Sensitization and Allergy to &lt;i&gt;Cannabis sativa&lt;/i&gt; Leaves in a Population of Tomato &lt;i&gt;(Lycopersicon esculentum)&lt;/i&gt;-Sensitized Patients

Larramendi, Carlos H.; Carnés, Jerónimo; García-Abujeta, José Luis; García-Endrino, A; Muñoz-Palomino, Elena; Huertas, A.J.; Fernández-Caldas, Enrique; Ferrer, A.

doi:10.1159/000115887

Cited by 35 publications

(38 citation statements)

References 41 publications

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“…6 Paradoxically, the protective action of cannabis against allergies has also been described. 7 Cross-reactivity between cannabis and tomato allergens 8 and skin lesions due to inhalation of cannabis have been reported. 9 Allergic hypersensitivity to tobacco has been demonstrated by our group in a large series of patients.…”

Section: Discussionmentioning

confidence: 99%

Allergic hypersensitivity to cannabis in patients with allergy and illicit drug users

Armentia

Castrodeza²,

Ruiz-Muñoz³

et al. 2011

Allergologia et Immunopathologia

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Background: Cannabis is the illicit drug most widely used by young people in high-income countries. Allergy symptoms have only occasionally been reported as one of the adverse health effects of cannabis use. Objectives: To study IgE-mediated response to cannabis in drug users, atopic patients, and healthy controls. Methods: Asthmatic patients sensitised to pollen, and all patients sensitised to tobacco, tomato and latex, considered as cross-reacting allergens, were selected from a data base of 21,582 patients. Drug users attending a drug-rehabilitation clinic were also included. Controls were 200 non-atopic blood donors. Specific IgE determination, prick tests and specific challenge with cannabis extracts were performed in patients and controls. Results: Overall, 340 patients, mean age 26.9 ± 10.7 years, were included. Males (61.4%) were the most sensitised to cannabis (p < 0.001). All cannabis-sensitised patients were alcohol users. Eighteen (72%) of the patients allergic to tomato were sensitised to cannabis, but a positive specific challenge to cannabis was highest in patients sensitised to tobacco (13/21, 61.9%), (p < 0.001). Pollen allergy was not a risk factor for cannabis sensitisation. Prick tests and IgE for cannabis had a good sensitivity (92 and 88.1%, respectively) and specificity (87.1 and 96%) for cannabis sensitisation. Conclusions: Cannabis may be an important allergen in young people. Patients previously sensitised to tobacco or tomato are at risk. Cannabis prick tests and IgE were useful in detecting sensitisation.

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Section: Discussionmentioning

confidence: 99%

Allergic hypersensitivity to cannabis in patients with allergy and illicit drug users

Armentia

Castrodeza²,

Ruiz-Muñoz³

et al. 2011

Allergologia et Immunopathologia

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“…Larramendi et al (2013) described six different bands with a molecular weight of 10-, 14-, 20-, 35-, 38-and 60-kDa that were recognized by the individual patients' sera. The 10-kDa IgE-binding band was already described in other reports (de Larramendi et al 2008;Gamboa et al 2007;Tanaka et al 1998) and most likely corresponds to Can s 3, the ns-LTP of C. sativa (Gamboa et al 2007) that belongs to the pathogenesis-related proteins (PR)-14 group (Van Loon 1999). In a study by Armentia et al (2014), sensitization to the purified cannabis ns-LTP was observed in 124 out of 130 patients (95.3 %) with a primary cannabis allergy.…”

Section: Cannabis Allergensmentioning

confidence: 54%

“…Although in the study of Larramendi et al (2013), no homology was found between the 14-kDa band and any known allergen, it was speculated that this band could be a profilin (de Larramendi et al 2008).…”

Section: Cannabis Allergensmentioning

confidence: 95%

“…Presently, sensitization and allergy to cannabis are almost exclusively studied or documented by prick-prick skin testing. Prick-prick skin tests use a broad variety of raw materials such as macerated C. sativa leaves, buds and flowers de Larramendi et al 2008;Ebo et al 2013;Gamboa et al 2007;Larramendi et al 2013;Metz-Favre et al 2011;Nayak et al 2013;Stadtmauer et al 2003;Tessmer et al 2012). Needless to say, this approach is virtually impossible to standardize, mainly because of unpredictable variations in composition and potential contaminations with other allergens of the raw material.…”

Section: Diagnosismentioning

confidence: 99%

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Cannabis Allergy: What do We Know Anno 2015

Decuyper

Ryckebosch

Gasse

et al. 2015

Arch. Immunol. Ther. Exp.

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For about a decade, IgE-mediated cannabis (marihuana) allergy seems to be on the rise. Both active and passive exposure to cannabis allergens may lead to a cannabis sensitization and/or allergy. The clinical manifestations of a cannabis allergy can vary from mild to lifethreatening reactions, often depending on the route of exposure. In addition, sensitization to cannabis allergens can trigger various secondary cross-allergies, mostly for plant-derived food. This clinical entity, which we have designated as the ''cannabis-fruit/vegetable syndrome'' might also imply cross-reactivity with tobacco, latex and plant-food derived alcoholic beverages. These secondary cross-allergies are mainly described in Europe and appear to result from cross-reactivity between non-specific lipid transfer proteins or thaumatin-like proteins present in Cannabis sativa and their homologues that are ubiquitously distributed throughout plant kingdom. At present, diagnosis of cannabis-related allergies rests upon a thorough history completed with skin testing using native extracts from buds and leaves. However, quantification of specific IgE antibodies and basophil activation tests can also be helpful to establish correct diagnosis. In the absence of a cure, treatment comprises absolute avoidance measures including a stop of any further cannabis (ab)use.

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“…1 As a result of the increasing social and medical usage, reports of allergic sensitization to marijuana are increasing in the peer reviewed literature. [2][3][4][5][6][7][8][9][10] Cases have been reported where hypersensitivity and even anaphylactic responses have been associated with marijuana use and clinical symptoms include sore throat, nasal congestion, rhinitis, pharyngitis, wheezing, dyspnea, angioedema and lacrimation. 2-4, 11, 12 In chronic and high dose users more severe manifestations of bronchitis and asthma with reduced vital capacity have been reported.…”

Section: Introductionmentioning

confidence: 99%