Sensitization to food and airborne allergens in children with atopic dermatitis followed up to 7 years of age

Gustafsson, Dan; Sjöberg, Olof; Foucard, Tony

doi:10.1046/j.0905-6157.2003.00093.x

Cited by 57 publications

(37 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Remaining sensitization to egg at 4.5 years of age was associated with both ARC and asthma development, confirming several other studies [37], [42]. In early childhood, sensitization to hen's egg has been associated with sensitization to airborne allergens [43]. At the age of 10 we found no correlation for egg sensitization, ARC and asthma.…”

Section: Discussionsupporting

confidence: 89%

Severe Eczema in Infancy Can Predict Asthma Development. A Prospective Study to the Age of 10 Years

Ekbäck

Tedner²,

Devenney

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

BackgroundChildren with atopic eczema in infancy often develop allergic rhinoconjunctivitis and asthma, but the term “atopic march” has been questioned as the relations between atopic disorders seem more complicated than one condition progressing into another.ObjectiveIn this prospective multicenter study we followed children with eczema from infancy to the age of 10 years focusing on sensitization to allergens, severity of eczema and development of allergic airway symptoms at 4.5 and 10 years of age.MethodsOn inclusion, 123 children were examined. Hanifin-Rajka criteria and SCORAD index were used to describe the eczema. Episodes of wheezing were registered, skin prick tests and IgE tests were conducted and questionnaires were filled out. Procedures were repeated at 4.5 and 10 years of age with additional examinations for ARC and asthma.Results94 out of 123 completed the entire study. High SCORAD points on inclusion were correlated with the risk of developing ARC, (B = 9.86, P = 0.01) and asthma, (B = 10.17, P = 0.01). For infants with eczema and wheezing at the first visit, the OR for developing asthma was 4.05(P = 0.01). ARC at 4.5 years of age resulted in an OR of 11.28(P = 0.00) for asthma development at 10 years.ConclusionThis study indicates that infant eczema with high SCORAD points is associated with an increased risk of asthma at 10 years of age. Children with eczema and wheezing episodes during infancy are more likely to develop asthma than are infants with eczema alone. Eczema in infancy combined with early onset of ARC seems to indicate a more severe allergic disease, which often leads to asthma development. The progression from eczema in infancy to ARC at an early age and asthma later in childhood shown in this study supports the relevance of the term “atopic march”, at least in more severe allergic disease.

show abstract

Section: Discussionsupporting

confidence: 89%

Severe Eczema in Infancy Can Predict Asthma Development. A Prospective Study to the Age of 10 Years

Ekbäck

Tedner²,

Devenney

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…4,15 Sensitization to hen's egg is a strong predictor of later atopy 16,17 ; we showed that a positive SPT response with hen's egg at the time of diagnosis predicted the persistence of CMA. In addition, early exposure to CM was related to delayed development of tolerance to CM.…”

Section: Discussionmentioning

confidence: 90%

Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status

Saarinen

Pelkonen

Mäkelä

et al. 2005

Journal of Allergy and Clinical Immunology

264

229

View full text Add to dashboard Cite

“…Children with atopic dermatitis were followed-up regularly from infancy to age 7 to look at the risk factors for sensitization to food and airborne allergens [76]. In this cohort, reactions to milk and eggs (as documented by positive skin tests) were transient but reactivity to peanuts was persistent.…”

Section: Atopic Dermatitismentioning

confidence: 99%

Food Allergy Overview in Children

Ramesh

2007

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Food allergies have increased significantly in the past decade. An accurate history is crucial in approaching the management. At the outset, food intolerance must be distinguished from food allergies and, furthermore, these allergies should be classified into either an IgE, Non-IgE, or a mixed response. The clinical features vary from life-threatening anaphylaxis to milder IgE-mediated responses, atopic dermatitis, and gastrointestinal symptoms. The severity of the reaction and the potential risk for anaphylaxis on reexposure should be assessed. Milk, soy, egg, wheat, and peanut allergies are common in children, whereas peanut, tree nut, fish, shell fish allergies, and allergies to fruits and vegetables are common in adults. Structural proteins are important determinants of the severity of the reactions and may often predict the natural history and cross reactivity. Diagnostic work up must be guided by the clinical history. Skin testing and food-specific IgE done by standard methods are very useful, whereas oral challenges may be indicated in some situations. Majority of the patients outgrow their allergies to milk, soy, egg, and wheat, and some to peanut also, therefore, patients should be periodically reassessed. Novel diagnostic techniques which detect specific allergenic epitopes have been developed. Several newer therapies are promising.

show abstract

Sensitization to food and airborne allergens in children with atopic dermatitis followed up to 7 years of age

Cited by 57 publications

References 30 publications

Severe Eczema in Infancy Can Predict Asthma Development. A Prospective Study to the Age of 10 Years

Severe Eczema in Infancy Can Predict Asthma Development. A Prospective Study to the Age of 10 Years

Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status

Food Allergy Overview in Children

Contact Info

Product

Resources

About