Sensitization to 1,3‐diphenylguanidine: An underestimated problem in physicians and nurses using surgical gloves?

Hansen, Andreas; Buse, Anna‐Sophie; Wilke, Annika; Skudlik, Christoph; John, Swen Malte; Brans, Richard

doi:10.1111/cod.13713

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…Due to an increasing share of (sterile) medical disposable gloves made of chloroprene/polyisoprene, the sensitization rate has increased in certain medical fields [ 1 ]. This is illustrated by publications from Belgium [ 7 ] and Sweden [ 17 ] as well as a recent case series from Germany [ 11 ]. However, patch test reactions to DPG have to be interpreted with caution as it belongs to the so-called “problem allergens” due to its irritant properties, and accordingly false-positive test reactions must be considered [ 9 ].…”

Section: Contact Allergy To Rubber Acceleratorsmentioning

confidence: 97%

“…Guanidines, especially 1,3-diphenylguanidine (DPG), are used for example in (poly)chloroprene/isoprene and butyl gloves. Recently, increased cases of contact allergy to DPG have been reported in connection with (sterile) disposable medical gloves made of chloroprene/polyisoprene [ 7 , 11 , 17 ]. An experimental study showed that alcohol-based hand disinfectants, which are applied prior to the donning of sterile protective gloves, increase the release of DPG from the glove material [ 10 ].…”

Section: Challenge and Possible Solutions For Glove Selectionmentioning

confidence: 99%

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Allergic contact dermatitis to rubber accelerators in protective gloves: Problems, challenges, and solutions for occupational skin protection

Hansen

Brans

Sonsmann

2021

ALS

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Protective gloves are an elementary component of personal protective equipment in many occupations and are intended to protect the hands from various hazards (e.g., wetness, chemicals, mechanical forces, or thermal stress). This is particularly important when other occupational safety measures (e.g., technical-organizational measures) cannot be implemented or are insufficient. However, it is not uncommon for protective gloves themselves to become a problem, as some of their ingredients (e.g., rubber accelerators) can cause allergic reactions. Accelerators in rubber gloves include thiurams, dithiocarbamates, thiazoles, guanidines, and thioureas. If no alternative means of protection are available, this may even result in abandoning the profession. This article is about rubber accelerators, which are often contained in protective gloves made of different rubber materials (e.g., natural rubber (latex) and nitrile rubber) and may cause delayed-type allergies, as well as related challenges, problems, and solutions for occupational skin protection.

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Section: Contact Allergy To Rubber Acceleratorsmentioning

confidence: 97%

Section: Challenge and Possible Solutions For Glove Selectionmentioning

confidence: 99%

Allergic contact dermatitis to rubber accelerators in protective gloves: Problems, challenges, and solutions for occupational skin protection

Hansen

Brans

Sonsmann

2021

ALS

Self Cite

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“…Gloves continue to be a source of known allergens related to rubber accelerators and also newly described allergens. These include 1,3-diphenylguanidine (DPG), benzisothiazolinone and cetylpyridinium chloride (CPC, an antimicrobial agent that coats the inside of some surgical gloves) [47,48]. These should be patch tested in healthcare workers with hand dermatitis who use sterile surgical gloves if available.…”

Section: Preventive Equipment and Products Amplified By Covid-19mentioning

confidence: 99%

New causes of occupational allergic contact dermatitis

Clynick,

Holness

2023

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Occupational allergic contact dermatitis (OACD) is an important work-related skin disease. Information about the causative agents comes from many sources, including patch test databases, registries, case series and case reports. This review summarizes new information about common causative allergens and diagnosis. Recent findings Common causes of OACD include rubber components, epoxies and preservatives. New exposure sources for these allergens continue to be described. Often these exposure sources are related to the changing world around us, such as allergens related to smartphones and technology, and personal protective equipment-related exposures during the COVID-19 pandemic. New allergens are also being described, some of which are related to known allergens (e.g. a new epoxy or acrylate component). Accurate diagnosis is critical to effective management of OACD, which may include removing the worker from exposure to the causative allergen. Safety data sheets may not contain complete information and patch testing with specialized series of allergens and workplace materials may be necessary. Summary This review provides current evidence about causes of OACD and important aspects of diagnosis. This is important for clinical practice to ensure cases of OACD are not missed.

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“…DDAC ACD + Feet, lower legs [ 26 ] Cetrimonium Bromide (CTAB) Preservatives containing 0.5% pet. CTAB (ie facial cleansers, cosmetics, skin lighting creams, and hair conditioning agents) PCD/ACD + Face, neck, scalp, upper back, fingers, earlobes, arm, forearm [ 27 ] Cetrimide 3% cetrimide antiseptic solution ICD + Neck, groin, scrotum, flexor sites [ 28 ] Antiseptic solution containing 0.1% cetrimide ACD + Scrotum, Penile skin [ 29 ] Kumkum, Hair dye, and Lipstick and Solution containing 0.5% cetrimide ACD + Face, scalp, arms, forearms, trunk, feet [ 30 ] Shampoo containing 12% cetrimide solution ACD + Chest [ 31 ] Gypsona ® (Plaster of Paris) containing 0.5% cetrimide ACD + Lower arm, forearm, hand [ 32 ] Cetylpyridinium Chloride (CPC) Cetylpyridinium chloride 0.1% ACD + N/A [ 33 ] Protexis™ PI polyisoprene sterile surgical gloves with CPC inner coating ACD + Hand [ 34 ] …”

Section: Introductionmentioning

confidence: 99%

Quaternary Ammonium Compounds and Contact Dermatitis: A Review and Considerations During the COVID-19 Pandemic

Okeke¹,

Khanna²,

Ehrlich³

2023

CCID

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The recent global pandemic has resulted in increased use of quaternary ammonium compounds (QACs). Currently, QACs are active ingredients in 292 disinfectants recommended by the US EPA for use against SARS-CoV-2. Among QACs, benzalkonium chloride (BAK), cetrimonium bromide (CTAB), cetrimonium chloride (CTAC), didecyldimethylammonium chloride (DDAC), cetrimide, quaternium-15, cetylpyridinium chloride (CPC), and benzethonium chloride (BEC) were all identified as potential culprits of skin sensitivity. Given their widespread utilization, additional research is needed to better classify their dermal effects and identify other cross-reactors. In this review, we aimed to expand our knowledge about these QACs to further dissect its potential allergic and irritant dermal effects on healthcare workers during COVID-19.

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Sensitization to 1,3‐diphenylguanidine: An underestimated problem in physicians and nurses using surgical gloves?

Cited by 6 publications

References 5 publications

Allergic contact dermatitis to rubber accelerators in protective gloves: Problems, challenges, and solutions for occupational skin protection

Allergic contact dermatitis to rubber accelerators in protective gloves: Problems, challenges, and solutions for occupational skin protection

New causes of occupational allergic contact dermatitis

Quaternary Ammonium Compounds and Contact Dermatitis: A Review and Considerations During the COVID-19 Pandemic

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