Sensitization to <i>Hymenoptera</i> venom marker allergens: Prevalence, predisposing factors, and clinical implications

Stoevesandt, Johanna; Hosp, Christine; Kerstan, Andreas; Trautmann, Axel

doi:10.1111/cea.13237

Cited by 12 publications

(11 citation statements)

References 32 publications

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“…to Hymenoptera venoms. High sensitization rates to Hymenoptera venoms in asymptomatic subjects have been described [2,3,9]. IgE antibodies to CCD were found primarily in individuals with double sensitization to bee and wasp venoms as shown in previous studies [9].…”

Section: Plos Onementioning

confidence: 62%

“…In our study almost half (45.7%) of the symptomatic pollen allergic patients and 26.7% of the non-atopic controls without history of a systemic reaction after a Hymenoptera sting had sIgE to Hymenoptera venoms. High sensitization rates to Hymenoptera venoms in asymptomatic subjects have been described [ 2 , 3 , 9 ]. IgE antibodies to CCD were found primarily in individuals with double sensitization to bee and wasp venoms as shown in previous studies [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…High sensitization rates to Hymenoptera venoms in asymptomatic subjects have been described [ 2 , 3 , 9 ]. IgE antibodies to CCD were found primarily in individuals with double sensitization to bee and wasp venoms as shown in previous studies [ 9 ]. Almost three quarters of all persons with sensitization to bee and wasp venom also had sIgE to CCDs (17/23, 73.9%).…”

Section: Discussionmentioning

confidence: 99%

“…They are thought to be responsible for cross-reactivity between potential allergens with negative impact on the correct diagnosis of allergies. This mechanism is primarily involved in persons with double sensitization to bee and wasp venom [ 9 ] and/or with polysensitization to pollen allergens [ 10 – 12 ]. Although atopy is not a risk factor for Hymenoptera venom allergy, the occurrence of high total IgE (t-IgE) or sIgE to pollen allergens is associated with an increased rate of sensitization to bee or wasp venom [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Sensitization to Hymenoptera venom in pollen allergic patients: Frequency and involvement of cross-reacting carbohydrate determinants (CCD)

et al. 2020

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Sensitization to Hymenoptera venom in patients without a history of systemic allergic reactions to Hymenoptera stings is frequently found and can be due to the presence of specific IgE to cross-reactive carbohydrate determinants (CCD). This study investigates 105 pollen allergic subjects for the presence of specific IgE to honeybee or wasp venom, pollen, the MUXF3 carbohydrate epitope from bromelain and recombinant Hymenoptera venom components. In addition, in a subgroup of patients (n = 10) a basophil activation test (BAT) using bee and wasp venom was performed. Specific IgE to Hymenoptera venom was detected in 45.7% of the pollen allergic subjects and in 26.7% of the non-atopic controls, both without a history of systemic allergic reactions to Hymenoptera stings. The high sensitization rate in atopic patients could partially be explained by cross-sensitization between pollen and Hymenoptera venom due to specific IgE to CCDs. In our study population, only 20% showed a sensitization to CCDs. Primary sensitization due to sting exposure, high total IgE values or unspecific binding and detection of low affinity antibodies in the test procedure could be reasons. Thus, determination of specific IgE to Hymenoptera venom in patients without a history of systemic allergic reactions as screening test is not recommended.

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Section: Plos Onementioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sensitization to Hymenoptera venom in pollen allergic patients: Frequency and involvement of cross-reacting carbohydrate determinants (CCD)

et al. 2020

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“…Lastly in this issue of the Journal, Stoevesandt et al look at the sensitization profile of 490 dermatology patients without a history of sting‐induced anaphylactic reactions . The vast majority of the individuals had a Hymenoptera sting.…”

mentioning

confidence: 99%

Diagnostic and other challenges

Roberts

2018

Clin Experimental Allergy

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It was good to see so many colleagues at the EAACI Food Allergy and Anaphylaxis Meeting (FAAM) in Copenhagen in October. Once again, the meeting managed to effectively mix the wide range of stakeholders involved in food allergy. It was a really good fertile environment to promote the interdisciplinary work that is needed to progress the agenda for our patients. November saw the first meeting of the EAACI Prevention Guideline Task Force where the protocol for the revision of the guidelines was discussed and agreed. This marks the start of the revision of the 2014 Food Allergy and Anaphylaxis Guidelines; the aim is to also start the revision of anaphylaxis and food allergy in 2019. The new advances showcased at the Caption to cover illustration: The cover image is based on the Original Article Monocytes accumulate in the airways of children with fatal asthma by Ibon Eguíluz-Gracia et al, DOI: https://doi. /journal/cea Clin Exp Allergy. 2018;48:1582-1583. patient management. Courbis et al describe the generation of a clinical decision support system (CDSS) for allergic rhinitis using expert consensus. 3 The CDSS is integrated into the Allergy Diary Companion which is designed to be used during patient-physician consultations. Symptom information collected as a visual analogue score (VAS) in the diary would be used to direct management using the CDSS (Figure 2). We now need to see how the system operates in practice and whether it improves patient outcomes. Lastly in this issue of the Journal, Stoevesandt et al look at the sensitization profile of 490 dermatology patients without a history of sting-induced anaphylactic reactions. 4 The vast majority of the individuals had a Hymenoptera sting. The percentage with sensitization to each of the components were 17.3% for rVes v 1, 18.0% for rVes v 5 and 3.5% for rApi m 1 (0.35 kU/L cut off) (Figure 3). So there is a relatively high prevalence of asymptomatic sensitization which needs to be considered when interpreting venom allergic sensitization results. 5

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Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA)

Pascal

Moreno‐Aguilar

Dávila

et al. 2021

Clinical & Translational All

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The introduction of molecular diagnosis into routine clinical practice has substantially improved the diagnosis and management of allergic patients by allowing clinicians to precisely identify the allergenic molecule responsible for immunoglobulin E (IgE)‐mediated allergies. However, it can be challenging to accurately interpret the results of molecular assays, partly due to the limited evidence base. In this context, a panel of experts with extensive experience in interpreting in vitro measures of total and serum specific IgE reviewed the available scientific evidence. After this review, the panel selected a series of representative case studies to demonstrate how determination of specific and total IgE values and the relationship between them (ratio analysis) can add value to the diagnostic process by more precisely defining the patient’s sensitization profile. Finally, the experts developed a series of recommendations on the clinical application of ratio analysis to optimize and complement the classical approach to allergy diagnosis.

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Sensitization to Hymenoptera venom marker allergens: Prevalence, predisposing factors, and clinical implications

Cited by 12 publications

References 32 publications

Sensitization to Hymenoptera venom in pollen allergic patients: Frequency and involvement of cross-reacting carbohydrate determinants (CCD)

Sensitization to Hymenoptera venom in pollen allergic patients: Frequency and involvement of cross-reacting carbohydrate determinants (CCD)

Diagnostic and other challenges

Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA)

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