2020
DOI: 10.3390/s20051317
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Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer

Abstract: Cancer represents one of the conditions with the most causes of death worldwide. Common methods for its diagnosis are based on tissue biopsies—the extraction of tissue from the primary tumor, which is used for its histological analysis. However, this technique represents a risk for the patient, along with being expensive and time-consuming and so it cannot be frequently used to follow the progress of the disease. Liquid biopsy is a new cancer diagnostic alternative, which allows the analysis of the molecular i… Show more

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Cited by 43 publications
(34 citation statements)
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References 124 publications
(163 reference statements)
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“…The integration of label‐free imaging, AI, and microfluidics is a subject of great interest in the scientific community to solve open biomedical questions 21,28‐31 . In particular, the authors of the present review strongly believe that such integration would represent a keystone for the identification of CTCs (Figure 1).…”
Section: Introductionmentioning
confidence: 87%
See 1 more Smart Citation
“…The integration of label‐free imaging, AI, and microfluidics is a subject of great interest in the scientific community to solve open biomedical questions 21,28‐31 . In particular, the authors of the present review strongly believe that such integration would represent a keystone for the identification of CTCs (Figure 1).…”
Section: Introductionmentioning
confidence: 87%
“…Indeed, many valuable papers describe the possibility to classify different cell types by combining QPI with AI in the field of tumor cell identification 16‐20 . In this framework, one of the main developing fields for the CTCs detection and isolation regards microfluidic engineering and its ingenious solutions able to perform both in marker‐based and label‐free systems 21‐27 …”
Section: Introductionmentioning
confidence: 99%
“…Ever since their discovery, the detection of circulating tumor cells (CTCs) within liquid biopsies has attracted significant interest as a tool for early cancer diagnosis, metastatic cancer stage and cancer progression monitoring, and therapy response [ 92 , 93 ]. Microfluidic devices for CTCs analyses focus on cell isolation, detection, and examination, demonstrating a high efficiency, selectivity, and reactivity with reduced sample and reagent amounts and increased fluid control [ 71 , 92 ]. Most studies on the matter focus on isolating CTCs through immunoaffinity, which involves the immobilization of specific antibodies on the surface of the microchannels.…”
Section: Diagnostic Applicationsmentioning
confidence: 99%
“…Electrochemical techniques such as cyclic voltammetry (CV), chronoamperometry (CA), differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), and square wave voltammetry (SWV) offer an easy-to-use, affordable, highly sensitive, and reliable way for the ultrasensitive sensing of biomarkers related to such diseases [ 51 , 52 ]. Lab-on-chip biosensors presenting the compact and low-power portable miniaturized devices can be utilized in cancer biomarker discovery research, leading to potential clinical applications [ 53 , 54 , 55 , 56 , 57 ]. The surface architecture connecting the sensing element to the biological sample at the nanometer scale determines signal transduction and the general performance of electrochemical sensors.…”
Section: Nanomaterials/nanoparticles-based Electrochemical Biosensmentioning
confidence: 99%