Sensitization of the thymus to hypoplastic effect of glucocorticoids after long-term hypokinetic stress

We studied the cell composition and free radical oxidation in the bone marrow of white outbred rats after hypokinetic stress (24 and 72 h) and the effects of exogenous glucocorticoid triamcinolone acetonide (2 mg/kg; injected 24 h after hypokinesia); the measurements were performed in 96 h after drug administration. The hypoplastic effect of the glucocorticoid after 24-h hypokinesia was observed against the background of reduced free radical oxidation. In animals subjected to 3-day hypokinesia, the resistance of the bone marrow to the hypoplastic effect of this drug was accompanied by activation of free radical processes.

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Effects of Preliminary Hypokinetic Stress on Sensitivity of the Bone Marrow to the Hypoplastic Effect of Exogenous Glucocorticoid

Tseĭlikman

Осиков

Strel'nikova

et al. 2013

Bull Exp Biol Med

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Sensitization of the thymus to hypoplastic effect of glucocorticoids after long-term hypokinetic stress

Abstract: Long-term hypokinesia increases sensitivity of the thymus to the hypoplastic effect of glucocorticoid preparation triamcinolone acetonide by potentiating the proapoptotic effect of the glucocorticoid.

Cited by 1 publication

References 5 publications

Effects of Preliminary Hypokinetic Stress on Sensitivity of the Bone Marrow to the Hypoplastic Effect of Exogenous Glucocorticoid

Effects of Preliminary Hypokinetic Stress on Sensitivity of the Bone Marrow to the Hypoplastic Effect of Exogenous Glucocorticoid

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