Sensitization and Habituation: Invertebrate

Fioravante, Diasinou; Antzoulatos, Evan G.; Byrne, John H.

doi:10.1016/b978-012370509-9.00005-x

Cited by 7 publications

(5 citation statements)

References 219 publications

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“…Sensitization of organisms to training stimuli can be induced by one of two ways. 20,21 Firstly, it can be induced by presentation of a noxious stimulus. A dramatic increment of the behaviour response may occur when a noxious stimulus is applied immediately after a series of gentle stimuli.…”

Section: The Implementation Of Sensitizationmentioning

confidence: 99%

“…This experience-induced accommodation of behaviour is a modality of learning and can be divided into two forms, associative learning and nonassociative learning. 20,21 The associative learning indicates that an organism knows about the relationship between two events or stimuli, including classical and operant conditioning. 22 While the nonassociative learning demonstrates that an animal learns about the occurrence or characteristics of a single stimulus.…”

Section: Introductionmentioning

confidence: 99%

“…On the contrary, sensitization is biologically defined as the augment of a behavioural response aroused by noxious stimuli or a moderate stimulus (e.g., electric shock) repeatedly with a short interval. 20,21,28 Different from habituation, the sensitization is a more complex process which is not only attributed to the synaptic facilitation, but also partly to the neuromodulator, such as serotonin (5-HT). 29,30 In sensitization behaviour, the interneuron (IN) between sensory and motor neurons plays an important role that it will activate and release neuromodulators to change the synaptic weight and excite the motor neuron in response to nerve stimulation.…”

Section: Introductionmentioning

confidence: 99%

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Nonassociative learning implementation by a single memristor-based multi-terminal synaptic device

Yang

Fang

et al. 2016

Nanoscale

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Animals' survival is dependent on their abilities to adapt to the changing environment by adjusting their behaviours, which is related to the ubiquitous learning behaviour, nonassociative learning. Thus mimicking the indispensable learning behaviour in organisms based on electronic devices is vital to better achieve artificial neural networks and neuromorphic computing. Here a three terminal device consisting of an oxide-based memristor and a NMOS transistor is proposed. The memristor with gradual conductance tuning inherently functions as the synapse between sensor neurons and motor neurons and presents adjustable synaptic plasticity, while the NMOS transistor attached to the memristor is utilized to mimic the modulatory effect of the neuromodulator released by inter neurons. Such a memristor-based multi-terminal device allows the practical implementation of significant nonassociative learning based on a single electronic device. In this study, the experience-induced modification behaviour, both habituation and sensitization, was successfully achieved. The dependence of the nonassociative behavioural response on the strength and interval of presented stimuli was also discussed. The implementation of nonassociative learning offers feasible and experimental advantages for further study on neuromorphic systems based on electronic devices.

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Section: The Implementation Of Sensitizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nonassociative learning implementation by a single memristor-based multi-terminal synaptic device

Yang

Fang

et al. 2016

Nanoscale

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“…The cellular and molecular mechanisms underlying LTM have been extensively studied in monosynaptic connections between identified sensory neurons (SN) and motor neurons (MN) that mediate withdrawal reflexes of Aplysia (Zhao et al, 2003; Sharma and Carew, 2004; Lee et al, 2007; Fioravante et al, 2008; Kandel, 2009). Application of 5-HT, a neurotransmitter that mimics sensitization training, facilitates this synaptic connection (Montarolo et al, 1986; Emptage and Carew, 1993; Zhang et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

The Requirement for Enhanced CREB1 Expression in Consolidation of Long-Term Synaptic Facilitation and Long-Term Excitability in Sensory Neurons ofAplysia

Liu¹,

Cleary²,

Byrne³

2011

J. Neurosci.

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Accumulating evidence suggests that the transcriptional activator CREB1 is important for serotonin (5-HT)-induced long-term facilitation (LTF) of the sensorimotor synapse in Aplysia. Moreover, creb1 is among the genes activated by CREB1, suggesting a role for this protein beyond the induction phase of LTF. The time course of the requirement for CREB1 synthesis in the consolidation of long-term facilitation was examined using RNA interference (RNAi) techniques in sensorimotor co-cultures. Injection of CREB1 small-interfering RNA (siRNA) immediately or 10 h after 5-HT treatment blocked LTF when measured at 24 h and 48 h after treatment. In contrast, CREB1 siRNA did not block LTF when injected 16 h after 5-HT treatment. These results demonstrate that creb1 expression must be sustained for a relatively long time in order to support the consolidation of LTF. In addition, LTF is also accompanied by a long-term increase in the excitability (LTE) of sensory neurons (SNs). Because LTE was observed in the isolated SN after 5-HT treatment, this long-term change was intrinsic to that element of the circuit. LTE was blocked when CREB1 siRNA was injected into isolated SNs immediately after 5-HT treatment. These data suggest that 5-HT-induced CREB1 synthesis is required for consolidation of both LTF and LTE.

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“…Learning is the process of acquiring new or modifying existing knowledge, behaviors, skills, values, or preferences [1]. Survival of organisms is dependent on their experienceinduced learning capacity to adapt to the environment by modifying their behavior [2]. Learning can be divided into two general categories: associative and nonassociative [3].…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous stimuli induced nonassociative learning behavior in ZnO nanowire memristor

et al. 2020

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Nonassociative learning is a biologically essential and evolutionarily adaptive behavior in organisms. The bionic simulation of nonassociative learning based on electronic devices is essential to the neuromorphic computing. In this work, nonassociative learning is mimicked by a ZnO nanowire memristor without any other peripheral control circuit. The memristor demonstrates habituation and sensitization behaviors at the electrical and optical stimuli. Typical network-level parametric characteristics of habituation in neuroscience are realized in the memristor. When the heterogeneous stimuli are applied coincidentally, sensitization pulse could be identified by the exceptional response current. The results show that the natural selection rules could be simulated by the current single memristor. A possible mechanism based on the trapping states and adsorption of oxygen at the interface of Au/ZnO is proposed. The implementation of nonassociative learning in a single memristor device paves the way for building neuromorphic systems by simple electronic devices.

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Sensitization and Habituation: Invertebrate

Cited by 7 publications

References 219 publications

Nonassociative learning implementation by a single memristor-based multi-terminal synaptic device

Nonassociative learning implementation by a single memristor-based multi-terminal synaptic device

The Requirement for Enhanced CREB1 Expression in Consolidation of Long-Term Synaptic Facilitation and Long-Term Excitability in Sensory Neurons ofAplysia

Heterogeneous stimuli induced nonassociative learning behavior in ZnO nanowire memristor

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