Sensitivity minimization, biological homeostasis and information theory

Biswas, Debojyoti; Iglesias, Pablo A.

doi:10.1007/s00422-021-00860-2

Cited by 5 publications

(1 citation statement)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…D 1 -like and D 2 -like receptors are both stimulated by APO [36]. According to the "high output/low sensitivity" homeostatic principle [37], subsensitivity of D 1 -like and D 2 -like receptors would be adaptive of an excess of presynaptic DA release from the mesolimbic DA system and its hypothalamic innervation [4,5,11]. In other words, in the chronic phase of the disease, long-term DAergic hyperactivity could lead to desensitization of DA receptors.…”

Section: Pathophysiologymentioning

confidence: 99%

Systematic Review of the Apomorphine Challenge Test in the Assessment of Dopaminergic Activity in Schizophrenia

Duval

2023

Healthcare

View full text Add to dashboard Cite

So far, neuroendocrine studies conducted in schizophrenic patients have yielded conflicting results. Many of these discrepancies may be explained by the diversity of factors that influence the hormonal levels (at baseline and in response to pharmacological stimuli), the heterogeneity of the populations studied, the absence of standardization of test challenges and the confounding and long-lasting effects of previous treatments. Numerous studies have used apomorphine (APO) in the evaluation of dopaminergic (DA) function in schizophrenic patients. APO, a direct acting DA receptor agonist, decreases prolactin (PRL) and stimulates growth hormone (GH), adrenocorticotropic hormone (ACTH) and cortisol secretion. Therefore, the magnitude of hormonal responses to APO is an indirect assessment of the functionality of DA receptors at the hypothalamic–pituitary level. This review provides an update on the applications of the APO test in schizophrenia in clinical, pathophysiological and therapeutic fields.

show abstract