Sensitization to Kathon CG in Switzerland: Report of the Swiss Contact Dermatitis Research Group

Hunziker, N; Pasche, Florence; Bruckner-Tuderman, L; Perrenoud, D.; Rufli, R.; Bircher, A. J.; Suter, Hans; Thürliman, W.

doi:10.1007/978-3-642-74299-6_22

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…The rate of sensitiza tion to (chlor)methylisothiazolinone seems to be generally increasing, probably mirroring the progressive usage of this chemical as a preservative. In 1987. the overall prevalence in Switzerland was 3.5%, and in our institution 2.5% [ 14], In the present evaluation, the rate was 4.7%. However, a clearly more common sensitization could be observed in women with eczema of the hands.…”

Section: Discussionsupporting

confidence: 48%

Patch Test Results of the Dermatology Clinic Zurich in 1989: Personal Computer-Aided Statistical Evaluation

Bruckner-Tuderman¹,

König²,

Schnyder³

1992

Dermatology

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The patch test results of 921 consecutively tested patients were registered on an IBM personal computer. A computer program based on the dBase III plus database software, especially designed for this purpose, was used. The statistical evaluation was performed with dBase III plus. 59% of the probands were females and 41% males. The average age was 42.8 years. 26% of the probands were inpatients and 74% outpatients. A majority of the patients presented with eczema of the hands, face or the lower legs. The largest occupational groups were houseworkers and cleaning personnel, office workers and pensioners. To 450 of the 921 patients, at least 4 test series were applied simultaneously. These included European standard, vehicles and emulgators, topical medications, and preservatives and biocides. The other 20 test series available were employed only by 2-81 patients each. The highest sensitization rates were found with: nickel, 18.7%; cobalt, 10.2%; balsam of Peru, 8.8%; framycetin, 8.0%; neomycin, 6.8%; potassium dichromate, 6.1%; p-phenylene diamine, 5.4%; paramix, 4.9%; formaldehyde, 4.8%, and (chlor)methylisothiazolinone, 4.7%. The critical evaluation of the data showed two kinds of problems: first, test-specific aspects led to optimization of the patch test procedures; second, the crucial importance of an adequate statistical analysis for epidemiological investigation was revealed.

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Section: Discussionsupporting

confidence: 48%

Patch Test Results of the Dermatology Clinic Zurich in 1989: Personal Computer-Aided Statistical Evaluation

Bruckner-Tuderman¹,

König²,

Schnyder³

1992

Dermatology

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5‐Chlor‐2‐methyl‐2,3‐dihydroisothiazol‐3‐on und 2‐Methyl‐2,3‐dihydroisothiazol‐3‐on [MAK Value Documentation in German language, 1991]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 17. Lieferung, Ausgabe 1991 Der Artikel enthält folgende Kapitel: Besondere Hinweise Allgemeiner Wirkungscharakter Angaben zur Pharmakokinetik Erfahrungen beim Menschen Tierexperimentelle Untersuchungen Akute toxische Wirkungen Subakute und subchronische Wirkungen Allergene Wirkung Reproduktions‐ und Teratogenitätsstudien Untersuchungen zur gentoxischen Wirkung Untersuchungen zur kanzerogenen Wirkung Bewertung Begründung des MAK‐Wertes

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5‐Chloro‐2‐methyl‐2,3‐dihydroisothiazol‐3‐one and 2‐Methyl‐2,3‐dihydroisothiazol‐3‐one [MAK Value Documentation, 1993]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 5 (1993) The article contains sections titled: Note Toxic Effects and Modes of Action Pharmacokinetics Effects in Man Effects on Animals Acute toxicity Subacute and subchronic toxicity Allergenic Effects Reproductive and Developmental Toxicity Genotoxicity Carcinogenicity Manifesto (MAK value, classification)

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Sensitization to Kathon CG in Switzerland: Report of the Swiss Contact Dermatitis Research Group

Cited by 5 publications

References 9 publications

Patch Test Results of the Dermatology Clinic Zurich in 1989: Personal Computer-Aided Statistical Evaluation

Patch Test Results of the Dermatology Clinic Zurich in 1989: Personal Computer-Aided Statistical Evaluation

5‐Chlor‐2‐methyl‐2,3‐dihydroisothiazol‐3‐on und 2‐Methyl‐2,3‐dihydroisothiazol‐3‐on [MAK Value Documentation in German language, 1991]

5‐Chloro‐2‐methyl‐2,3‐dihydroisothiazol‐3‐one and 2‐Methyl‐2,3‐dihydroisothiazol‐3‐one [MAK Value Documentation, 1993]

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