2007
DOI: 10.1186/1471-2210-7-s2-a18
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Sensitization of cAMP formation in a neuron-like cell line

Abstract: Differentiation into a nerve cell-like phenotype and growth arrest of SH-SY5Y neuroblastoma cells went along with increased cAMP formation. Both receptor-dependent as well as direct activation of adenylyl cyclase by forskolin were enhanced by at least twenty-fold. Since cAMP controls many processes in nerve cell function and development we have investigated the causal factors and mechanism of sensitization in SH-SY5Y cells. The degree of sensitization depended on pre-incubation of the cells with retinoic acid;… Show more

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“…Several of these features are altered in FX. In addition, EphB2, a key component in dendritic spine formation with contributions to abnormal pruning in FX (Ethell, Irie et al 2001;Henkemeyer and Frisen 2001;Irie and Yamaguchi 2004), is a likely candidate to influence development of cAMP responsiveness to forskolin (Ibrisimovic, Bilban et al 2007). The mechanism for the distinctive development of the FX cAMP response remains unknown (Kelley, Davidson et al 2007) but the maturation of AC responsiveness in FX is likely related to FMRP loss or its downstream consequences.…”
Section: Cyclic Amp Theory Of Fragile Xmentioning
confidence: 99%
“…Several of these features are altered in FX. In addition, EphB2, a key component in dendritic spine formation with contributions to abnormal pruning in FX (Ethell, Irie et al 2001;Henkemeyer and Frisen 2001;Irie and Yamaguchi 2004), is a likely candidate to influence development of cAMP responsiveness to forskolin (Ibrisimovic, Bilban et al 2007). The mechanism for the distinctive development of the FX cAMP response remains unknown (Kelley, Davidson et al 2007) but the maturation of AC responsiveness in FX is likely related to FMRP loss or its downstream consequences.…”
Section: Cyclic Amp Theory Of Fragile Xmentioning
confidence: 99%