Sensitivity of pigmented mucosa and skin to freezing injury

Experimental cryosurgery investigations in vivo

“…Long-term observation showed some thinning of the skin. Experiments by other investigators showed the sensitivity of melanocytes, hair follicles, and skin glands to mild freezing temperature [68,141]. The resistance of collagen fibers in skin to damage from freezing is the basis for favorable healing.…”

Successful treatment of solar lentigines by brief gentle cryosurgery using a Kryomed®device

“…S ir , Solar lentigines are common benign melanocytic proliferations representing a cosmetic problem in older Caucasian individuals. Melanocytes are the most vulnerable skin cells to cold and are destroyed at −4 to −7 °C 1 . Indeed, Zouboulis et al .…”

Comparison of two devices for the treatment of keloid scars with the use of intralesional cryotherapy: An experimental study

“…Besides the internal tissue temperature (superficial and deep thermocouple), the outer surface temperature (thermo camera) was also measured in this study. The surface temperature is relevant, because melanocytes, located in the surface epithelium, are very sensitive to low temperatures and die at À4 to À7°C [5,15]. When temperatures reach below À20°C to À30°C, no repigmentation occurs [5].…”