Sensitivity improvement of Cerenkov luminescence endoscope with terbium doped Gd2O2S nanoparticles

Cao, Xin; Chen, Xueli; Kang, Fei; Cao, Xu; Zhan, Yonghua; Wang, Jing; Wu, Kaichun; Liang, Jimin

doi:10.1063/1.4921858

Cited by 12 publications

(5 citation statements)

References 17 publications

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“…The researchers explored this empirical concept using the modified Stober method for the preparation of the bifunctional Tb complex-based NPs. 145 Moreover, Xin Cao et al also indicated improvement in the sensitivity of the Cerenkov luminescence endoscope by using Tb-doped gadolinium oxide sulfate NPs for effective use in the clinical diagnosis of gastrointestinal tract tumors, 146 summarized in Figure 6(a−d).…”

Section: Diagnosismentioning

confidence: 99%

“…Following information pertains to the outcomes of the in vivo experiment: (a) an image of a hairless mouse, (b) a combined image of white light and luminescence that displays the local pseudotumor area captured via CLE, (c) a correlation between the intensity of emitted luminescence obtained through CLE and the activity of 68Ga, and (d) signal to background ratio (SBR) in relation to the activity of 68Ga, reproduced with permission from ref . Copyright 2015, AIP Publishing.…”

Section: Terbium-based Nps (Tbnps) For Biomedical Applicationsmentioning

confidence: 99%

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Potential Biomedical Applications of Terbium-Based Nanoparticles (TbNPs): A Review on Recent Advancement

Mohanto,

Biswas,

Gholap

et al. 2024

ACS Biomater. Sci. Eng.

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The scientific world is increasingly focusing on rare earth metal oxide nanomaterials due to their consequential biological prospects, navigated by breakthroughs in biomedical applications. Terbium belongs to rare earth elements (lanthanide series) and possesses remarkably strong luminescence at lower energy emission and signal transduction properties, ushering in wide applications for diagnostic measurements (i.e., bioimaging, biosensors, fluorescence imaging, etc.) in the biomedical sectors. In addition, the theranostic applications of terbium-based nanoparticles further permit the targeted delivery of drugs to the specific site of the disease. Furthermore, the antimicrobial properties of terbium nanoparticles induced via reactive oxygen species (ROS) cause oxidative damage to the cell membrane and nuclei of living organisms, ion release, and surface charge interaction, thus further creating or exhibiting excellent antioxidant characteristics. Moreover, the recent applications of terbium nanoparticles in tissue engineering, wound healing, anticancer activity, etc., due to angiogenesis, cell proliferation, promotion of growth factors, biocompatibility, cytotoxicity mitigation, and anti-inflammatory potentials, make this nanoparticle anticipate a future epoch of nanomaterials. Terbium nanoparticles stand as a game changer in the realm of biomedical research, proffering a wide array of possibilities, from revolutionary imaging techniques to advanced drug delivery systems. Their unique properties, including luminescence, magnetic characteristics, and biocompatibility, have redefined the boundaries of what can be achieved in biomedicine. This review primarily delves into various mechanisms involved in biomedical applications via terbium-based nanoparticles due to their physicochemical characteristics. This review article further explains the potential biomedical applications of terbium nanoparticles with in-depth significant mechanisms from the individual literature. This review additionally stands as the first instance to furnish a "single-platted" comprehensive acquaintance of terbium nanoparticles in shaping the future of healthcare as well as potential limitations and overcoming strategies that require exploration before being trialed in clinical settings.

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Section: Diagnosismentioning

confidence: 99%

Section: Terbium-based Nps (Tbnps) For Biomedical Applicationsmentioning

confidence: 99%

Potential Biomedical Applications of Terbium-Based Nanoparticles (TbNPs): A Review on Recent Advancement

Mohanto,

Biswas,

Gholap

et al. 2024

ACS Biomater. Sci. Eng.

