Sensitivity of fasting glucose for gestational diabetes mellitus screening in Mexican adolescents based on International Association of Diabetes and Pregnancy Study Groups criteria: a diagnostic accuracy study based on retrospective data analysis

Reyes-Muñoz, Enrique; Sandoval-Osuna, Norma Lidia; Reyes-Mayoral, Christian; Ortega-González, Carlos; Martínez-Cruz, Nayeli; Ramírez-Torres, María Aurora; Arce-Sánchez, Lidia; Lira-Plascencia, Josefina; Estrada-Gutiérrez, Guadalupe; Montoya-Estrada, Araceli

doi:10.1136/bmjopen-2018-021617

Cited by 11 publications

(6 citation statements)

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“…which also indicated that the first-trimester FPG of 80 mg/dL (4.44 mmol/L) is a good predictor for GDM [17]. The results by Reyes et al showed that the cutoff value of FPG of 90 mg/dL (5.0 mmol/L) was helpful to avoid unnecessary OGTT in 0.7% of pregnant women [18]. Different studies all highlighted the usefulness and importance of using FPG alone for the diagnosis of GDM.…”

Section: Discussionmentioning

confidence: 99%

Fasting plasma glucose in the first trimester is related to gestational diabetes mellitus and adverse pregnancy outcomes

Tong

Chen

et al. 2021

Endocrine

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Purpose To investigate and identify first-trimester fasting plasma glucose (FPG) is related to gestational diabetes mellitus (GDM) and other adverse pregnancy outcomes in Shenzhen population. Methods We used data of 48,444 pregnant women that had been retrospectively collected between 2017 and 2019. Logistic regression analysis was used to evaluated the associations between first-trimester FPG and GDM and adverse pregnancy outcomes, and used to construct a nomogram model for predicting the risk of GDM. The performance of the nomogram was evaluated by using ROC and calibration curves. Decision curve analysis (DCA) was used to determine the clinical usefulness of the first-trimester FPG by quantifying the net benefits at different threshold probabilities. Results The mean first-trimester FPG was 4.62 ± 0.42 mmol/L. A total of 6998 (14.4%) pregnancies developed GDM.489(1.01%) pregnancies developed polyhydramnios, the prevalence rates of gestational hypertensive disorder (GHD), cesarean section, primary cesarean section, preterm delivery before 37 weeks (PD) and dystocia was 1130 (2.33%), 20,426 (42.16%), 7237 (14.94%), 2386 (4.93%), and 1865 (3.85%), respectively. 4233 (8.74%) of the newborns were LGA, and the number of macrosomia was 2272 (4.69%), LBW was 1701 (3.51%) and 5084 (10.49%) newborns had admission to the ICU, which all showed significances between GDM and non-GDM groups (all P < 0.05). The univariate analysis showed that first-trimester FPG was strongly associated with risks of outcomes including GDM, cesarean section, macrosomia, GHD, primary cesarean section, and LGA (all OR > 1, all P < 0.05), furthermore, the risks of GDM, primary cesarean section, and LGA was increasing with first-trimester FPG as early as it was at 4.19–4.63 mmol/L. The multivariable analysis showed that the risks of GDM (ORs for FPG 4.19–4.63, 4.63–5.11 and 5.11–7.0 mmol/L were 1.137, 1.592, and 4.031, respectively, all P < 0.05) increased as early as first-trimester FPG was at 4.19–4.63 mmol/L, and first-trimester FPG which was also associated with the risks of cesarean section, macrosomia and LGA (OR for FPG 5.11–7.0 mmol/L of cesarean section: 1.128; OR for FPG 5.11–7.0 mmol/L of macrosomia: 1.561; OR for FPG 4.63–5.11 and 5.11–7.0 mmol/L of LGA: 1.149 and 1.426, respectively, all P < 0.05) and with its increasing, the risks of LGA increased. Furthermore, the nomogram had a C-indices 0.771(95% CI: 0.763~0.779) and 0.770(95% CI:0.758~0.781) in training and testing validation respectively, which showed an acceptable consistency between the observed, validation and nomogram-predicted probabilities, the DAC curve analysis indicated that the nomogram had important clinical application value for GDM risk prediction. Conclusions FPG in the first trimester was an independent risk factor for GDM which can be used as a screening test for identifying pregnancies at risk of GDM and adverse pregnancy outcomes.

