Sensitivity of diagnostic tests for human soil-transmitted helminth infections: a meta-analysis in the absence of a true gold standard

Nikolay, Birgit; Brooker, Simon; Pullan, Rachel L.

doi:10.1016/j.ijpara.2014.05.009

Cited by 229 publications

(257 citation statements)

References 44 publications

(71 reference statements)

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“…25,38,39 A limitation of the Kato Katz technique for diagnosis of STH is that light infections may remain undiagnosed, especially for hookworm. 40 Thus, the light intensity of Trichuris and hookworm infections in this population may have led to an underestimation of prevalence of these species. The use of single stool samples further reduces the sensitivity of STH diagnosis.…”

Section: Discussionmentioning

confidence: 93%

Species-Specific Associations Between Soil-Transmitted Helminths and Micronutrients in Vietnamese Schoolchildren

Gier

Nga

Winichagoon

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Soil-transmitted helminth (STH) infections and micronutrient deficiencies are closely related and often coexist among low-income populations. We studied the association between infections with specific STH species and micronutrient status in rural Vietnamese schoolchildren. Children (N = 510) aged 6-9 years were recruited from two primary schools. STH infections were determined in stool samples. Hemoglobin, ferritin, retinol, and zinc were measured in blood samples, as well as C-reactive protein to control for inflammation. Iodine excretion was measured in urine. Associations of single and multiple infections with Ascaris lumbricoides, Trichuris trichiura, and hookworm with micronutrient status (hemoglobin, plasma ferritin, retinol, zinc, and urinary iodine) were estimated by multiple regression analysis. Ascaris infections showed a specific and intensity-dependent negative association with vitamin A. Trichuris and hookworm infections were associated with lower hemoglobin concentration, but not with plasma ferritin. Trichurisinfected children had zinc deficiency less often than uninfected children. In conclusion, our study shows species-specific associations between STH infections and micronutrient status in children. The different life cycles of STH species might have specific effects on the absorption or loss of specific micronutrients. Tailor-made combinations of deworming and nutritional interventions may be needed to improve child health and nutrition.

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Section: Discussionmentioning

confidence: 93%

Species-Specific Associations Between Soil-Transmitted Helminths and Micronutrients in Vietnamese Schoolchildren

Gier

Nga

Winichagoon

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…The use of a single faecal sample will underestimate the prevalence of STH. 36 The lack of funds and time and difficulties for village residents to provide samples when using open forest or coastal areas for defaecation limited the survey to a single sample per participant. The modified Kato-Katz technique may have also underestimated the prevalence and intensity since clearing of the faecal matter does not occur.…”

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confidence: 99%

Prevalence of soil-transmitted helminths in remote villages in East Kwaio, Solomon Islands

Harrington

Bradbury

Taeka³

et al. 2015

WPSAR

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“…According to some authors [40,41], if there is an absence of a true gold standard, meta-analysis can be applied, based on the comparison of the sensitivity and the quantitative performances of several methods. In their study, Nikolay et al (2014) [41] mentioned the following methods: Kato-Katz, direct microscopy, McMaster, FLOTAC and Mini-FLOTAC. The researchers concluded that the highest sensitivity was for the FLOTAC method and the lowest for the direct microscopy method.…”

Section: Correction Coefficients Of Counting Resultsmentioning

confidence: 99%

Division of methods for counting helminths’ eggs and the problem of efficiency of these methods

Jaromin-Gleń

Kłapeć

Łagód

et al. 2017

Ann Agric Environ Med.

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From the sanitary and epidemiological aspects, information concerning the developmental forms of intestinal parasites, especially the eggs of helminths present in our environment in: water, soil, sandpits, sewage sludge, crops watered with wastewater are very important. The methods described in the relevant literature may be classified in various ways, primarily according to the methodology of the preparation of samples from environmental matrices prepared for analysis, and the sole methods of counting and chambers/instruments used for this purpose. In addition, there is a possibility to perform the classification of the research methods analyzed from the aspect of the method and time of identification of the individuals counted, or the necessity for staining them. Standard methods for identification of helminths' eggs from environmental matrices are usually characterized by low efficiency, i.e. from 30% to approximately 80%. The efficiency of the method applied may be measured in a dual way, either by using the method of internal standard or the 'Split/Spike' method. While measuring simultaneously in an examined object the efficiency of the method and the number of eggs, the 'actual' number of eggs may be calculated by multiplying the obtained value of the discovered eggs of helminths by inverse efficiency.

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Sensitivity of diagnostic tests for human soil-transmitted helminth infections: a meta-analysis in the absence of a true gold standard

Cited by 229 publications

References 44 publications

Species-Specific Associations Between Soil-Transmitted Helminths and Micronutrients in Vietnamese Schoolchildren

Species-Specific Associations Between Soil-Transmitted Helminths and Micronutrients in Vietnamese Schoolchildren

Prevalence of soil-transmitted helminths in remote villages in East Kwaio, Solomon Islands

Division of methods for counting helminths’ eggs and the problem of efficiency of these methods

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