Sensitivity of Escherichia coli 0157:H7 Strain 932 to Selected Anticoccidial Drugs in Broiler Chicks

Abstract

The ability of selected anticoccidial drugs to inhibit the colonization of day-old male broiler chicks (Cornish Rocks) by Escherichia coli O157:H7, strain 932 was examined. Chicks were challenged with 1.8 x 10(9) E. coli O157:H7 on Day 1, and fed diets supplemented with three selected anticoccidial drugs; monensin, nicarbazin, or robenidine. The cecal and colon fecal contents of the chicks were removed on Day 7, 14, and 21 postinoculation and examined for the concentration of E. coli O157: H7 per gram of contents. Monensin effectively reduced cecal and colon colonization of the chicks by E. coli O157:H7. By Day 7, there were significant reductions in the bacterial population of the cecal contents of chicks receiving the monensin-medicated feed, and by Day 21 no E. coli O157:H7 was recovered from the cecal and colon contents. The bacterial counts in the colon contents of the nicarbazin- and robenidine-medicated and unmedicated chicks were significantly higher than the monensin-treated chicks. Bacterial populations in the colon contents were high only when there were high bacterial concentrations in the cecal contents.

Synthesis, physico-chemical and antimicrobial screening studies of some transition metal complexes with O:O donor ligands

“…It is well known from the literature that dehydroacetic acid (3-acetyl-6-methyl-pyran-2,4-dione) have a strong ability to form metal complexes. Besides its chelating ability, it also shows promising antifungal, antibacterial and antiprototozoal activities [9,10]. The present work deals with the studies of metal complexes of dehydroacetic acid and heterocyclic aldehydes so as to confirm whether there is enhancement in the biological activity due to complexation with transition metal ions.…”

Opinion of the Scientific Panel on additives and products or substances used in animal feed (FEEDAP) on the reevaluation of coccidiostat Elancoban in accordance with article 9G of Council Directive 70/524/EEC

“…The observations also indicated that monensin did not influence the shedding of Salmonella in naturally infected chickens. In chickens challenged with E. coli O 157, monensin reduced the number of this strain in caecum and colon, to the extent that by day 21 no E. coli O 157:H7 were detected (Stanley, et al, 1996). However, it should be noted that the dose used (227 mg kg -1 feed) was substantially above the maximum dose recommended.…”

An Efficient Synthesis of 3-(3-benzyl-2-(phenylimino)-2,3-dihydrothiazol-4-yl)-6-methyl-4-(2-oxo-2-phenylethoxy)-3,4-dihydro-2H-pyran-2-one DerivativesviaMulti-Component Approach

“…Dehydroacetic acid (3‐acetyl‐4‐hydroxy‐6‐methyl‐2 H ‐pyran‐2‐one) was reported to be an excellent chelating agent and possesses promising fungicidal, bactericidal, herbicidal, and insecticidal activities , it is also a versatile starting material for the synthesis of a wide variety of heterocyclic ring systems.…”