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Section: Discussionmentioning

confidence: 99%

Fasting plasma glucose in the first trimester is related to gestational diabetes mellitus and adverse pregnancy outcomes

Tong

Chen

et al. 2021

Endocrine

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“…GD is usually underdiagnosed, since the various reported prevalence values depend on the studied population and method used; furthermore GD diagnosis often depend on the population or geographical area and evidence to support the diagnostic process [25] , [26] , [27] , [28] .…”

Section: Discussionmentioning

confidence: 99%

Glucose metabolism in gestational diabetes and their relationship with fat mass / muscle mass index

María de los Angeles,

del Socorro,

Hugo

et al. 2024

European Journal of Obstetrics & Gynecology and Reproductiv

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“…First, we used fasting capillary blood glucose to diagnose GDM due to a lack of resources for oral glucose tolerance tests, which might affect the strength of recommendations. However, various studies have reported fasting capillary glucose as the most sensitive and specific test56 57 and recommended to be conducted in resource-limited settings 56. Second, even though capillary blood glucose is recommended in resource-limited settings, it is less sensitive than venous blood glucose.…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors of gestational diabetes mellitus in Goba town, Southeast Ethiopia: a prospective cohort study

et al. 2022

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ObjectiveGestational diabetes mellitus (GDM) is becoming a public health concern in low/middle-income countries, and is known to cause severe morbidity and mortality for mothers and newborns. However, evidence reported for the incidence and risk factors of GDM is scant in Ethiopia. We aimed to assess the incidence of, and risk factors for, GDM in Goba town, Southeast Ethiopia.DesignProspective cohort study.SettingGoba town, Southeast Ethiopia.ParticipantsFour hundred eighty pregnant women on antenatal care follow-up from 30 April to 30 September 2021.Primary and secondary outcomesIncidence and risk factors of GDM using fasting capillary blood glucose. Log-binomial model was used to identify the risk factors of GDM. Adjusted relative risk (aRR), along with 95% CIs, were calculated to estimate the strength of associations.ResultsThe cumulative incidence rate of GDM in this study was 15.7% (95% CI: 12.3% to 19.2%). Being unemployed (aRR=2.73; 95% CI: 1.36 to 5.47), having a family history of diabetes mellitus (DM) (3.01; 2.09 to 4.35), low physical activity (2.43; 1.11 to 5.32), inadequate dietary diversity (1.48; 1.29 to 1.92), anaemia (2.51; 1.32 to 3.54) and antenatal depression (4.95; 3.35 to 7.31) were significantly associated with GDM.ConclusionThe cumulative incidence of GDM was relatively high among the study participants. Having antenatal depression symptoms, low physical activity, inadequate dietary diversity, being unemployed, anaemia and a family history of DM were significant risk factors for GDM.

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Sensitivity of fasting glucose for gestational diabetes mellitus screening in Mexican adolescents based on International Association of Diabetes and Pregnancy Study Groups criteria: a diagnostic accuracy study based on retrospective data analysis

Cited by 11 publications

References 28 publications

Fasting plasma glucose in the first trimester is related to gestational diabetes mellitus and adverse pregnancy outcomes

Fasting plasma glucose in the first trimester is related to gestational diabetes mellitus and adverse pregnancy outcomes

Glucose metabolism in gestational diabetes and their relationship with fat mass / muscle mass index

Incidence and risk factors of gestational diabetes mellitus in Goba town, Southeast Ethiopia: a prospective cohort study

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