Sensitization to cross‐reactive carbohydrate determinants in relation to alcohol consumption

Gonzalez-Quintela, Arturo; Garrido, M.; Gudé, Francisco; Campos, Joaquín; Linneberg, Allan; Lojo, S.; Vidal, Carmen

doi:10.1111/j.1365-2222.2007.02863.x

Cited by 34 publications

(58 citation statements)

References 40 publications

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“…This is in line with findings of 2 studies from the northwestern part of the Iberian peninsula (parts of Spain [9] and Portugal [8]). Thus, the association between alcohol and CCD sensitization seems to be universal and independent of cultural (e.g.…”

Section: Discussionsupporting

confidence: 79%

“…The factors that increase the risk of CCD sensitization are not entirely known [2]. CCD sensitization has been found to be associated with alcohol consumption in studies in the regions of Spain and Portugal in the northwest of the Iberian peninsula, where wine is the preferred alcoholic beverage by far [8,9]. It is not known whether the association between alcohol and CCD sensitization is present in other regions with different climatic and environmental conditions as well as different patterns of alcohol drinking.…”

Section: Introductionmentioning

confidence: 99%

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Immunoglobulin E Sensitization to Cross-Reactive Carbohydrate Determinants: Epidemiological Study of Clinical Relevance and Role of Alcohol Consumption

Linneberg¹,

Fenger²,

Husemoen³

et al. 2010

Int Arch Allergy Immunol

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Background: The determinants and biologic significance of IgE-mediated sensitization to cross-reactive carbohydrate determinants (CCDs) are not entirely known. An association between alcohol consumption and CCD sensitization has been reported in studies from Spain and Portugal. Objective: To investigate the relationship of alcohol consumption with CCD sensitization, the role of alcohol dehydrogenase gene polymorphisms, and the clinical consequences of CCD sensitization. Methods: Serum-specific IgE sensitization (≧0.1 kU/l) to a CCD (the N-glycan from bromelain) was assessed in 1,197 adults participating in a population-based study in Copenhagen, Denmark. Alcohol consumption and atopic symptoms (rhinitis, asthma and oral allergy syndrome) were assessed by questionnaire. Examinations included skin prick tests (SPTs), qualitative multiallergen IgE test (Phadiatop®), methacholine bronchial hyperreactivity, eosinophil cationic protein and alcohol dehydrogenase (ADH) gene polymorphisms. Results: Alcohol consumption was significantly associated with CCD sensitization and this was particularly evident in SPT-negative individuals. The fast-metabolizing allele of the ADH1b polymorphism was significantly associated with CCD sensitization in alcohol drinkers. CCD sensitization was associated with atopic symptoms, but associations attenuated markedly when adjusting for SPT reactivity. Conclusions: Our results suggest that the positive association between alcohol consumption and CCD sensitization is universal and not specific to certain populations. The observed association between the ADH1b polymorphism and CCD sensitization may support that alcohol is causally related to the risk of CCD sensitization. The observed association between CCD sensitization and atopic phenotypes did not appear to be independent of SPT reactivity indicating limited significance of CCD sensitization per se.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Immunoglobulin E Sensitization to Cross-Reactive Carbohydrate Determinants: Epidemiological Study of Clinical Relevance and Role of Alcohol Consumption

Linneberg¹,

Fenger²,

Husemoen³

et al. 2010

Int Arch Allergy Immunol

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“…McMillan et al on the other hand, found a decrease in IgG and IgM and an increase in IgA levels in alcoholics and smokers [25]. There are other studies also in which statistically significant increase in IgA was associated with alcohol abuse [5,23,26]. In the present study though IgA levels were increased, however, to find out its statistical significance large number of cases need to be studied.…”

Section: Resultscontrasting

confidence: 49%

“…A recent Korean study showed an increased prevalence of allergic sensitization to house dust mite in alcoholics [20]. There are few other studies also suggesting an association between increased IgE and allergic sensitization in alcoholics [22][23][24]. In control subjects who showed high total IgE levels (>500 IU/ml), specific IgE levels were measured against common allergens (house dust, tree, and food allergens) to detect an allergic component.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Serum Immunoglobulins IgG, IgA, IgM and Total IgE in Chronic Alcoholics: A Community-based Study

