Sensitization to recombinant Aspergillus fumigatus allergens in allergic fungal sinusitis

McCann, William; Cromie, Marc; Chandler, Francis W.; Ford, Jan; Dolen, William K.

doi:10.1016/s1081-1206(10)61939-4

Cited by 11 publications

(8 citation statements)

References 15 publications

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“…On histopathological analysis, aspergillus was found in 59.57 per cent of our cases; this is similar to McCann and colleagues' and Panda and colleagues' findings 17 , 18 . However, this percentage is much higher than most findings from the western world 19 , 20 .…”

Section: Discussionsupporting

confidence: 89%

Allergic fungal rhinosinusitis with skull base and orbital erosion

et al. 2009

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Allergic fungal rhinosinusitis is a disease of young, immunocompetent individual. Skull base and orbital erosion are seen in one-third of cases. Bone erosion is 6.8 times more common in males than females. Orbital erosion is 1.5 times more common than skull base erosion. Endoscopic surgical debridement and drainage combined with topical steroids leads to resolution of disease in the majority of cases, without resorting to systemic antifungal agents, craniotomy or dural resection.

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Section: Discussionsupporting

confidence: 89%

Allergic fungal rhinosinusitis with skull base and orbital erosion

et al. 2009

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“…27 Some patients with allergic fungal rhinosinusitis do not have an allergic response to fungi identified in their eosinophilic mucin, but may have elevated levels of IgE specific to other fungi. 30 In addition, sera from 18 definitively diagnosed allergic fungal rhinosinusitis patients and six chronic sinusitis patients were tested for IgE specific to A fumigatus and to five recombinant A fumigatus allergens. 29 Ponikau et al concluded that the mere presence of fungi in the nose and sinuses does not indicate pathogenicity, as fungi were present in the nasal cavities of 100 per cent of healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…McCann et al studied allergic mucin from 17 cases of definitively diagnosed allergic fungal rhinosinusitis, using histological analysis to detect fungal elements 30 . In addition, sera from 18 definitively diagnosed allergic fungal rhinosinusitis patients and six chronic sinusitis patients were tested for IgE specific to A fumigatus and to five recombinant A fumigatus allergens.…”

Section: Discussionmentioning

confidence: 99%

Allergic fungal rhinosinusitis: detection of fungal DNA in sinus aspirate using polymerase chain reaction

et al. 2009

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“…Five to ten percent of patients with chronic rhinosinusitis are estimated to be suffering with AFS [66][67][68]. Sensitisation to recombinant Af allergens has demonstrated Af to be an important causative mould for AFS [69].…”

Section: Allergic Aspergillus Sinusitismentioning

confidence: 99%

Allergic Bronchopulmonary Aspergillosis, Allergic Aspergillus Sinusitis and their Co-occurrence

Diwakar¹,

Panjabi²,

Shah³

2008

TOALLJ

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Allergic bronchopulmonary aspergillosis (ABPA), which requires a set of criteria for diagnosis, occurs in atopic individuals, predominantly asthmatics. Oral corticosteroids are the cornerstone for the management of the disease. Allergic Aspergillus sinusitis (AAS), clinico-pathologically similar to ABPA, is also diagnosed with a set of criteria including demonstration of fungal elements in sinus material. Heterogeneous densities on computed tomography of the para-nasal sinuses are caused by the 'allergic mucin' in the sinuses. A combination of oral corticosteroids and surgical removal of impacted sinus mucin is the current approach to treatment. Despite common clinico-immunopathological characteristics, the co-occurrence of both these diseases is a rarely reported phenomenon. This could be due to the fact that the two diseases are often encountered by different specialities. Screening all asthmatics for Aspergillus sensitisation could identify those with severe disease and those at risk for developing ABPA. AAS must be excluded in all patients with ABPA and vice-versa.

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Sensitization to recombinant Aspergillus fumigatus allergens in allergic fungal sinusitis

Cited by 11 publications

References 15 publications

Allergic fungal rhinosinusitis with skull base and orbital erosion

Allergic fungal rhinosinusitis with skull base and orbital erosion

Allergic fungal rhinosinusitis: detection of fungal DNA in sinus aspirate using polymerase chain reaction

Allergic Bronchopulmonary Aspergillosis, Allergic Aspergillus Sinusitis and their Co-occurrence

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