Sensitization of infant red cells by bacterial polysaccharides of Escherichia coli during enteritis

Young, Viola Mae; Gillen, Harriette C.; Akeroyd, Joseph H.

doi:10.1016/s0022-3476(62)80032-8

Cited by 22 publications

(6 citation statements)

References 15 publications

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“…Andersen [2] reported similar findings. Young et al [38] were able to show that the red cells from infants suffering from enteritis due to E. coli infection, were coated, in vivo, with bacterial polysaccharide. Springer and Horton [31] confirmed and extended these findings in infants and chickens.…”

Section: Discussionmentioning

confidence: 99%

An Acquired B Antigen Associated with Proteus vulgaris Infection

Garratty

Willbanks

Petz³

1971

Vox Sanguinis

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A group A(1) patient was found to have a weak B antigen present on his cells with an anti-B in his serum. Another weaker T-like antigen was also present on the cells. Both these antigens were transient and associated with a Proteus vulgaris bacteremia. The acquired B antigen was shown to react with a specific fraction of anti-B which was missing from the patient’s anti-B. The relevance of this and the theories of B antigen acquisition through bacteria are discussed.

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Section: Discussionmentioning

confidence: 99%

An Acquired B Antigen Associated with Proteus vulgaris Infection

Garratty

Willbanks

Petz³

1971

Vox Sanguinis

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“…In infections with Escherichia coli, the red cells have been found to adsorb bacterial antigens (31). PRP binds to washed red cells in saline (8) For example, pancreatic RNAase degrades PRP in vitro (32).…”

Section: Of the 70 Children Admitted To The Children's Hospitalmentioning

confidence: 99%

Circulating polyribophosphate in Hemophilus influenzae, type b meningitis. Correlation with clinical course and antibody response.

O'Reilly¹,

Anderson²,

Ingram³

et al. 1975

J. Clin. Invest.

117

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A B S T R A C T In systemic infections caused by Hemophilus influenzae, type b, the capsular polysaccharide, polyribophosphate, is released into the circulation. Polyribophosphate was quantitated in serial serum and cerebrospinal fluid samples from 45 children with H. influenzae, type b meningitis by means of a radiolabeled antigen-binding inhibition assay. Polyribophosphate was regularly found in acute serum and cerebrospinal fluid samples and could be detected in unbound form for periods of 1-30 days after initiation of effective therapy. Complexes of polyribophosphate dissociable with acid and pepsin were detected in serum samples from 17 patients, in one case for a period of 145 days after hospitalization. Polyribophosphate levels and patterns of clearance were studied in relation to hospital course and antibody response. Patients with prolonged antigenemia had protracted fevers and severe neurological symptoms during hospitalization, frequently with focal complications. Antipolyribophosphate antibody responses were detected during the first 100 days of convalescence by radioimmunoassay in 79% of the patients studied, including 60% of the children 1 yr or less in age. The intensity of antibody response although clearly related to the age of the patient, was more reliably predicted by the efficiency of antigen clearance. Antibody responses were uniformly of low magnitude in patients with prolonged antigenemia, irrespective of age. Paients who failed to develop antibody to polyribophosphate after meningitis also exhibited impaired antigen clearance. These studies suggest that mechanisms necessary for clearance of polyribophosphate may influence

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“…If this ex perimental model were to apply to man, hemolytic anemia or tissue injury on an immunologic basis may develop through the mechanism of attachment of bacterial antigen to the host cells and may be mediated by the corresponding bacterial antibodies. Indeed, Y oung et al (30) have reported that in vivo antigenic modification does take place in infants with enterobacterial enteritis. Finally, so far as protection is concerned, it has been shown that antibodies against CA (-), e.g.…”

Section: Discussionmentioning

confidence: 99%