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“…Carpenter et al [ 30 ] demonstrated the down-conversion of Cerenkov light emitted from 18 F by barium yttrium fluoride nanoscrystals doped with terbium and europium. Instead, excitation by 68 Ga terbium-doped Gd nanoparticles revealed a significant improvement in detection sensitivity for clinical diagnoses of gastrointestinal tract tumors [ 31 ]. The fact that gamma radiation is the major cause of Europium Oxide (EO) NP emissions was demonstrated by Hu et al [ 32 ].…”

Section: Nanoparticles For Imaging and Therapy Using Cerenkov Sourmentioning

confidence: 99%

Nanoparticles for Cerenkov and Radioluminescent Light Enhancement for Imaging and Radiotherapy

Boschi

Spinelli

2020

Nanomaterials

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Cerenkov luminescence imaging and Cerenkov photodynamic therapy have been developed in recent years to exploit the Cerenkov radiation (CR) generated by radioisotopes, frequently used in Nuclear Medicine, to diagnose and fight cancer lesions. For in vivo detection, the endpoint energy of the radioisotope and, thus, the total number of the emitted Cerenkov photons, represents a very important variable and explains why, for example, 68Ga is better than 18F. However, it was also found that the scintillation process is an important mechanism for light production. Nanotechnology represents the most important field, providing nanosctructures which are able to shift the UV-blue emission into a more suitable wavelength, with reduced absorption, which is useful especially for in vivo imaging and therapy applications. Nanoparticles can be made, loaded or linked to fluorescent dyes to modify the optical properties of CR radiation. They also represent a useful platform for therapeutic agents, such as photosensitizer drugs for the production of reactive oxygen species (ROS). Generally, NPs can be spaced by CR sources; however, for in vivo imaging applications, NPs bound to or incorporating radioisotopes are the most interesting nanocomplexes thanks to their high degree of mutual colocalization and the reduced problem of false uptake detection. Moreover, the distance between the NPs and CR source is crucial for energy conversion. Here, we review the principal NPs proposed in the literature, discussing their properties and the main results obtained by the proponent experimental groups.

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“…This strategy reduces the ambient noise using the inside of the living body as a dark space, and the proof of concept of endoscopic CLI results was therefore demonstrated. Through the development of novel imaging probes and imaging systems, the subsequent studies improved the performance of endoscopic CLI and the clinical translation potential was discussed . In 2015, endoscopic CLI succeeded to detect the gastrointestinal tumors in a clinical trial involved four patients .…”

Section: Introductionmentioning

confidence: 99%

A novel in vivo Cerenkov luminescence image‐guided surgery on primary and metastatic colorectal cancer

Zhang

Cao

et al. 2019

Journal of Biophotonics

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Intraoperative Cerenkov luminescence imaging (CLI) can effectively improve the performance of tumor surgery. Nevertheless, the existing approaches are still unsatisfying to the clinical demands of open surgery. This study develops a novel intraoperative in vivo CLI approach to investigate the potential and value of Cerenkov luminescence (CL) image‐guided surgery. A system characterized with high sensitivity (19.61 kBq mL−1 18F‐FDG) and desirable spatial resolution (88.34 μm) is developed. CL image‐guided surgery is performed on colorectal cancer (CRC) models of mice and swine. Tumor surgery is guided by the static CL images, and the resection quality is evaluated quantitatively and contrasted with other imaging modalities exemplified by bioluminescence imaging (BLI). The in vivo results demonstrated the effectiveness of the proposed intraoperative CLI approach for removing primary and metastatic CRC. Safety of performing in vivo CL image‐guided surgery is verified as well through radiation measurements of related staffs. Overall, the developed intraoperative in vivo CLI approach can efficiently improve the cancer treatment.

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Sensitivity improvement of Cerenkov luminescence endoscope with terbium doped Gd2O2S nanoparticles

Cited by 12 publications

References 17 publications

Potential Biomedical Applications of Terbium-Based Nanoparticles (TbNPs): A Review on Recent Advancement

Potential Biomedical Applications of Terbium-Based Nanoparticles (TbNPs): A Review on Recent Advancement

Nanoparticles for Cerenkov and Radioluminescent Light Enhancement for Imaging and Radiotherapy

A novel in vivo Cerenkov luminescence image‐guided surgery on primary and metastatic colorectal cancer

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