When applied to blisk blade profile polishing of aero-engines, “five-axis NC + flexible grinding head + elastic grindstone” polishing technological equipment has advantages of high precision, minor interference, favorable adaptivity, etc. In order to improve the polishing quality and polishing efficiency, a mathematical calculation formula of polishing efficiency was established according to the polishing principles of elastic grindstone (sanding wheel). The optimized combination of technological parameters ( ω = 6000 r/min, ap = 0.9 mm, vf = 320 mm/min) was obtained through the range method of orthogonal test results with double optimization objectives—surface roughness and polishing efficiency. Based on the relationship between number of polishing times and surface roughness, a technological program was put forward, that is, polishing is firstly conducted using 320# sanding wheel for 6 times and then 400# sanding wheel for 9 times (totally 15 times) under the optimized combination of technological parameters, then surface roughness less 0.4 μm can be achieved. Blade polishing test results indicate that: efficiency-optimized technological parameters can not only significantly shorten polishing time but also acquire qualified blade surface roughness less 0.4 μm, thus verifying reliability of the optimization method and results.