Sensitivity of photoacoustic microscopy

Yao, Junjie; Wang, Lihong V.

doi:10.1016/j.pacs.2014.04.002

Cited by 333 publications

(291 citation statements)

References 139 publications

(239 reference statements)

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“…with pulsed laser sources. In time-domain much larger photoacoustic pressures can be generated 2 . However, recently it was reported that frequency-domain PAM can achieve similar signal-to-noise ratios under the fulfillment of several requirements 3 .…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic microscopy of single cells employing an intensity-modulated diode laser

Langer

Buchegger

Jacak

et al. 2018

Photons Plus Ultrasound: Imaging and Sensing 2018

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Section: Introductionmentioning

confidence: 99%

Photoacoustic microscopy of single cells employing an intensity-modulated diode laser

Langer

Buchegger

Jacak

et al. 2018

Photons Plus Ultrasound: Imaging and Sensing 2018

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“…However, piezoelectric transducers have physical limitations. First, there is an inherent tradeoff between element size and signal-to-noise ratio (SNR) [1]. While large piezoelectric transducers in principle offer low thermal noise and high sensitivity, their surface shape must be well matched to the pressure wavefront to allow a high numerical aperture (NA) for photoacoustic microscopy (PAM) [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…First, there is an inherent tradeoff between element size and signal-to-noise ratio (SNR) [1]. While large piezoelectric transducers in principle offer low thermal noise and high sensitivity, their surface shape must be well matched to the pressure wavefront to allow a high numerical aperture (NA) for photoacoustic microscopy (PAM) [1,2]. This can be achieved by employing focused transducers [3] or acoustic lenses [4]; however, both approaches limit the transducer's effective field of view (FOV) to the acoustic focal spot size, making mechanical scanning of the transducer necessary to cover the desired field of view.…”

Section: Introductionmentioning

confidence: 99%

“…Mechanical scanning limits the frame rate in fast-scanning optical resolution photoacoustic microscopy (OR-PAM). Fast-scanning can be achieved with unfocused transducers [5] but without focusing the sensitivity is significantly reduced [1]. Because piezoelectric transducers are generally opaque, they cannot be placed in the optical path of the excitation laser, a further limitation for reflection mode OR-PAM systems.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

All-optical highly sensitive akinetic sensor for ultrasound detection and photoacoustic imaging

Preißer¹,

Rohringer²,

et al. 2016

Biomed. Opt. Express

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A novel all-optical akinetic ultrasound sensor, consisting of a rigid, fiber-coupled Fabry-Pérot etalon with a transparent central opening is presented. The sensing principle relies exclusively on the detection of pressure-induced changes of the refractive index in the fluid filling the Fabry-Pérot cavity. This enables resonance-free, inherently linear signal detection over a broad bandwidth. We demonstrate that the sensor achieves a exceptionally low peak noise equivalent pressure (NEP) values of 2 Pa over a 20 MHz measurement bandwidth (without signal averaging), while maintaining a flat frequency response, and a detection bandwidth up to 22.5 MHz (-6 dB). The measured large full field of view of the sensor is 2.7 mm × 1.3 mm and the dynamic range is 137 dB/ √ Hz or 63 dB at 20 MHz bandwidth. For different required amplitude ranges the upper amplitude detection limit can be customized from at least 2 kPa to 2 MPa by using cavity mirrors with a lower optical reflectivity. Imaging tests on a resolution target and on biological tissue show the excellent suitability of the akinetic sensor for optical resolution photoacoustic microscopy (OR-PAM) applications. functional photoacoustic microscopy of mouse brain in action," Nat. Methods 12, 407-410 (2015). 7. L. Xi, C. Song, and H. Jiang, "Confocal photoacoustic microscopy using a single multifunctional lens," Opt. Lett. 39, 3328-3331 (2014). 8. J. Gateau, A. Chekkoury, and V. Ntziachristos, "Ultra-wideband three-dimensional optoacoustic tomography," Opt.Lett. 38, 4671-4674 (2013). 9. C. Zhang, T. Ling, S.-L. Chen, and L. J. Guo, "Ultrabroad bandwidth and highly sensitive optical ultrasonic detector for photoacoustic imaging," ACS Photonics 1, 1093-1098 (2014). 10. E. Zhang, J. Laufer, and P. Beard, "Backward-mode multiwavelength photoacoustic scanner using a planar Fabry-Pérot polymer film ultrasound sensor for high-resolution three-dimensional imaging of biological tissues," Appl. Opt. photoacoustic microscopy using a digital micromirror device," Opt. Lett. 38, 1683-2686 (2013).

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“…The main advantage against other imaging modalities is simultaneously high spatial resolution, good contrast and a high penetration depth [3].…”

Section: Introductionmentioning

confidence: 99%

A Problem of a Displacement Calculation of Tissue Surface in Non-Contact Photoacoustic Tomography

Verbytskyi

Münter

Buj

et al. 2017

Research Bulletin of the National Technical University of Ukraine "Kyiv Politechnic Institute"

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Background. Photoacoustic tomography (PAT) is a relatively new imaging modality,which allows e.g. visualizing the vascular network in biological tissue noninvasively. This tomographic method has an advantage in comparison to pure optical/acoustical methods due to high optical contrast and low acoustic scattering in deep tissue. The common PAT methodology, based on measurements of the acoustic pressure by piezoelectric sensors placed on the tissue surface, limits its practical versatility. A novel, completely non-contact and full-field PAT system is described. In noncontact PAT the measurement of surface displacement induced by the acoustic pressure at the tissue/air border is researched. Objective. To solve a simulation problem of the displacement calculation based on the medium pressure, which consists in deriving a formula for recalculating the pressure in the surface displacement based on the momentum conservation law, developing a simulation technique, and comparing the error of the proposed technique with the earlier used one. Methods. Comparing the experimental data with simulated pressure data in the k-Wave toolbox. The criterion of comparison is the relative quadratic error. Results. The simulation results of the displacement based on a new approach are more consistent with the experimental data than previous. The quadratic error numerical value of the new approach is 18% and the previous is 71%. Conclusions. The theoretical features of the surface displacement simulation are investigated and the solution of this problem is proposed based on momentum conservation law. The implementation of the proposed methodology has a four times smaller simulation error compared to the previous technique, so it can be implemented in the non-contact PAT. The residual error can be caused by the properties of the tissue, which are not taken into account in the model, which requires further research.

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Sensitivity of photoacoustic microscopy

Cited by 333 publications

References 139 publications

Photoacoustic microscopy of single cells employing an intensity-modulated diode laser

Photoacoustic microscopy of single cells employing an intensity-modulated diode laser

All-optical highly sensitive akinetic sensor for ultrasound detection and photoacoustic imaging

A Problem of a Displacement Calculation of Tissue Surface in Non-Contact Photoacoustic Tomography

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