient drug effects. The proposed proof‐of‐concept study introduces a scalable and efficient plug‐in solution for organ‐on‐a‐chip technologies, advancing drug development and in vitro testing methods by enabling timely and accurate toxicity assessments.

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Liver‐on‐a‐Chip Integrated with Label‐Free Optical Biosensors for Rapid and Continuous Monitoring of Drug‐Induced Toxicity

Yang,

Khorsandi,

Trabucco

et al. 2024

Small

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Non-contact Photoacoustic Imaging Using A Commercial Heterodyne Interferometer

Tian

Wang

et al. 2016

IEEE Sensors J.

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Most current photoacoustic imaging (PAI) systems employ piezoelectric transducers to receive photoacoustic signals, which requires coupling medium to facilitate photoacoustic wave propagation and are not favored in many applications. Here, we report an all-optical non-contact PAI system based on a commercial heterodyne interferometer working at 1550 nm. The interferometer remotely detects ultrasound-induced surface vibration and does not involve any physical contact with the sample. The theoretically predicated and experimentally measured noise equivalent detection limits of the optical sensor are about 4.5 and 810 Pa over 1.2 MHz bandwidth. Using a raster-scan PAI system equipped with the non-contact design, stereotactic boundaries of an artificial tumor in a pig brain were accurately delineated. The non-contact design also enables the tomographic PAI of biological tissue samples in a non-invasive manner. The preliminary results and analyses reveal that the heterodyne interferometer-based non-contact PAI system holds good potential in biomedical imaging.

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