Kumar¹

2015

Immunochem Immunopathol

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Long-term intake of alcohol affects virtually every organ in the body including the immune system. The relation between alcohol abuse and immunoglobulin production has not been studied in Indian population. Serum levels of immunoglobulins (total IgE, IgG, IgM, and IgA) therefore, were analyzed in adult chronic alcoholics and were correlated with different epidemiological and alcohol-related parameters. The results showed that 98% of alcoholics had abnormal immunoglobulin levels and 92% showed high or very high total serum IgE levels compared to 24% of the control group. Long term and moderate consumption of alcohol were also associated with frequent infections. Serum immunoglobulin assay including total IgE may be helpful in screening and assessment of chronicity of alcohol abuse.

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“…Due to the lack of information on allergic disease at baseline (in 1976–1978), we cannot investigate the role of alcohol in the development of new (incident) allergic disease. We have recently shown that persons who drink moderate to large amounts of alcohol have a significantly increased prevalence of IgE sensitization to cross-reactive carbohydrate determinants (CCDs) [28, 29]. In these studies, serum-specific IgE sensitization to CCDs was associated with false-positive serum-specific IgE sensitization to CCD-bearing allergens, such as pollens and latex.…”

Section: Discussionmentioning

confidence: 94%

Incidence and Remission of Specific IgE Aeroallergen Sensitization from Age of 40 to 60 Years, and Association with Alcohol Consumption

Linneberg¹,

Friedrich²,

Husemoen³

et al. 2009

Int Arch Allergy Immunol

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Background: Data on incidence and long-term persistence of IgE aeroallergen sensitization in older adults are limited. Alcohol consumption is a strong immune-modulator with a significant impact on the IgE response. Objectives: We aimed to assess the incidence and remission of aeroallergen sensitization from the age of 40 to 60 years. Furthermore, we examined the relationship of alcohol consumption to the prevalence and incidence of aeroallergen sensitization. Methods: In 1976–1977, a total of 1,200 people born in 1936 and randomly selected from the general population were invited for a health examination (1,052 were examined). At 60 years, they were invited for a re-examination (695 were examined). Stored serum samples from both examinations were analyzed consecutively for serum-specific IgE to aeroallergens by using a qualitative multi-allergen immunoassay. Results: We observed a total of 32 (7.1% of those not sensitized at 40 years) incident cases and 35 (41.1% of those sensitized at 40 years) remittent cases of aeroallergen sensitization over this 20 year period. Persistent as well as incident sensitization was significantly associated with self-reported atopic disease at 60 years. Alcohol consumption (>14 drinks per week) at 40 years was significantly associated with a higher prevalence of sensitization at 40 years, but not with the incidence of sensitization. Conclusions: In older adults, aeroallergen sensitization as reflected by serum-specific IgE positivity to aeroallergens is a dynamic process. Both persistent and incident sensitization was associated with atopic disease. Further studies are needed to clarify the influence of alcohol on the allergen-specific IgE response.

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Sensitization to cross‐reactive carbohydrate determinants in relation to alcohol consumption

Abstract: CCD-specific IgE is prevalent in heavy drinkers, and is associated with positive IgE to pollens and Hymenoptera venoms. Specific IgE results should be interpreted with caution in heavy drinkers.

Cited by 34 publications

References 40 publications

Immunoglobulin E Sensitization to Cross-Reactive Carbohydrate Determinants: Epidemiological Study of Clinical Relevance and Role of Alcohol Consumption

Immunoglobulin E Sensitization to Cross-Reactive Carbohydrate Determinants: Epidemiological Study of Clinical Relevance and Role of Alcohol Consumption

Evaluation of Serum Immunoglobulins IgG, IgA, IgM and Total IgE in Chronic Alcoholics: A Community-based Study

Incidence and Remission of Specific IgE Aeroallergen Sensitization from Age of 40 to 60 Years, and Association with Alcohol Consumption

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