Sensitization to Gibberellin-Regulated Protein (Peamaclein) Among Italian Cypress Pollen–Sensitized Patients

Asero, Riccardo; Abbadessa, S; Aruanno, Arianna; Barilaro, Giuseppe; Bignardi, Donatella; Bilò, Maria Beatrice; Borro, Matteo; Bresciani, M; Busa, Moira; Buzzulini, Francesca; Cavaliere, Carlo; Cecchi, Lorenzo; Ciccarelli, A; Cortellini, Gabriele; Cucinelli, Francesco; Deleonardi, Gaia; Emiliani, F; Farsi, Alessandro; Ferrarini, E; Franchini, Maurizio; Ingrassia, A.; Lippolis, D; Losappio, Laura; Marra, Alessandro Maria; Martini, Matteo; Masieri, Simonetta; Mauro, Maria Gaetana Di; Mazzolini, M; Muratore, L.; Murzilli, F; Nucera, Eleonora; Pastorello, Elide A.; Pinter, Elena; Polillo, Battista Roberto; Pravettoni, Valerio; Quercia, O; Rizzi, Angela; Russello, Marina; Sacerdoti, Carlo; Scala, Enrico; Scala, Giovanni; Scarpa, Alessandro; Schroeder, Jan Walter; Uasuf, Carina Gabriela; Villalta, Danilo; Yang, Bei-Chang; Mistrello, Gianni; Amato, Stefano; Lidholm, Jonas

doi:10.18176/jiaci.0542

Cited by 17 publications

(17 citation statements)

References 26 publications

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“…21 The exact role of cypress pollen in relation to PFAS is yet unknown and subject of current research. [22][23][24][25] Pollen food allergy syndrome cross-reactions are caused by plant-food allergens that share sequence, structure, and function similarities with pollen allergens. Due to their widespread nature, these are known as panallergens.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study

Lipp

Şahin

Aggelidis

et al. 2021

Allergy

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Section: Introductionmentioning

confidence: 99%

“…One of these is cypress pollen, a primary cause of SAR in the Mediterranean 21 . The exact role of cypress pollen in relation to PFAS is yet unknown and subject of current research 22‐25 …”

Section: Introductionmentioning

confidence: 99%

Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study

Lipp

Şahin

Aggelidis

et al. 2021

Allergy

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“…The researchers from France described the peach GRP as a major allergen in the patients allergic to peach from southern France, where the exposure to cypress pollen is high, with a prevalence of Pru p 7 sensitization exceeding 60% (9,28). In contrast, a recent study reported that the allergy and sensitization to foods secondary to cypress pollen allergy appeared as rare phenomenon in the Italian population and that most of such patients react to peach, rather than other Rosaceae fruits (29). Therefore, discrepant results concerning the allergenic properties of GRP can sometimes be found in the literature.…”

Section: Discussionmentioning

confidence: 99%

When the Frequencies of Sensitization and Elicitation of Allergic Reaction Do Not Correlate—The Case of Apple Gibberellin-Regulated Protein Tested in an Italian Population

Tuppo

Alessandri²,

Giangrieco

et al. 2021

Front. Allergy

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Background: The literature reports describing allergic symptoms against apples in the patients sensitized to the gibberellin-regulated proteins (GRPs) suggested the presence of an allergenic GRP in this fruit.Objective: This study aimed to assess the presence of a GRP protein in apples and investigate its allergenicity.Methods: The protein was isolated and identified by the classical biochemical methods. The bioinformatics tools were used for similar searches and molecular modeling. The immunological features were investigated using the multiplex FABER test. Clinical data were collected by the allergy specialists.Results: A GRP was detected in the apple peel and pulp and it was named applemaclein. This protein displays 94% of sequence identity with peamaclein, Pru p 7, representing the prototype of this allergen family. The applemaclein molecular model shows a very irregular surface with grooves/clefts that may potentially accommodate small molecular ligands. In a population of 4,721 patients in Italy, 187 (4.0%) were sensitized to any allergenic GPR. Of those, 115 (61.5%), 61 (32.6%), 30 (16.0%), and 99 (52.9%) had immunoglobulin E (IgE) to apple, peach, pomegranate, and cypress GRP, respectively. However, in a cohort of the patients in Italy, most individuals IgE positive to the apple GRP did not report allergic reactions against this fruit.Conclusion: Compared with the peach Pru p 7, applemaclein shows some different structural features and higher sensitization frequency, which is often not associated with allergic reactions against apple. Further studies are needed to understand a possible correlation between the applemaclein structural properties, the interaction with still unknown molecules, and immunological behavior.

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“…Based on its geographic distribution, cypress pollen is another putative candidate as a primary sensitizer to lipid transfer protein (328). Nowadays we know that cypress pollen is the primary sensitizer to gibberellin-regulated protein, which is associated with systemic reactions to different fruits, particularly the peach (33,34). To our knowledge, there are no data regarding an association with food LTP hypersensitivity and besides, no LTPs have been identified in cypress pollen so far…”

Section: Cypress (Cupressus Arizonica)mentioning

confidence: 99%

Why lipid transfer protein allergy is not a pollen-food syndrome: novel data and literature review

Asero

Brusca

Cecchi

et al. 2022

Eur Ann Allergy Clin Immunol

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BACKGROUND: Based on the cross-reactivity between pollen lipid transfer proteins (LTPs) and the peach LTP, Pru p 3, it has been suggested that the pollen might initiate the LTP sensitization process.OBJECTIVE: To establish whether LTP allergy can be considered as a pollen-food syndrome. METHODS:The literature was reviewed and new data of component-resolved diagnosis from Italy obtained by both ISAC immunoassay and ImmunoCAP on large populations of LTP hypersensitive patients were provided and analyzed.RESULTS: Among Pru p 3 reactors, patients positive for Art v 3 and Pla a 3 largely exceeded those sensitized to the respective major pollen allergens, Art v 1 and Pla a 1/Pla a 2. Pru p 3 reactivity remained stable around 80-90% at all ages, whereas Art v 3 and Ole e 7 recognition was missing in younger patients. Pru p 3 IgE exceeded IgE specific for pollen LTP at all ages. Inhibition studies carried out on LTP reactors showed that commercial extracts of mugwort and plane pollen were unable to inhibit significantly Pru p 3 IgE reactivity. In follow-up studies, baseline Pru p 3 IgE levels exceeded Art v 3 IgE levels in 84% of those sensitized to both allergens, and all patients positive to only one LTP allergen at baseline were sensitized to Pru p 3. Further, most of the patients who did not show any LTP reactivity at baseline became exclusive Pru p 3 reactors. On ImmunoCAP singleplex Pru p 3 IgE levels exceeded Art v 3 IgE levels in 89% of cases (p< 0.0001). Most literature data were in keeping with these new observations. CONCLUSION: The evidence for LTP syndrome being a pollen-food syndrome is presently very thin.Our data do not rule out the possible sensitization to the protein, via the airways or the skin.

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Sensitization to Gibberellin-Regulated Protein (Peamaclein) Among Italian Cypress Pollen–Sensitized Patients

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, types etting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 17 publications

References 26 publications

Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study

Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study

When the Frequencies of Sensitization and Elicitation of Allergic Reaction Do Not Correlate—The Case of Apple Gibberellin-Regulated Protein Tested in an Italian Population

Why lipid transfer protein allergy is not a pollen-food syndrome: novel data and literature review

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