Sensitivity to antimicrobial agents of bacteria involved into the development of aphthous stomatitis

Abstract

The microflora of the oral cavity plays a major role in the development of aphthous stomatitis. Therefore, the schemes of complex treatment of such patients necessarily include antimicrobial agents. The low effectiveness of the treatment of patients with aphthous stomatitis can be due to errors in the choice of the drug in the absence of information on the sensitivity of etiologically significant bacteria to antimicrobial agents. The aim of the work was to study the sensitivity of microorganisms isolated from the aphthae of patients with aphthous stomatitis to antimicrobial drugs. The determination was carried out using the disk-diffusion and serial dilutions of drugs in a liquid nutrient medium methods. Streptococci, which were most often isolated from the contents of aphthae, were sensitive to the vast majority of the studied drugs. Polyresistant to antibiotics were not found among the isolated strains of Staphylococcus aureus. The isolated strains of enterobacteria showed the highest (92.9%) level of sensitivity to the drug from a number of aminoglycosides, amikacin. 85.7% of the isolated strains were sensitive to amoxacillin protected by clavulanic acid. While only 21.4% of enterobacteria strains were sensitive to unprotected amoxacillin. A high level of sensitivity of the research strains of microorganisms to surface-active antiseptics chlorhexidine bigluconate, benzalkonium chloride and decamethoxine was found. Special attention was drawn to the high antimicrobial activity against microorganisms that take part in the development of aphthous stomatitis, an antiseptic from a number of quaternary ammonium compounds of decamethoxine. It is necessary to develop a new dosage form of the drug that would ensure a long-term stay of the antiseptic on the mucous membrane, which is constantly and abundantly washed with oral secretions. Keywords: opportunistic bacteria, resistance to antibiotics and antiseptics, microflora of aphthous content.